AiPD: Autoinhibited Protein Database

Q14141

Gene name	SEPTIN6
Protein name	Septin-6
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23157
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

278-434 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

278-434 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q14141

Entry ID	Method	Resolution	Chain	Position	Source
2QAG	X-ray	400 A	B	1-427	PDB
6UPA	X-ray	251 A	B	40-305	PDB
6WBP	X-ray	180 A	A/B	347-399	PDB
7M6J	EM	360 A	B/E	1-427	PDB
AF-Q14141-F1	Predicted				AlphaFoldDB

197 variants for Q14141

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1402602377 CA414379663	3	A>E		No	ClinGen TOPMed
CA334987352 rs1002298615	3	A>T		No	ClinGen gnomAD
rs766039880 CA10502901	4	T>S		No	ClinGen ExAC gnomAD
rs904048399 CA334987351	5	D>N		No	ClinGen Ensembl
CA414379571 rs1411242759	7	A>V		No	ClinGen gnomAD
CA414379555 rs1190093398	8	R>L		No	ClinGen gnomAD
CA10502888 rs756379839	15	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	18	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10502887 COSM3694301 rs142751892	18	P>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA334986014 rs909434497	19	L>V		No	ClinGen TOPMed gnomAD
CA414376339 rs1422509886	20	A>D		No	ClinGen TOPMed
rs779384782 CA10502886	21	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA414376288 rs1350992982	22	H>Q		No	ClinGen TOPMed
CA414376213 rs1459840006	25	F>S		No	ClinGen TOPMed
CA334986012 rs1049334815	27	S>I		No	ClinGen Ensembl
TCGA novel	28	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754207172 CA10502884	29	P>S		No	ClinGen ExAC gnomAD
rs866321109 CA334986011	31	Q>R		No	ClinGen Ensembl
rs750121461 CA10502881	37	V>I		No	ClinGen ExAC TOPMed gnomAD
CA414375879 rs1345809309	38	S>G		No	ClinGen gnomAD
TCGA novel	40	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10502880 rs767080051	45	I>M		No	ClinGen ExAC gnomAD
CA334986010 rs904129054	45	I>V		No	ClinGen TOPMed gnomAD
CA10502878 rs751182700	48	V>M		No	ClinGen ExAC gnomAD
TCGA novel	50	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1270005006 CA414386629	52	G>D		No	ClinGen gnomAD
CA414386580 rs1328230951	56	S>C		No	ClinGen gnomAD
CA414386552 rs1277498379	59	M>L		No	ClinGen gnomAD
rs1277498379 CA414386553	59	M>V		No	ClinGen gnomAD
CA414386525 rs749788809	63	F>I		No	ClinGen ExAC TOPMed gnomAD
CA10502866 rs749788809	63	F>L		No	ClinGen ExAC TOPMed gnomAD
rs780415210 CA10502865	64	N>D		No	ClinGen ExAC gnomAD
CA414386501 rs1391918744	64	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10502864 rs756449713	66	K>R		No	ClinGen ExAC gnomAD
rs745448518 CA10502863	67	F>L		No	ClinGen ExAC gnomAD
rs780988234 CA10502862	68	E>K		No	ClinGen ExAC gnomAD
CA414386421 rs1321809903	70	E>D		No	ClinGen gnomAD
rs1043794760 CA334985024	70	E>K		No	ClinGen TOPMed
CA414386417 rs1457118853	71	P>T		No	ClinGen gnomAD
CA10502861 rs757029176	73	T>A		No	ClinGen ExAC gnomAD
CA414386384 rs1231224061 COSM247254	73	T>I	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed
CA334985023 rs11547934	74	H>N		No	ClinGen Ensembl
rs200008901 CA10502860	75	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs763555927 CA10502859	75	T>R		No	ClinGen ExAC gnomAD
rs199562714 CA334985022	76	Q>H		No	ClinGen TOPMed gnomAD
CA10502858 rs758319667	77	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs186506770 CA334985021	78	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186506770 CA10502856	78	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1256571248 CA414386276	81	L>F		No	ClinGen TOPMed
rs1209292665 CA414386238	83	S>F		No	ClinGen gnomAD
CA10502854 rs200932703	85	T>N		No	ClinGen 1000Genomes ExAC gnomAD
CA10502853 rs776465187	86	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA334985020 rs960522238	86	Y>D		No	ClinGen TOPMed gnomAD
CA10502852 rs767701064	87	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1000835123 CA334985019	91	S>C		No	ClinGen gnomAD
CA414386091 rs1243232786	91	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10502851 rs780764092	94	R>K		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	95	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774447993 COSM1113915 CA10502850	98	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs774447993 CA414385884	98	T>R		No	ClinGen ExAC TOPMed gnomAD
rs138699101 CA10502847	100	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1168033728 CA414385706	105	F>L		No	ClinGen TOPMed
CA414385547 rs1161911413	110	N>K		No	ClinGen gnomAD
rs1390890346 CA414385462	113	D>E		No	ClinGen gnomAD
rs1188049166 CA414385452	114	S>G		No	ClinGen gnomAD
rs1252152227 CA414381747	114	S>R		No	ClinGen TOPMed
rs746618579 CA10502824	119	V>M		No	ClinGen ExAC gnomAD
CA334984135 rs901530290 COSM1625445	121	F>L	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
CA10502823 rs777283174	122	I>V		No	ClinGen ExAC
TCGA novel	124	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747586423 CA10502821	124	A>V		No	ClinGen ExAC gnomAD
CA414381521 rs1440215664	125	Q>R		No	ClinGen gnomAD
rs778522708 CA10502820	129	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA414381239 rs1413945075	137	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA414381215 rs1569430827	138	R>K		No	ClinGen Ensembl
CA414381139 rs1193237119	141	H>Q		No	ClinGen TOPMed
CA334984134 rs371036175	141	H>R		No	ClinGen ESP TOPMed gnomAD
rs1442422868 CA414381113	143	Y>H		No	ClinGen TOPMed
TCGA novel	145	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1603340443 CA414380815	156	A>S		No	ClinGen Ensembl
rs979262494 CA334984131	157	P>L		No	ClinGen TOPMed
rs145877420 CA10502815	158	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs755906559 CA10502816	158	T>S		No	ClinGen ExAC gnomAD
rs1210259480 CA414380652	164	S>Y		No	ClinGen gnomAD
CA414380634 rs1261883616	165	L>P		No	ClinGen TOPMed gnomAD
CA334984130 rs888730781	167	L>P		No	ClinGen Ensembl
CA414380573 rs1230704814	168	V>A		No	ClinGen gnomAD
rs765441452 CA10502811	169	T>I		No	ClinGen ExAC gnomAD
CA414378960 rs1380697070	183	I>V		No	ClinGen gnomAD
TCGA novel	187	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866977085 COSM1225244 CA16040518	190	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
TCGA novel	191	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414378642 rs1389342206	199	I>T		No	ClinGen gnomAD
CA10502793 rs755116599	206	V>F		No	ClinGen ExAC TOPMed gnomAD
CA414378489 rs1443580117	207	S>N		No	ClinGen gnomAD
rs1330524808 CA414378453	209	G>R		No	ClinGen TOPMed
CA10502790 rs761281823	212	I>T		No	ClinGen ExAC gnomAD
CA334983924 rs137927954	218	D>N		No	ClinGen ESP TOPMed gnomAD
CA10502789 rs758895519	221	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs768363612 CA10502785	229	M>V		No	ClinGen ExAC TOPMed gnomAD
rs748783813 CA10502784	230	N>S		No	ClinGen ExAC TOPMed gnomAD
CA414377286 rs1242552845	232	H>R		No	ClinGen gnomAD
CA10502747 rs752361865	232	H>Y		No	ClinGen ExAC gnomAD
rs764588243 CA10502746	234	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA414377185 rs1269914406	240	S>R		No	ClinGen gnomAD
TCGA novel	243	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10502744 rs776067307	246	I>T		No	ClinGen ExAC gnomAD
rs770865725 CA10502743	250	M>I		No	ClinGen ExAC TOPMed gnomAD
rs973965192 CA334983232	253	A>T		No	ClinGen Ensembl
CA414376927 rs1277481730	253	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	254	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	257	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414376832 rs1437439596	257	P>L		No	ClinGen TOPMed
TCGA novel	257	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10502741 rs371143998	257	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA414376782 rs1313683898	259	G>D		No	ClinGen gnomAD
TCGA novel	263	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1449007499 CA414376716	263	V>I		No	ClinGen TOPMed
TCGA novel	266	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10502723 rs773285576	270	D>N		No	ClinGen ExAC gnomAD
CA414375076 rs1314271263	271	F>S		No	ClinGen TOPMed
CA414374997 rs149227275	275	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs149227275 CA10502722	275	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs746541392 CA334982971	275	R>W		No	ClinGen TOPMed
CA10502721 rs4335271	280	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10502720 rs774062800	280	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA334982970 COSM1465229 rs4335271	280	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs770027309 CA10502719	283	M>V		No	ClinGen ExAC gnomAD
CA414374861 rs1420235417	285	D>N		No	ClinGen gnomAD
CA10502718 rs746109010	287	R>Q		No	ClinGen ExAC gnomAD
CA414374840 rs1250800962	287	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10502715 rs747452514	293	R>L		No	ClinGen ExAC TOPMed gnomAD
rs747452514 CA10502716	293	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs781286262 CA10502717	293	R>W		No	ClinGen ExAC TOPMed gnomAD
CA414374788 rs1200794980	294	H>Y		No	ClinGen gnomAD
rs1327604408 CA414374770	295	Y>C		No	ClinGen gnomAD
CA10502714 rs778251936	299	R>C		No	ClinGen ExAC gnomAD
COSM3424396 CA10502712 rs202165661	300	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1004926823 CA334982966	300	R>H		No	ClinGen TOPMed
rs1355032750 CA414374627	306	M>V		No	ClinGen TOPMed
rs1214535940 CA414374568	310	D>N		No	ClinGen gnomAD
CA10502708 rs765918846	312	D>N		No	ClinGen ExAC gnomAD
TCGA novel	329	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382009114 CA414373837	331	F>V		No	ClinGen gnomAD
TCGA novel	336	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	339	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	342	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA334982720 rs200952589	343	R>K		No	ClinGen Ensembl
rs1178428302 CA414373736	344	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10502672 rs760931761	345	M>I		No	ClinGen ExAC gnomAD
rs766570333 CA10502673	345	M>L		No	ClinGen ExAC TOPMed gnomAD
rs766570333 CA414373734	345	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	347	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1398546784 CA414373720	347	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA10502670 rs748619436	349	R>*		No	ClinGen ExAC gnomAD
rs943889211 CA334982719	349	R>Q		No	ClinGen TOPMed
CA10502668 rs201323262	350	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA414373696 rs1178226799	351	K>Q		No	ClinGen TOPMed
rs769262072 CA10502667	352	E>K		No	ClinGen ExAC gnomAD
rs780604408 CA10502665	355	A>V		No	ClinGen ExAC gnomAD
TCGA novel	356	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10502663 rs745539594	356	E>D		No	ClinGen ExAC gnomAD
rs1323775115 CA414373631	360	A>T		No	ClinGen gnomAD
TCGA novel	362	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756729336 CA10502660	362	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	363	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261601310 CA414373282	366	E>D		No	ClinGen gnomAD
CA10502652 rs767841172	366	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1185195184 CA414373273	367	K>N		No	ClinGen gnomAD
CA10502651 rs150468538 COSM3694300	370	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs774531425 CA10502650	370	R>H		No	ClinGen ExAC TOPMed gnomAD
CA10502649 rs769023146	374	L>V		No	ClinGen ExAC gnomAD
CA414373146 rs1436628958	385	K>T		No	ClinGen gnomAD
CA10502646 rs770285776	387	K>T		No	ClinGen ExAC
rs917081681 CA334982422	390	D>N		No	ClinGen TOPMed
CA10502645 rs745458590	393	V>M		No	ClinGen ExAC gnomAD
rs187932850 CA10502644	394	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA414373047 rs1347083285	399	R>I		No	ClinGen TOPMed gnomAD
rs1347083285 CA414373049	399	R>K		No	ClinGen TOPMed gnomAD
CA414373045 rs1303393531	399	R>S		No	ClinGen TOPMed gnomAD
rs770681536 CA10502643 COSM1294484	401	T>M	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10502642 rs746468087	402	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	403	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	403	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA334982420 rs17856302	406	L>P		No	ClinGen Ensembl
CA10502639 rs752639688	407	Q>H		No	ClinGen ExAC gnomAD
CA10502638 rs778625882	408	S>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	410	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773281135 CA10502637	411	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1252894114 CA414372965	412	Q>H		No	ClinGen gnomAD
rs1340574657 CA414372958	413	A>V		No	ClinGen TOPMed
CA414372910 rs1045609413	421	R>K		No	ClinGen gnomAD
CA334982417 rs1045609413	421	R>T		No	ClinGen gnomAD
TCGA novel	424	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs918690913 CA334982416	424	E>D		No	ClinGen TOPMed
TCGA novel	427	N>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768533782 CA10502597	433	T>S		No	ClinGen ExAC gnomAD

No associated diseases with Q14141

1 regional properties for Q14141

Type	Name	Position	InterPro Accession
domain	Septin-type guanine nucleotide-binding (G) domain	39 - 308	IPR030379

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cleavage furrow Midbody Cell projection, cilium, flagellum	In metaphase cells, localized within the microtubule spindle At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle Found in the sperm annulus (PubMed:25588830)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
axon terminus	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cell division site	The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cleavage furrow	The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
septin collar	A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.
septin complex	A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
septin ring	A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.
sperm annulus	The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

3 GO annotations of molecular function

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

6 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
cytoskeleton-dependent cytokinesis	A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.
mitotic cytokinesis	A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32468	CDC12	Cell division control protein 12	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q07657	SHS1	Seventh homolog of septin 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P32457	CDC3	Cell division control protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
A2VE99	SEPTIN11	Septin-11	Bos taurus (Bovine)	PR
A6QQL3	SEPTIN14	Septin-14	Bos taurus (Bovine)	PR
Q3SZN0	SEPTIN6	Septin-6	Bos taurus (Bovine)	PR
P54359	02-Sep	Septin-2	Drosophila melanogaster (Fruit fly)	PR
Q16181	SEPTIN7	Septin-7	Homo sapiens (Human)	PR
Q9P0V9	SEPTIN10	Septin-10	Homo sapiens (Human)	PR
Q9NVA2	SEPTIN11	Septin-11	Homo sapiens (Human)	PR
Q9UH03	SEPTIN3	Neuronal-specific septin-3	Homo sapiens (Human)	PR
Q9UHD8	SEPTIN9	Septin-9	Homo sapiens (Human)	PR
Q8C1B7	Septin11	Septin-11	Mus musculus (Mouse)	PR
Q8CHH9	Septin8	Septin-8	Mus musculus (Mouse)	PR
Q9DA97	Septin14	Septin-14	Mus musculus (Mouse)	PR
Q9R1T4	Septin6	Septin-6	Mus musculus (Mouse)	PR
B0BNF1	Septin8	Septin-8	Rattus norvegicus (Rat)	PR
B3GNI6	Septin11	Septin-11	Rattus norvegicus (Rat)	PR
A4FUM1	sept8b	Septin-8-B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q642H3	sept8a	Septin-8-A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAATDIARQV	GEGCRTVPLA	GHVGFDSLPD	QLVNKSVSQG	FCFNILCVGE	TGLGKSTLMD
70	80	90	100	110	120
TLFNTKFEGE	PATHTQPGVQ	LQSNTYDLQE	SNVRLKLTIV	STVGFGDQIN	KEDSYKPIVE
130	140	150	160	170	180
FIDAQFEAYL	QEELKIRRVL	HTYHDSRIHV	CLYFIAPTGH	SLKSLDLVTM	KKLDSKVNII
190	200	210	220	230	240
PIIAKADAIS	KSELTKFKIK	ITSELVSNGV	QIYQFPTDDE	SVAEINGTMN	AHLPFAVIGS
250	260	270	280	290	300
TEELKIGNKM	MRARQYPWGT	VQVENEAHCD	FVKLREMLIR	VNMEDLREQT	HTRHYELYRR
310	320	330	340	350	360
CKLEEMGFKD	TDPDSKPFSL	QETYEAKRNE	FLGELQKKEE	EMRQMFVQRV	KEKEAELKEA
370	380	390	400	410	420
EKELHEKFDR	LKKLHQDEKK	KLEDKKKSLD	DEVNAFKQRK	TAAELLQSQG	SQAGGSQTLK
430
RDKEKKNNPW	LCTE