AiPD: Autoinhibited Protein Database

Q16181

Gene name	SEPTIN7
Protein name	Septin-7
Names	CDC10 protein homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:989
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-119 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for Q16181

Entry ID	Method	Resolution	Chain	Position	Source
2QAG	X-ray	400 A	C	20-437	PDB
3T5D	X-ray	330 A	A/C	48-316	PDB
3TW4	X-ray	335 A	A/B	48-317	PDB
6N0B	X-ray	174 A	A/B/C/D	48-318	PDB
6N12	X-ray	223 A	A/B	48-318	PDB
6UQQ	X-ray	275 A	A/B	48-318	PDB
7M6J	EM	360 A	C/D	20-437	PDB
AF-Q16181-F1	Predicted				AlphaFoldDB

206 variants for Q16181

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs547978971 CA4217959	2	S>L	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367267835 rs1583468090	3	V>A	No	ClinGen Ensembl
rs1282514727 CA367267842	4	S>N	No	ClinGen gnomAD
CA157234201 rs963690545	4	S>R	No	ClinGen TOPMed
CA367267850 rs765776685	4	S>R	No	ClinGen ExAC TOPMed gnomAD
rs1282514727 CA367267844	4	S>T	No	ClinGen gnomAD
CA367267857 rs753275736	5	A>E	No	ClinGen ExAC TOPMed gnomAD
CA4217961 rs753275736	5	A>G	No	ClinGen ExAC TOPMed gnomAD
rs753275736 CA367267860	5	A>V	No	ClinGen ExAC TOPMed gnomAD
CA4217962 rs758649882	6	R>T	No	ClinGen ExAC TOPMed gnomAD
rs369243241 CA4217963	7	S>C	No	ClinGen ESP ExAC TOPMed gnomAD
rs369243241 CA367267879	7	S>F	No	ClinGen ESP ExAC TOPMed gnomAD
rs369243241 CA367267877	7	S>Y	No	ClinGen ESP ExAC TOPMed gnomAD
rs868161118 CA157234211	8	A>T	No	ClinGen Ensembl
CA367267892 rs1469510145	8	A>V	No	ClinGen gnomAD
rs781461598 CA4217967	9	A>P	No	ClinGen ExAC TOPMed gnomAD
CA367267899 rs781461598	9	A>S	No	ClinGen ExAC TOPMed gnomAD
CA157234229 rs867995194	10	A>S	No	ClinGen Ensembl
CA367267914 rs1160144688	10	A>V	No	ClinGen TOPMed gnomAD
rs749282513 CA4217971	11	E>*	No	ClinGen ExAC TOPMed gnomAD
rs868237331 CA157234238	11	E>D	No	ClinGen gnomAD
rs749282513 CA367267918	11	E>K	No	ClinGen ExAC TOPMed gnomAD
rs1468288535 CA367267931	12	E>*	No	ClinGen TOPMed gnomAD
CA367267940 rs1338717519	12	E>G	No	ClinGen gnomAD
rs1468288535 CA367267934	12	E>K	No	ClinGen TOPMed gnomAD
rs1468288535 CA367267932	12	E>Q	No	ClinGen TOPMed gnomAD
CA367267950 rs1442063481	13	R>K	No	ClinGen TOPMed gnomAD
CA367267952 rs1442063481	13	R>T	No	ClinGen TOPMed gnomAD
rs1341599571 CA367267948	13	R>W	No	ClinGen gnomAD
CA157234239 rs910715459	14	S>G	No	ClinGen TOPMed gnomAD
CA367267969 rs768520445	14	S>I	No	ClinGen ExAC TOPMed gnomAD
rs768520445 CA4217972	14	S>N	No	ClinGen ExAC TOPMed gnomAD
rs768520445 CA367267967	14	S>T	No	ClinGen ExAC TOPMed gnomAD
CA367267975 rs1262113491	15	V>I	No	ClinGen gnomAD
CA367267990 rs1205029524	16	N>D	No	ClinGen TOPMed gnomAD
rs1437193939 CA367268001	16	N>K	No	ClinGen gnomAD
CA4217973 rs774176679	16	N>S	No	ClinGen ExAC gnomAD
CA4217974 rs761574423	17	S>C	No	ClinGen ExAC gnomAD
CA367268036 rs1470389733	18	S>R	No	ClinGen TOPMed gnomAD
CA367268044 rs1218286205	19	T>S	No	ClinGen TOPMed
rs1382742310 CA574066298	23	Q>LF*	No	ClinGen gnomAD
CA367269690 rs1446405480	24	Q>K	No	ClinGen gnomAD
rs1286379276 CA367269712	25	K>N	No	ClinGen gnomAD
rs1562532566 CA367269717	26	N>D	No	ClinGen Ensembl
rs571691250 CA4218052	27	L>F	No	ClinGen 1000Genomes ExAC gnomAD
CA367269751 rs1222918980	28	E>G	No	ClinGen gnomAD
rs1286058297 CA367269780	30	Y>C	No	ClinGen gnomAD
rs1286058297 CA367269779	30	Y>S	No	ClinGen gnomAD
rs781017831 CA4218053	35	N>S	No	ClinGen ExAC TOPMed gnomAD
rs1255653313 CA367269907	41	Y>H	No	ClinGen TOPMed gnomAD
CA157251151 rs368828270	43	K>N	No	ClinGen ESP
CA4218055 rs780819505	44	S>L	No	ClinGen ExAC gnomAD
CA367270035 rs1199221090	51	F>L	No	ClinGen gnomAD
CA4218059 rs375889436	52	T>M	No	ClinGen ESP ExAC gnomAD
CA4218062 rs773665336	53	L>I	No	ClinGen ExAC
CA4218063 rs747481524	54	M>T	No	ClinGen ExAC gnomAD
CA367270055 rs1473673889	55	V>I	No	ClinGen gnomAD
CA367268367 rs1192771815	59	S>A	No	ClinGen TOPMed
CA367268365 rs1192771815	59	S>T	No	ClinGen TOPMed
rs1463663878 CA367268403	64	S>L	No	ClinGen TOPMed
rs11538079 CA157263524	71	F>L	No	ClinGen Ensembl
CA4218081 rs771335352	71	F>S	No	ClinGen ExAC gnomAD
rs781724703 CA4218082	74	D>N	No	ClinGen ExAC gnomAD
rs770217624 CA4218084	77	S>F	No	ClinGen ExAC gnomAD
rs199739906 CA4218085	78	P>S	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1277088816 CA367268513	81	P>A	No	ClinGen TOPMed
rs1274885676 CA367268518	82	G>R	No	ClinGen gnomAD
CA157263543 rs781188337	91	V>L	No	ClinGen Ensembl
rs1562558306 CA367268588	92	Q>R	No	ClinGen Ensembl
rs1450561631 CA367268629	96	S>A	No	ClinGen gnomAD
CA4218106 rs749730840	97	K>R	No	ClinGen ExAC gnomAD
rs1367066878 CA367268647	99	L>V	No	ClinGen gnomAD
CA367268657 rs1194061662	100	I>T	No	ClinGen TOPMed gnomAD
CA367268686 rs1459162293	104	G>V	No	ClinGen gnomAD
CA4218108 rs774639891	105	V>G	No	ClinGen ExAC gnomAD
rs768999171 CA4218107	105	V>I	No	ClinGen ExAC gnomAD
rs1375285739 CA367268693	106	Q>E	No	ClinGen gnomAD
CA157267697 rs574634510 CA367268705	107	L>F	No	ClinGen gnomAD
rs1172338843 CA367268718	110	T>A	No	ClinGen TOPMed gnomAD
rs1389328836 CA367268723	111	I>V	No	ClinGen gnomAD
CA367268730 rs1451763008	112	V>I	No	ClinGen gnomAD
CA4218109 rs761746094	114	T>N	No	ClinGen ExAC gnomAD
rs1288193560 CA367268765	117	F>S	No	ClinGen TOPMed
rs1211962114 CA367268778	119	D>G	No	ClinGen TOPMed
CA367268848 rs1428910812	127	W>G	No	ClinGen TOPMed
CA367268882 rs765111999	131	I>M	No	ClinGen ExAC gnomAD
rs775189882 CA4218136	132	D>N	No	ClinGen ExAC gnomAD
CA367268895 rs1466447754	133	Y>C	No	ClinGen gnomAD
rs11538081 CA157268057	134	I>V	No	ClinGen Ensembl
rs762644796 CA4218137	136	S>G	No	ClinGen ExAC gnomAD
rs1368442987 CA367268948	140	D>V	No	ClinGen TOPMed
CA367268993 rs1583600284	147	R>*	No	ClinGen Ensembl
CA157268060 rs970771673	151	R>C	No	ClinGen TOPMed gnomAD
rs763712762 CA4218138	154	P>S	No	ClinGen ExAC gnomAD
rs751077685 CA4218139	156	N>S	No	ClinGen ExAC TOPMed gnomAD
CA4218142 rs754422485	160	C>F	No	ClinGen ExAC gnomAD
rs755357863 CA4218143	162	L>F	No	ClinGen ExAC TOPMed gnomAD
CA4218144 rs779310600	164	F>S	No	ClinGen ExAC gnomAD
CA367269152 rs1206919540	170	H>R	No	ClinGen TOPMed gnomAD
rs1236697143 CA367269150	170	H>Y	No	ClinGen gnomAD
CA367269156 rs1258876781	171	G>R	No	ClinGen TOPMed
rs1450344508 CA367269529	174	P>S	No	ClinGen gnomAD
rs1189003360 CA367269549	177	I>V	No	ClinGen gnomAD
rs1162938980 CA367269570	179	F>L	No	ClinGen gnomAD
CA367269574 rs1351743631	180	M>V	No	ClinGen gnomAD
rs765728361 CA4218163	181	K>N	No	ClinGen ExAC TOPMed gnomAD
CA367269607 rs1319888049	182	R>C	No	ClinGen gnomAD
rs745712983 CA4218164	182	R>H	No	ClinGen ExAC TOPMed gnomAD
CA4218166 rs778001627	185	E>G	No	ClinGen ExAC gnomAD
rs751809485 CA4218167	188	N>S	No	ClinGen ExAC TOPMed gnomAD
CA367269691 rs1182225778	190	I>L	No	ClinGen TOPMed
rs757510137 CA4218168	190	I>T	No	ClinGen ExAC gnomAD
rs746005567 CA4218170	199	L>F	No	ClinGen ExAC TOPMed gnomAD
CA367269831 rs1265645647	200	T>I	No	ClinGen gnomAD
rs769767796 CA4218171	201	P>S	No	ClinGen ExAC gnomAD
rs779862600 CA4218172	202	E>D	No	ClinGen ExAC TOPMed gnomAD
rs1379271783 CA367269911	205	Q>K	No	ClinGen gnomAD
CA4218173 rs749056864	206	Q>H	No	ClinGen ExAC TOPMed gnomAD
rs1294581509 CA367270118	215	I>T	No	ClinGen TOPMed
CA367270141 rs1470272403	218	H>R	No	ClinGen gnomAD
CA367270157 rs1177134218	220	I>T	No	ClinGen gnomAD
CA157273092 rs543252898	222	I>M	No	ClinGen gnomAD
rs1396052968 CA367270175	223	Y>H	No	ClinGen TOPMed
CA367270185 rs1376415583	224	E>A	No	ClinGen gnomAD
rs1178756333 CA367270184	224	E>K	No	ClinGen gnomAD
CA4218188 rs781461599	228	T>A	No	ClinGen ExAC gnomAD
rs1444134255 CA367270257	233	E>G	No	ClinGen TOPMed
rs1400727688 CA367270278	236	L>V	No	ClinGen TOPMed
CA367270301 rs1325525493	239	K>R	No	ClinGen TOPMed
CA367270346 rs1583620560	242	D>E	No	ClinGen Ensembl
CA4218204 rs370969117	243	R>C	No	ClinGen ESP ExAC TOPMed gnomAD
rs1289333452 CA367270349	243	R>H	No	ClinGen TOPMed gnomAD
rs767670433 CA4218205	249	V>I	No	ClinGen ExAC TOPMed gnomAD
CA4218208 rs756181603	254	I>L	No	ClinGen ExAC TOPMed gnomAD
rs754002735 CA4218209	254	I>T	No	ClinGen ExAC gnomAD
CA4218207 rs756181603	254	I>V	No	ClinGen ExAC TOPMed gnomAD
rs754863481 CA4218210	260	K>R	No	ClinGen ExAC TOPMed gnomAD
rs1583620677 CA367270469	261	R>S	No	ClinGen Ensembl
rs778995475 CA4218211	266	Q>H	No	ClinGen ExAC gnomAD
CA367270502 rs1199377689	266	Q>L	No	ClinGen TOPMed
rs1162277681 CA367270512	268	P>T	No	ClinGen gnomAD
rs1388020783 CA367270538	271	V>A	No	ClinGen gnomAD
CA367270640 rs1254483007	284	I>V	No	ClinGen TOPMed gnomAD
rs1188218903 CA367270662	287	N>S	No	ClinGen gnomAD
CA4218238 rs769341158	288	M>T	No	ClinGen ExAC gnomAD
CA367270715 rs1468892434	293	H>N	No	ClinGen gnomAD
rs747316599 CA4218271	298	K>E	No	ClinGen ExAC TOPMed gnomAD
CA367270763 rs1246028482	299	D>Y	No	ClinGen gnomAD
rs1486734843 CA367270781	301	T>I	No	ClinGen gnomAD
rs771370308 CA4218272	302	N>D	No	ClinGen ExAC gnomAD
CA4218273 rs776892910	303	N>S	No	ClinGen ExAC
rs375490583 CA4218274	304	V>I	No	ClinGen ESP ExAC TOPMed gnomAD
rs1420068114 CA367270814	306	Y>C	No	ClinGen gnomAD
rs1340487378 CA367270810	306	Y>H	No	ClinGen TOPMed
rs1234497394 CA367270832	308	N>K	No	ClinGen gnomAD
CA367270829 rs1444429110	308	N>S	No	ClinGen TOPMed
rs1583635101 CA367270856	312	R>G	No	ClinGen Ensembl
CA157278701 rs988669499	315	A>V	No	ClinGen TOPMed
CA367270901 rs1433328982	319	Y>H	No	ClinGen gnomAD
CA4218277 rs763191546	320	N>S	No	ClinGen ExAC gnomAD
CA367270919 rs1412505847	321	G>A	No	ClinGen gnomAD
rs1562582943 CA367270921	322	V>I	No	ClinGen Ensembl
rs1411886354 CA367270931	323	D>G	No	ClinGen TOPMed
CA367270949 rs1294665752	325	N>K	No	ClinGen gnomAD
CA157278715 rs13239533	325	N>T	No	ClinGen Ensembl
rs1487143530 CA367270966	328	K>Q	No	ClinGen gnomAD
rs981304633 CA157278729	330	Q>R	No	ClinGen TOPMed
CA367271296 rs1294218320	335	P>S	No	ClinGen TOPMed
CA367271344 rs1282744124	342	E>Q	No	ClinGen gnomAD
CA367271364 rs1181579572	344	R>S	No	ClinGen gnomAD
rs1562590029 CA367271432	353	M>T	No	ClinGen Ensembl
rs1178267980 CA367271486	359	Q>H	No	ClinGen gnomAD
rs1300346939 CA367271533	366	K>E	No	ClinGen TOPMed
rs1583650370 CA367271566	370	Q>R	No	ClinGen Ensembl
rs1326379004 CA367271664	381	R>Q	No	ClinGen gnomAD
CA367271660 rs1244347828	381	R>W	No	ClinGen TOPMed
rs761757988 CA4218302	382	R>C	No	ClinGen ExAC gnomAD
CA367271667 rs1268643235	382	R>H	No	ClinGen TOPMed gnomAD
rs1341690255 CA367271693	385	Q>H	No	ClinGen gnomAD
CA367271703 rs1416446156	387	K>E	No	ClinGen TOPMed
rs1375942774 CA367271707	387	K>R	No	ClinGen TOPMed
rs1215266377 CA367271715	388	K>R	No	ClinGen gnomAD
CA367271746 rs1307377344	392	A>V	No	ClinGen TOPMed
rs1446796189 CA367271813	401	R>C	No	ClinGen TOPMed gnomAD
CA4218304 rs772920680	401	R>H	No	ClinGen ExAC TOPMed gnomAD
rs375555966 CA4218305	402	R>C	No	ClinGen ESP ExAC TOPMed gnomAD
CA4218306 rs765997248	402	R>H	No	ClinGen ExAC TOPMed gnomAD
rs375555966 CA367271816	402	R>S	No	ClinGen ESP ExAC TOPMed gnomAD
rs1162180006 CA367271824	403	Q>R	No	ClinGen gnomAD
rs1414980517 CA367271833	404	F>C	No	ClinGen gnomAD
rs1165581420 CA367271836	405	E>K	No	ClinGen gnomAD
rs754620356 CA4218308	408	K>N	No	ClinGen ExAC gnomAD
rs1319988003 CA367271871	409	A>G	No	ClinGen gnomAD
CA4218311 rs752162655	415	Q>E	No	ClinGen ExAC TOPMed gnomAD
CA367271921 rs1292825433	416	R>C	No	ClinGen gnomAD
rs1332746119 CA367271922	416	R>H	No	ClinGen gnomAD
CA367271929 rs1274355923	417	I>T	No	ClinGen gnomAD
CA367271925 rs1235146842	417	I>V	No	ClinGen TOPMed gnomAD
CA367271971 rs1286754370	423	S>T	No	ClinGen gnomAD
rs746221445 CA4218315	424	S>L	No	ClinGen ExAC gnomAD
CA367272042 rs760435092	431	K>M	No	ClinGen ExAC gnomAD
rs760435092 CA4218324	431	K>R	No	ClinGen ExAC gnomAD
rs766125911 CA157285061	432	K>N	No	ClinGen ExAC gnomAD
rs776436237 CA4218326	434	G>E	No	ClinGen ExAC
rs1213314201 CA367272074	436	I>L	No	ClinGen TOPMed
CA367272080 rs1211043739	436	I>M	No	ClinGen gnomAD

No associated diseases with Q16181

1 regional properties for Q16181

Type	Name	Position	InterPro Accession
domain	Septin-type guanine nucleotide-binding (G) domain	47 - 318	IPR030379

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Cleavage furrow Midbody Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum	Distributed throughout the cytoplasm in prometaphase cells Associated with the spindle during metaphase Associated with the central spindle and at the cleavage furrow in anaphase cells Detected at the midbody in telophase Associated with actin stress fibers (By similarity) Found in the sperm annulus (PubMed:25588830)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
cell division site	The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cleavage furrow	The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
non-motile cilium	A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
septin complex	A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
septin ring	A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.
sperm annulus	The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
stress fiber	A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

6 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
identical protein binding	Binding to an identical protein or proteins.
molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

7 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
cytoskeleton-dependent cytokinesis	A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.
positive regulation of non-motile cilium assembly	Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.
regulation of embryonic cell shape	Any process that modulates the surface configuration of an embryonic cell.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32468	CDC12	Cell division control protein 12	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q07657	SHS1	Seventh homolog of septin 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P32457	CDC3	Cell division control protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q6Q137	SEPTIN7	Septin-7	Bos taurus (Bovine)	PR
Q5R1W1	SEPTIN7	Septin-7	Pan troglodytes (Chimpanzee)	PR
Q14141	SEPTIN6	Septin-6	Homo sapiens (Human)	PR
Q9P0V9	SEPTIN10	Septin-10	Homo sapiens (Human)	PR
Q9NVA2	SEPTIN11	Septin-11	Homo sapiens (Human)	PR
Q9UH03	SEPTIN3	Neuronal-specific septin-3	Homo sapiens (Human)	PR
Q9UHD8	SEPTIN9	Septin-9	Homo sapiens (Human)	PR
P28661	Septin4	Septin-4	Mus musculus (Mouse)	PR
O55131	Septin7	Septin-7	Mus musculus (Mouse)	PR
Q9WVC0	Septin7	Septin-7	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSVSARSAAA	EERSVNSSTM	VAQQKNLEGY	VGFANLPNQV	YRKSVKRGFE	FTLMVVGESG
70	80	90	100	110	120
LGKSTLINSL	FLTDLYSPEY	PGPSHRIKKT	VQVEQSKVLI	KEGGVQLLLT	IVDTPGFGDA
130	140	150	160	170	180
VDNSNCWQPV	IDYIDSKFED	YLNAESRVNR	RQMPDNRVQC	CLYFIAPSGH	GLKPLDIEFM
190	200	210	220	230	240
KRLHEKVNII	PLIAKADTLT	PEECQQFKKQ	IMKEIQEHKI	KIYEFPETDD	EEENKLVKKI
250	260	270	280	290	300
KDRLPLAVVG	SNTIIEVNGK	RVRGRQYPWG	VAEVENGEHC	DFTILRNMLI	RTHMQDLKDV
310	320	330	340	350	360
TNNVHYENYR	SRKLAAVTYN	GVDNNKNKGQ	LTKSPLAQME	EERREHVAKM	KKMEMEMEQV
370	380	390	400	410	420
FEMKVKEKVQ	KLKDSEAELQ	RRHEQMKKNL	EAQHKELEEK	RRQFEDEKAN	WEAQQRILEQ
430
QNSSRTLEKN	KKKGKIF