Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

2 structures for Q9NVA2

Entry ID Method Resolution Chain Position Source
6UPQ X-ray 186 A B 40-306 PDB
AF-Q9NVA2-F1 Predicted AlphaFoldDB

242 variants for Q9NVA2

Variant ID(s) Position Change Description Diseaes Association Provenance
CA100226641
rs751652079
2 A>P No ClinGen
TOPMed
gnomAD
rs1303114153
CA357453206
3 V>E No ClinGen
TOPMed
gnomAD
CA357453203
rs1387288530
3 V>M No ClinGen
gnomAD
TCGA novel 4 A>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1578107258
CA357453220
5 V>G No ClinGen
Ensembl
rs1329197566
CA357453223
6 G>W No ClinGen
gnomAD
rs755127981
CA2973840
8 P>A No ClinGen
ExAC
TOPMed
gnomAD
CA2973839
rs755127981
8 P>S No ClinGen
ExAC
TOPMed
gnomAD
rs1253832332
CA357452959
15 N>H No ClinGen
gnomAD
CA357452969
rs1578159060
16 L>F No ClinGen
Ensembl
CA2973859
rs763601314
16 L>W No ClinGen
ExAC
gnomAD
rs572347228
CA2973860
17 S>C No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs757240714
CA2973861
21 H>D No ClinGen
ExAC
gnomAD
CA100231253
rs982583201
21 H>L No ClinGen
gnomAD
CA357452998
rs982583201
21 H>R No ClinGen
gnomAD
CA2973862
rs780984694
22 V>G No ClinGen
ExAC
CA100231255
rs77258456
24 F>L No ClinGen
Ensembl
rs1374900833
CA357453028
26 S>G No ClinGen
gnomAD
CA100231256
rs919706619
27 L>V No ClinGen
TOPMed
gnomAD
rs1334450177
CA357453067
32 V>I No ClinGen
gnomAD
rs1359204415
CA357453129
41 C>S No ClinGen
TOPMed
CA357453153
rs1158504115
44 I>L No ClinGen
TOPMed
CA357453167
rs1385299687
46 C>R No ClinGen
TOPMed
rs1464993625
CA357453169
46 C>Y No ClinGen
gnomAD
CA357453179
rs1183288525
47 V>A No ClinGen
TOPMed
CA2973863
rs745711264
48 G>S No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 49 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357453564
rs1271422997
51 G>A No ClinGen
gnomAD
rs1336926547
CA357453567
52 I>V No ClinGen
gnomAD
TCGA novel 53 G>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357453598
rs1369285397
56 T>M No ClinGen
gnomAD
rs1290443274
CA357453608
58 M>V No ClinGen
gnomAD
CA2973880
rs750349530
59 D>G No ClinGen
ExAC
gnomAD
rs539508758
CA100232133
60 T>I No ClinGen
Ensembl
CA357453666
rs1211531842
66 F>L No ClinGen
gnomAD
CA357453664
rs1211531842
66 F>V No ClinGen
gnomAD
CA2973881
rs756037913
68 S>N No ClinGen
ExAC
gnomAD
CA2973883
rs749031947
70 P>A No ClinGen
ExAC
gnomAD
CA100232134
rs906911431
71 A>G No ClinGen
Ensembl
rs1371388312
CA357453701
71 A>P No ClinGen
gnomAD
rs1416508651
CA357453709
72 T>I No ClinGen
TOPMed
gnomAD
rs1163942386
CA357453705
72 T>P No ClinGen
gnomAD
CA2973886
rs747135234
73 H>R No ClinGen
ExAC
gnomAD
CA357453723
rs746370026
74 N>K No ClinGen
ExAC
TOPMed
gnomAD
CA2973887
rs373899046
74 N>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA2973888
rs373899046
74 N>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs770527495
CA100232135
76 P>A No ClinGen
Ensembl
rs770280904
CA2973890
76 P>L No ClinGen
ExAC
gnomAD
CA100232136
rs368053703
77 G>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA2973891
rs368053703
77 G>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA357453740
rs1300009762
78 V>I No ClinGen
gnomAD
rs768334962
CA2973893
79 R>Q No ClinGen
ExAC
TOPMed
gnomAD
rs763296282
CA2973892
79 R>W Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs952242554
CA100232137
83 R>G No ClinGen
TOPMed
gnomAD
CA100232138
rs985469736
83 R>K No ClinGen
TOPMed
CA2973895
rs759200154
84 S>I No ClinGen
ExAC
TOPMed
gnomAD
CA357453796
rs1578172928
86 E>D No ClinGen
Ensembl
CA100232139
rs1015164929
87 L>F No ClinGen
gnomAD
CA357453798
rs1015164929
87 L>I No ClinGen
gnomAD
rs1259870648
CA357453820
90 S>G No ClinGen
TOPMed
gnomAD
rs189107905
CA2973896
91 N>S No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs574096825
CA2973898
93 R>Q No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs749880859
CA2973897
93 R>W No ClinGen
ExAC
TOPMed
gnomAD
rs1487868536
CA357453846
94 L>P No ClinGen
gnomAD
CA357453869
rs1005391417
98 I>L No ClinGen
TOPMed
gnomAD
CA100232140
rs1005391417
98 I>V No ClinGen
TOPMed
gnomAD
rs1164877184
CA357453875
99 V>I No ClinGen
gnomAD
CA357453882
rs1214137441
100 D>H No ClinGen
gnomAD
rs753728133
CA2973900
101 T>A No ClinGen
ExAC
TOPMed
gnomAD
rs754798776
CA2973901
101 T>N No ClinGen
ExAC
TOPMed
gnomAD
rs778803150
CA2973902
102 V>M No ClinGen
ExAC
TOPMed
gnomAD
rs1382235136
CA357453915
105 G>E No ClinGen
gnomAD
CA2973904
rs757437859
107 Q>H No ClinGen
ExAC
gnomAD
CA100232142
rs752613701
108 I>K No ClinGen
Ensembl
CA2973905
rs147132354
108 I>L No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1292551449
CA357453938
109 N>H No ClinGen
gnomAD
TCGA novel 115 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357454010
rs752486817
116 P>L No ClinGen
ExAC
gnomAD
rs752486817
CA2973924
116 P>Q No ClinGen
ExAC
gnomAD
rs767777730
CA2973926
117 I>V No ClinGen
ExAC
gnomAD
rs756193741
CA2973928
118 V>A No ClinGen
ExAC
gnomAD
rs138558365
CA2973927
118 V>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA357454027
rs780055583
119 E>D No ClinGen
ExAC
gnomAD
CA100232738
rs762196941
121 I>T No ClinGen
Ensembl
CA357454049
rs1250232443
122 D>E No ClinGen
TOPMed
gnomAD
rs749821660
CA2973930
122 D>N No ClinGen
ExAC
gnomAD
CA357454070
rs779262291
125 F>L No ClinGen
ExAC
TOPMed
gnomAD
CA2973931
rs755411718
125 F>L No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 126 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs748531701
CA2973933
127 A>S No ClinGen
ExAC
gnomAD
rs771686832
CA2973934
129 L>M No ClinGen
ExAC
gnomAD
CA357454131
rs1354675965
134 K>R No ClinGen
gnomAD
rs149630228
CA2973935
136 K>I No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA100232740
rs866623127
137 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA2973936
rs746595068
142 Y>* No ClinGen
ExAC
gnomAD
CA357454182
rs1395707704
142 Y>N No ClinGen
gnomAD
rs1466044094
CA357454189
143 H>N No ClinGen
TOPMed
CA2973937
rs770596285
143 H>R No ClinGen
ExAC
gnomAD
rs1466044094
CA357454191
143 H>Y No ClinGen
TOPMed
rs776217889
CA2973938
145 T>M No ClinGen
ExAC
gnomAD
CA357454229
rs1469141733
148 H>Q No ClinGen
TOPMed
rs1578181224
CA357454227
148 H>R No ClinGen
Ensembl
rs1298384006
CA357454232
149 A>P No ClinGen
gnomAD
rs369111942
CA2973939
151 L>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA357454277
rs1489098591
155 A>G No ClinGen
gnomAD
rs1006675162
CA100232742
157 T>A No ClinGen
TOPMed
CA357454288
rs1215884568
157 T>I No ClinGen
gnomAD
CA357454309
rs1292542057
160 S>L No ClinGen
gnomAD
rs775495554
CA2973941
163 S>F No ClinGen
ExAC
TOPMed
gnomAD
rs762775423
CA2973942
164 L>R No ClinGen
ExAC
gnomAD
CA357454345
rs1419577271
167 V>I No ClinGen
gnomAD
rs767678053
CA2973943
168 T>S No ClinGen
ExAC
gnomAD
CA2973944
rs750676544
171 K>E No ClinGen
ExAC
TOPMed
gnomAD
CA357454377
rs1372365703
171 K>M No ClinGen
gnomAD
rs1461904769
CA357454378
171 K>N No ClinGen
TOPMed
gnomAD
rs1340457212
CA357454432
177 N>I No ClinGen
TOPMed
rs762747394
CA2973959
178 I>L No ClinGen
ExAC
TOPMed
gnomAD
rs762747394
CA357454435
178 I>V No ClinGen
ExAC
TOPMed
gnomAD
CA357454455
rs1291919722
181 I>V No ClinGen
gnomAD
CA2973962
rs200669230
188 I>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA2973961
rs567560732
188 I>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA2973964
rs753983158
190 K>E No ClinGen
ExAC
gnomAD
rs903013288
CA100233047
190 K>R No ClinGen
gnomAD
TCGA novel 191 N>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 192 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1255235586
CA357454567
197 K>R No ClinGen
gnomAD
CA2973965
rs759580405
198 S>R No ClinGen
ExAC
gnomAD
rs765253983
CA2973966
199 K>E No ClinGen
ExAC
gnomAD
CA2973967
rs547138375
201 M>V No ClinGen
1000Genomes
ExAC
gnomAD
rs758764668
CA2973968
204 L>V No ClinGen
ExAC
gnomAD
CA100233048
rs200002329
207 N>D No ClinGen
1000Genomes
rs778216469
CA2973969
207 N>S No ClinGen
ExAC
gnomAD
rs780964001
CA2973972
212 Y>D No ClinGen
ExAC
gnomAD
CA357454678
rs1471675211
213 Q>P No ClinGen
TOPMed
CA100233049
rs1035535345
219 E>G No ClinGen
Ensembl
rs769449041
CA357454730
220 T>K No ClinGen
ExAC
TOPMed
gnomAD
CA2973974
rs769449041
220 T>M No ClinGen
ExAC
TOPMed
gnomAD
rs1308026525
CA357454739
222 A>S No ClinGen
TOPMed
gnomAD
rs150623142
CA2973976
222 A>V No ClinGen
1000Genomes
ExAC
gnomAD
rs774260132
CA2973978
COSM196739
226 A>T Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
CA100233050
rs71661117
227 T>P No ClinGen
Ensembl
rs1294195244
CA357454777
228 M>V No ClinGen
TOPMed
CA2973980
rs771181394
229 S>N No ClinGen
ExAC
gnomAD
rs778682030
CA2973995
230 V>I No ClinGen
ExAC
TOPMed
gnomAD
rs1417923855
CA357454826
233 P>L No ClinGen
gnomAD
CA357454833
rs1409958373
234 F>C No ClinGen
gnomAD
rs1326993926
CA357454839
COSM1057745
235 A>V Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
gnomAD
rs771886566
CA2973997
237 V>I No ClinGen
ExAC
gnomAD
rs759768495
CA2973999
240 T>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs759768495
CA2974000
240 T>S No ClinGen
ExAC
TOPMed
gnomAD
CA357454871
rs1271441074
241 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
TCGA novel 242 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1190384708
CA357454905
245 I>T No ClinGen
TOPMed
CA2974005
rs376954304
246 G>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1466792562
CA357454908
246 G>S No ClinGen
gnomAD
TCGA novel 251 K>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357454953
rs1211623287
252 A>S No ClinGen
gnomAD
rs1341596863
CA357455038
262 V>A No ClinGen
TOPMed
CA2974030
rs773778323
263 E>K No ClinGen
ExAC
TOPMed
gnomAD
rs1311714703
CA357455076
267 H>Q No ClinGen
gnomAD
CA2974032
rs766103014
267 H>R No ClinGen
ExAC
gnomAD
CA357455079
rs1336182074
268 C>R No ClinGen
TOPMed
gnomAD
CA357455086
rs1277967112
269 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs933372079
CA100233649
271 V>L No ClinGen
Ensembl
CA2974035
rs764741944
274 R>Q No ClinGen
ExAC
TOPMed
gnomAD
CA2974036
rs752190171
276 M>T No ClinGen
ExAC
TOPMed
gnomAD
CA2974038
rs777660289
279 R>H No ClinGen
ExAC
gnomAD
rs1007223729
CA100233650
280 V>M No ClinGen
TOPMed
gnomAD
CA2974040
rs757027706
281 N>T No ClinGen
ExAC
gnomAD
CA100233652
rs377563788
286 R>G No ClinGen
ESP
CA2974041
rs780997520
286 R>Q No ClinGen
ExAC
gnomAD
rs749473915
CA2974042
288 Q>E No ClinGen
ExAC
gnomAD
rs1173713183
CA357455220
289 T>P No ClinGen
gnomAD
rs774626655
CA2974044
290 H>N No ClinGen
ExAC
CA2974045
rs748232949
290 H>P No ClinGen
ExAC
gnomAD
rs200976530
CA2974046
291 T>P No ClinGen
ExAC
gnomAD
rs914075587
CA100233654
292 R>C No ClinGen
TOPMed
gnomAD
COSM1196329
CA2974047
rs773831318
292 R>H lung [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA2974049
rs771206259
294 Y>C No ClinGen
ExAC
gnomAD
CA100233655
rs1044354740
295 E>Q No ClinGen
TOPMed
rs900108257
CA100233656
299 R>C No ClinGen
TOPMed
gnomAD
rs759170909
CA2974051
299 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs529122060
CA2974052
301 K>E No ClinGen
1000Genomes
ExAC
gnomAD
CA357455298
rs752247253
301 K>R No ClinGen
ExAC
TOPMed
gnomAD
rs752247253
CA2974053
301 K>T No ClinGen
ExAC
TOPMed
gnomAD
rs1194423614
CA357455303
302 L>V No ClinGen
gnomAD
CA2974054
rs762430454
303 E>D No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 304 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2974055
rs763550483
304 E>Q No ClinGen
ExAC
gnomAD
rs1195297439
CA357455328
305 M>I No ClinGen
TOPMed
rs1193932862
CA357455323
305 M>V No ClinGen
gnomAD
CA357455354
rs1324280265
309 D>H No ClinGen
TOPMed
CA357455363
rs1560740881
310 T>S No ClinGen
Ensembl
CA357455371
rs1254522164
311 D>G No ClinGen
gnomAD
CA2974056
rs374124952
312 P>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs750216211
CA2974059
317 F>L No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 320 Q>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357455446
rs1204820192
320 Q>E No ClinGen
TOPMed
CA2974081
rs779945546
323 Y>* No ClinGen
ExAC
gnomAD
rs1282228946
CA357455485
325 A>E No ClinGen
gnomAD
rs1356667896
CA357455507
328 N>S No ClinGen
gnomAD
TCGA novel 329 E>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357455535
rs1235467440
332 G>E No ClinGen
TOPMed
gnomAD
rs150688245
CA2974083
337 K>N No ClinGen
1000Genomes
ExAC
gnomAD
rs752998062
CA2974082
337 K>R No ClinGen
ExAC
gnomAD
rs200457354
CA2974084
343 Q>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA2974087
rs771384009
344 M>I No ClinGen
ExAC
gnomAD
TCGA novel 344 M>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2974086
rs747109761
344 M>T No ClinGen
ExAC
TOPMed
gnomAD
rs370011814
CA100234466
344 M>V No ClinGen
ESP
gnomAD
rs1299078693
CA357455641
347 M>V No ClinGen
TOPMed
CA357455694
rs1475502108
354 A>T No ClinGen
gnomAD
CA357455722
rs1437708754
358 E>K No ClinGen
TOPMed
rs1021452483
CA100234468
359 A>G No ClinGen
Ensembl
CA357455731
rs1411407881
359 A>S No ClinGen
gnomAD
CA357455758
rs1347214189
362 E>D No ClinGen
gnomAD
CA357455752
rs1325097312
362 E>Q No ClinGen
TOPMed
COSM1057747
rs780450396
CA2974109
365 E>K Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
CA99905386
rs553968886
369 L>F No ClinGen
gnomAD
rs768230308
CA2974111
372 R>Q No ClinGen
ExAC
TOPMed
gnomAD
CA2974112
rs774031568
376 E>Q No ClinGen
ExAC
gnomAD
CA357353002
CA357353003
rs1307871901
384 K>N No ClinGen
gnomAD
rs369007706
CA2974113
384 K>T No ClinGen
ESP
ExAC
gnomAD
rs1378638278 386 K>missing Variant assessed as Somatic; 4.63e-05 impact. [NCI-TCGA] No NCI-TCGA
rs892717514
CA99905414
387 E>D No ClinGen
Ensembl
CA2974115
rs772529752
394 N>K No ClinGen
ExAC
gnomAD
rs771644039
CA2974114
394 N>S No ClinGen
ExAC
gnomAD
CA357353315
rs1193959141
400 A>G No ClinGen
gnomAD
CA357353334
rs1204946414
401 A>V No ClinGen
TOPMed
gnomAD
rs776609345
CA2974118
406 Q>E No ClinGen
ExAC
TOPMed
gnomAD
CA357353432
rs1253887695
406 Q>H No ClinGen
gnomAD
CA357353504
rs1170897864
410 Q>* No ClinGen
gnomAD
rs1411073748
CA357353597
414 A>G No ClinGen
TOPMed
gnomAD
rs764894616
CA357353591
414 A>S No ClinGen
ExAC
TOPMed
gnomAD
rs764894616
CA2974120
414 A>T No ClinGen
ExAC
TOPMed
gnomAD
rs1411073748
CA357353601
414 A>V No ClinGen
TOPMed
gnomAD
rs1172948081
CA357353612
415 Q>* No ClinGen
gnomAD
TCGA novel 418 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA357353858
rs1345157867
422 D>Y No ClinGen
TOPMed
TCGA novel 423 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1362247163
CA357353954
424 K>R No ClinGen
gnomAD
rs760719379
CA2974145
429 T>A No ClinGen
ExAC
gnomAD

1 associated diseases with Q9NVA2

Without disease ID

1 regional properties for Q9NVA2

Type Name Position InterPro Accession
domain Septin-type guanine nucleotide-binding (G) domain 38 - 307 IPR030379

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Synapse
  • Cell projection, dendritic spine
  • Cell projection, axon
  • Partly colocalizes with stress fibers and microtubules
  • During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
septin complex A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

2 GO annotations of biological process

Name Definition
cytoskeleton-dependent cytokinesis A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32468 CDC12 Cell division control protein 12 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q07657 SHS1 Seventh homolog of septin 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32457 CDC3 Cell division control protein 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A6QQL3 SEPTIN14 Septin-14 Bos taurus (Bovine) PR
Q3SZN0 SEPTIN6 Septin-6 Bos taurus (Bovine) PR
A2VE99 SEPTIN11 Septin-11 Bos taurus (Bovine) PR
P54359 02-Sep Septin-2 Drosophila melanogaster (Fruit fly) PR
Q16181 SEPTIN7 Septin-7 Homo sapiens (Human) PR
Q14141 SEPTIN6 Septin-6 Homo sapiens (Human) PR
Q9P0V9 SEPTIN10 Septin-10 Homo sapiens (Human) PR
Q9UH03 SEPTIN3 Neuronal-specific septin-3 Homo sapiens (Human) PR
Q9UHD8 SEPTIN9 Septin-9 Homo sapiens (Human) PR
Q8CHH9 Septin8 Septin-8 Mus musculus (Mouse) PR
Q9DA97 Septin14 Septin-14 Mus musculus (Mouse) PR
Q9R1T4 Septin6 Septin-6 Mus musculus (Mouse) PR
Q8C1B7 Septin11 Septin-11 Mus musculus (Mouse) PR
B0BNF1 Septin8 Septin-8 Rattus norvegicus (Rat) PR
B3GNI6 Septin11 Septin-11 Rattus norvegicus (Rat) PR
A4FUM1 sept8b Septin-8-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q642H3 sept8a Septin-8-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET GIGKSTLMDT
70 80 90 100 110 120
LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD TVGFGDQINK DDSYKPIVEY
130 140 150 160 170 180
IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP
190 200 210 220 230 240
IIAKADTIAK NELHKFKSKI MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST
250 260 270 280 290 300
EEVKIGNKMA KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC
310 320 330 340 350 360
KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK EKEAELKEAE
370 380 390 400 410 420
KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVNNFQKKKA AAQLLQSQAQ QSGAQQTKKD
KDKKNASFT