P25342
PR
Gene name |
CDC10 (YCR002C, YCR022, YCR2C) |
Protein name |
Cell division control protein 10 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YCR002C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P25342
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8FWP | X-ray | 222 A | A | 30-302 | PDB |
| 8SGD | X-ray | 266 A | A/C | 11-322 | PDB |
| AF-P25342-F1 | Predicted | AlphaFoldDB |
3 variants for P25342
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s03-118340 | 3 | P>S | No | SGRP | |
| s03-118271 | 26 | L>M | No | SGRP | |
| s03-117712 | 212 | S>L | No | SGRP |
No associated diseases with P25342
1 regional properties for P25342
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Septin-type guanine nucleotide-binding (G) domain | 29 - 307 | IPR030379 |
Functions
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| ascospore wall | The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi. |
| ascospore-type prospore | An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud neck septin ring | A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. |
| Gin4 complex | A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved. |
| mating projection base | The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. |
| mating projection tip | The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. |
| meiotic spindle | A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| prospore membrane | The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. |
| septin complex | A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. |
| septin filament array | Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. |
| septin ring | A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. |
| spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol binding | Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| phosphatidylinositol-4-phosphate binding | Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| phosphatidylinositol-5-phosphate binding | Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular bud neck septin ring organization | Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. |
| cytoskeleton-dependent cytokinesis | A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. |
| exit from mitosis | The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. |
| maintenance of cell polarity | The maintenance of established anisotropic intracellular organization or cell growth patterns. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| positive regulation of protein serine/threonine kinase activity | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| septin ring assembly | The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex. |
| septum digestion after cytokinesis | The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. |
| sporulation | The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32457 | CDC3 | Cell division control protein 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32468 | CDC12 | Cell division control protein 12 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q07657 | SHS1 | Seventh homolog of septin 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08DM7 | SEPTIN3 | Neuronal-specific septin-3 | Bos taurus (Bovine) | PR |
| Q9UH03 | SEPTIN3 | Neuronal-specific septin-3 | Homo sapiens (Human) | PR |
| Q9UHD8 | SEPTIN9 | Septin-9 | Homo sapiens (Human) | PR |
| Q9Z1S5 | Septin3 | Neuronal-specific septin-3 | Mus musculus (Mouse) | PR |
| Q80UG5 | Septin9 | Septin-9 | Mus musculus (Mouse) | PR |
| Q9WU34 | Septin3 | Neuronal-specific septin-3 | Rattus norvegicus (Rat) | PR |
| Q9QZR6 | Septin9 | Septin-9 | Rattus norvegicus (Rat) | PR |
| A2BGU8 | septin3 | Neuronal-specific septin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPLSSVQPA | SYVGFDTITN | QIEHRLLKKG | FQFNIMVVGQ | SGLGKSTLIN | TLFASHLIDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ATGDDISALP | VTKTTEMKIS | THTLVEDRVR | LNINVIDTPG | FGDFIDNSKA | WEPIVKYIKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QHSQYLRKEL | TAQRERFITD | TRVHAILYFL | QPNGKELSRL | DVEALKRLTE | IANVIPVIGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDTLTLDERT | EFRELIQNEF | EKYNFKIYPY | DSEELTDEEL | ELNRSVRSII | PFAVVGSENE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IEINGETFRG | RKTRWSAINV | EDINQCDFVY | LREFLIRTHL | QDLIETTSYI | HYEGFRARQL |
| 310 | 320 | ||||
| IALKENANSR | SSAHMSSNAI | QR |