Q9WU34
Gene name |
Septin3 |
Protein name |
Neuronal-specific septin-3 |
Names |
G-septin, P40 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:56003 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WU34
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WU34-F1 | Predicted | AlphaFoldDB |
No variants for Q9WU34
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WU34 | |||||
No associated diseases with Q9WU34
1 regional properties for Q9WU34
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Septin-type guanine nucleotide-binding (G) domain | 58 - 331 | IPR030379 |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| presynaptic cytoskeleton | The portion of the cytoskeleton contained within the presynapse. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
| septin complex | A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. |
| septin ring | A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoskeleton-dependent cytokinesis | A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25342 | CDC10 | Cell division control protein 10 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08DM7 | SEPTIN3 | Neuronal-specific septin-3 | Bos taurus (Bovine) | PR |
| Q9UHD8 | SEPTIN9 | Septin-9 | Homo sapiens (Human) | PR |
| Q9UH03 | SEPTIN3 | Neuronal-specific septin-3 | Homo sapiens (Human) | PR |
| Q80UG5 | Septin9 | Septin-9 | Mus musculus (Mouse) | PR |
| Q9Z1S5 | Septin3 | Neuronal-specific septin-3 | Mus musculus (Mouse) | PR |
| Q9WVC0 | Septin7 | Septin-7 | Rattus norvegicus (Rat) | PR |
| B3GNI6 | Septin11 | Septin-11 | Rattus norvegicus (Rat) | PR |
| B0BNF1 | Septin8 | Septin-8 | Rattus norvegicus (Rat) | PR |
| Q9QZR6 | Septin9 | Septin-9 | Rattus norvegicus (Rat) | PR |
| A2BGU8 | septin3 | Neuronal-specific septin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKGLPEART | DTAMSELVPE | PRPKPAVPMK | PVSINSNLLG | CIGIDTIIEQ | MRKKTMKTGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DFNIMVVGQS | GLGKSTLVNT | LFKSQVSRKA | SSWNREEKIP | KTVEIKAIGH | VIEEGGVKMK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTVIDTPGFG | DQINNENCWE | PIEKYINEQY | EKFLKEEVNI | ARKKRIPDTR | VHCCLYFISP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGHSLRPLDL | EFMKHLSKVV | NVIPVIAKAD | TMTLEEKSEF | KQRVRKELEV | NGIEFYPQKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FDEDLEDKTE | NDKIRQESMP | FAVVGSDKEY | QVNGKRVLGR | KTPWGIIEVE | NLNHCEFALL |
| 310 | 320 | 330 | 340 | 350 | |
| RDFVIRTHLQ | DLKEVTHNIH | YETYRAKRLN | DNGGLPPGEG | LLGTVLPPVP | ATPCPTAE |