Q9VZ23
PR
Gene name |
Ran |
Protein name |
GTP-binding nuclear protein Ran |
Names |
Ras-related nuclear protein |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG1404 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VZ23
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VZ23-F1 | Predicted | AlphaFoldDB |
No variants for Q9VZ23
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VZ23 | |||||
No associated diseases with Q9VZ23
6 regional properties for Q9VZ23
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | GTF2I-like repeat | 119 - 213 | IPR004212-1 |
| repeat | GTF2I-like repeat | 342 - 436 | IPR004212-2 |
| repeat | GTF2I-like repeat | 556 - 650 | IPR004212-3 |
| repeat | GTF2I-like repeat | 681 - 775 | IPR004212-4 |
| repeat | GTF2I-like repeat | 805 - 899 | IPR004212-5 |
| repeat | GTF2I-like repeat | 908 - 1002 | IPR004212-6 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitotic spindle microtubule | Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. |
| NLS-dependent protein nuclear import complex | A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| metal ion binding | Binding to a metal ion. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| meiotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. |
| nuclear export | The directed movement of substances out of the nucleus. |
| nuclear pore complex assembly | The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. |
| positive regulation of protein-containing complex disassembly | Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. |
| protein export from nucleus | The directed movement of a protein from the nucleus into the cytoplasm. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
| ribosomal subunit export from nucleus | The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32836 | GSP2 | GTP-binding nuclear protein GSP2/CNR2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32835 | GSP1 | GTP-binding nuclear protein GSP1/CNR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P42558 | RAN | GTP-binding nuclear protein Ran | Gallus gallus (Chicken) | PR |
| Q7F7I7 | RAN1 | GTP-binding nuclear protein Ran-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q7GD79 | RAN2 | GTP-binding nuclear protein Ran-2 | Oryza sativa subsp japonica (Rice) | PR |
| O17915 | ran-1 | GTP-binding nuclear protein ran-1 | Caenorhabditis elegans | PR |
| P41916 | RAN1 | GTP-binding nuclear protein Ran-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41917 | RAN2 | GTP-binding nuclear protein Ran-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H156 | RAN3 | GTP-binding nuclear protein Ran-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P38546 | RAN1 | GTP-binding nuclear protein Ran1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P38547 | RAN2 | GTP-binding nuclear protein Ran2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| Q6GL85 | ran | GTP-binding nuclear protein Ran | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQEGQDIPT | FKCVLVGDGG | TGKTTFVKRH | MTGEFEKKYV | ATLGVEVHPL | IFHTNRGAIR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FNVWDTAGQE | KFGGLRDGYY | IQGQCAVIMF | DVTSRVTYKN | VPNWHRDLVR | VCENIPIVLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNKVDIKDRK | VKAKSIVFHR | KKNLQYYDIS | AKSNYNFEKP | FLWLARKLVG | DPNLEFVAMP |
| 190 | 200 | 210 | |||
| ALLPPEVKMD | KDWQAQIERD | LQEAQATALP | DEDEEL |