P32835
Gene name |
GSP1 (CNR1, CST17, YLR293C, L8003.19) |
Protein name |
GTP-binding nuclear protein GSP1/CNR1 |
Names |
Chromosome stability protein 17, GTPase Ran homolog, Genetic suppressor of PRP20-1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR293C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
9 structures for P32835
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2X19 | X-ray | 280 A | A | 8-179 | PDB |
| 3ICQ | X-ray | 320 A | B/C | 9-179 | PDB |
| 3M1I | X-ray | 200 A | A | 1-219 | PDB |
| 3WYG | X-ray | 215 A | A | 1-182 | PDB |
| 8DYO | EM | 710 A | B | 1-219 | PDB |
| 8F19 | EM | 349 A | B | 1-179 | PDB |
| 8F1E | EM | 328 A | D | 1-179 | PDB |
| 8F7A | EM | 378 A | B | 1-219 | PDB |
| AF-P32835-F1 | Predicted | AlphaFoldDB |
No variants for P32835
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P32835 | |||||
No associated diseases with P32835
6 regional properties for P32835
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | GTF2I-like repeat | 103 - 197 | IPR004212-1 |
| repeat | GTF2I-like repeat | 352 - 446 | IPR004212-2 |
| repeat | GTF2I-like repeat | 457 - 551 | IPR004212-3 |
| repeat | GTF2I-like repeat | 562 - 656 | IPR004212-4 |
| repeat | GTF2I-like repeat | 724 - 818 | IPR004212-5 |
| repeat | GTF2I-like repeat | 859 - 953 | IPR004212-6 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| nucleus organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. |
| poly(A)+ mRNA export from nucleus | The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| regulation of cell cycle phase transition | Any process that modulates the frequency, rate or extent of cell cycle phase transition. |
| regulation of nucleocytoplasmic transport | Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. |
| ribosomal subunit export from nucleus | The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32836 | GSP2 | GTP-binding nuclear protein GSP2/CNR2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P42558 | RAN | GTP-binding nuclear protein Ran | Gallus gallus (Chicken) | PR |
| Q9VZ23 | Ran | GTP-binding nuclear protein Ran | Drosophila melanogaster (Fruit fly) | PR |
| Q7GD79 | RAN2 | GTP-binding nuclear protein Ran-2 | Oryza sativa subsp japonica (Rice) | PR |
| Q7F7I7 | RAN1 | GTP-binding nuclear protein Ran-1 | Oryza sativa subsp japonica (Rice) | PR |
| O17915 | ran-1 | GTP-binding nuclear protein ran-1 | Caenorhabditis elegans | PR |
| Q8H156 | RAN3 | GTP-binding nuclear protein Ran-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41916 | RAN1 | GTP-binding nuclear protein Ran-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41917 | RAN2 | GTP-binding nuclear protein Ran-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P38546 | RAN1 | GTP-binding nuclear protein Ran1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P38547 | RAN2 | GTP-binding nuclear protein Ran2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| Q6GL85 | ran | GTP-binding nuclear protein Ran | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAPAANGEV | PTFKLVLVGD | GGTGKTTFVK | RHLTGEFEKK | YIATIGVEVH | PLSFYTNFGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IKFDVWDTAG | QEKFGGLRDG | YYINAQCAII | MFDVTSRITY | KNVPNWHRDL | VRVCENIPIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LCGNKVDVKE | RKVKAKTITF | HRKKNLQYYD | ISAKSNYNFE | KPFLWLARKL | AGNPQLEFVA |
| 190 | 200 | 210 | |||
| SPALAPPEVQ | VDEQLMQQYQ | QEMEQATALP | LPDEDDADL |