P41917

PR
Gene name
RAN2
Protein name
GTP-binding nuclear protein Ran-2
Names
Ras-related nuclear protein 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G20020
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41917

Entry ID Method Resolution Chain Position Source
AF-P41917-F1 Predicted AlphaFoldDB

1 variants for P41917

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH10872792 209 A>S No 1000Genomes

No associated diseases with P41917

1 regional properties for P41917

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 14 - 164 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus envelope
  • Localized in the perinuclear region with the highest concentration at the nuclear envelope at the interphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

2 GO annotations of biological process

Name Definition
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
ribosomal subunit export from nucleus The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32836 GSP2 GTP-binding nuclear protein GSP2/CNR2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32835 GSP1 GTP-binding nuclear protein GSP1/CNR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P42558 RAN GTP-binding nuclear protein Ran Gallus gallus (Chicken) PR
Q9VZ23 Ran GTP-binding nuclear protein Ran Drosophila melanogaster (Fruit fly) PR
Q7F7I7 RAN1 GTP-binding nuclear protein Ran-1 Oryza sativa subsp japonica (Rice) PR
Q7GD79 RAN2 GTP-binding nuclear protein Ran-2 Oryza sativa subsp japonica (Rice) PR
O17915 ran-1 GTP-binding nuclear protein ran-1 Caenorhabditis elegans PR
P41916 RAN1 GTP-binding nuclear protein Ran-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8H156 RAN3 GTP-binding nuclear protein Ran-3 Arabidopsis thaliana (Mouse-ear cress) PR
P38546 RAN1 GTP-binding nuclear protein Ran1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P38547 RAN2 GTP-binding nuclear protein Ran2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
Q6GL85 ran GTP-binding nuclear protein Ran Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV HPLDFFTNCG
70 80 90 100 110 120
KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT YKNVPTWHRD LCRVCENIPI
130 140 150 160 170 180
VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY EISAKSNYNF EKPFLYLARK LAGDQNLHFV
190 200 210 220
ESPALAPPEV HLDIAAQQQN EADLAAAAAQ PLPDDDDDAF E