Q6GL85
Gene name |
ran |
Protein name |
GTP-binding nuclear protein Ran |
Names |
GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:448091 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GL85
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GL85-F1 | Predicted | AlphaFoldDB |
No variants for Q6GL85
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6GL85 | |||||
No associated diseases with Q6GL85
1 regional properties for Q6GL85
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 11 - 159 | IPR005225 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| GTP metabolic process | The chemical reactions and pathways involving GTP, guanosine triphosphate. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| ribosomal subunit export from nucleus | The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. |
| snRNA import into nucleus | The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32836 | GSP2 | GTP-binding nuclear protein GSP2/CNR2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32835 | GSP1 | GTP-binding nuclear protein GSP1/CNR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P42558 | RAN | GTP-binding nuclear protein Ran | Gallus gallus (Chicken) | PR |
| Q9VZ23 | Ran | GTP-binding nuclear protein Ran | Drosophila melanogaster (Fruit fly) | PR |
| Q7GD79 | RAN2 | GTP-binding nuclear protein Ran-2 | Oryza sativa subsp japonica (Rice) | PR |
| Q7F7I7 | RAN1 | GTP-binding nuclear protein Ran-1 | Oryza sativa subsp japonica (Rice) | PR |
| O17915 | ran-1 | GTP-binding nuclear protein ran-1 | Caenorhabditis elegans | PR |
| Q8H156 | RAN3 | GTP-binding nuclear protein Ran-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41916 | RAN1 | GTP-binding nuclear protein Ran-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41917 | RAN2 | GTP-binding nuclear protein Ran-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P38546 | RAN1 | GTP-binding nuclear protein Ran1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P38547 | RAN2 | GTP-binding nuclear protein Ran2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAQGEPQVQ | FKLVLVGDGG | TGKTTFVKRH | LTGEFEKKYV | ATLGVEVHPL | VFHTNRGPIK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FNVWDTAGQE | KFGGLRDGYY | IQAQCAIIMF | DVTSRVTYKN | VPNWHRDLVR | VCENIPIVLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNKVDIKDRK | VKAKSIVFHR | KKNLQYYDIS | AKSNYNFEKP | FLWLARKLIG | DPNFEFVAMP |
| 190 | 200 | 210 | |||
| ALAPPEVVMD | PALAAQYEQD | LQHAQATALP | DEDDDL |