O17915

PR
Gene name
ran-1 (K01G5.4)
Protein name
GTP-binding nuclear protein ran-1
Names
Ras-related nuclear protein 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K01G5.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

146-215 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O17915

Entry ID Method Resolution Chain Position Source
AF-O17915-F1 Predicted AlphaFoldDB

No variants for O17915

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O17915

No associated diseases with O17915

1 regional properties for O17915

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 9 - 158 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere, kinetochore
  • Chromosome
  • At interphase, ran-1 is localized to the nucleus and the nuclear envelope
  • At prometaphase, ran-1 is still localized to the nuclear envelope
  • When the nuclear envelope begins to disassemble at M phase (early metaphase), ran-1 is localized throughout the entire cell
  • At late metaphase, ran-1 localizes to the kinetochore regions, this persists until anaphase
  • At telophase, ran-1 is localized around the decondensing chromosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

6 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
ribosomal subunit export from nucleus The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32836 GSP2 GTP-binding nuclear protein GSP2/CNR2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32835 GSP1 GTP-binding nuclear protein GSP1/CNR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P42558 RAN GTP-binding nuclear protein Ran Gallus gallus (Chicken) PR
Q9VZ23 Ran GTP-binding nuclear protein Ran Drosophila melanogaster (Fruit fly) PR
Q7F7I7 RAN1 GTP-binding nuclear protein Ran-1 Oryza sativa subsp japonica (Rice) PR
Q7GD79 RAN2 GTP-binding nuclear protein Ran-2 Oryza sativa subsp japonica (Rice) PR
P41916 RAN1 GTP-binding nuclear protein Ran-1 Arabidopsis thaliana (Mouse-ear cress) PR
P41917 RAN2 GTP-binding nuclear protein Ran-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8H156 RAN3 GTP-binding nuclear protein Ran-3 Arabidopsis thaliana (Mouse-ear cress) PR
P38546 RAN1 GTP-binding nuclear protein Ran1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P38547 RAN2 GTP-binding nuclear protein Ran2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
Q6GL85 ran GTP-binding nuclear protein Ran Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSGGDGIPTF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLV FHTNRGQIRF
70 80 90 100 110 120
NVWDTAGQEK FGGLRDGYYI QGQCAIIMFD VTARVTYKNV PNWHRDLARV CENIPIVLCG
130 140 150 160 170 180
NKVDVKDRKV KAKTITFHRK KNLQYYDISA KSNYNFEKPF LWLARKLLGD PNLEFVAMPA
190 200 210
LAPPEVQMDP AMIAEYEKDL DNAAKADLPD DDDDL