P41916
Gene name |
RAN1 (At5g20010, F28I16.160) |
Protein name |
GTP-binding nuclear protein Ran-1 |
Names |
Ras-related nuclear protein 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G20010 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P41916
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P41916-F1 | Predicted | AlphaFoldDB |
5 variants for P41916
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_6760543_A_G | 10 | D>G | No | 1000Genomes | |
| tmp_5_6760552_G_A | 13 | S>N | No | 1000Genomes | |
| tmp_5_6761395_C_A | 105 | P>Q | No | 1000Genomes | |
| ENSVATH06998979 | 191 | H>Y | No | 1000Genomes | |
| ENSVATH14100526 | 192 | I>F | No | 1000Genomes |
No associated diseases with P41916
1 regional properties for P41916
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 14 - 164 | IPR005225 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| apoplast | The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| ribosomal subunit export from nucleus | The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32836 | GSP2 | GTP-binding nuclear protein GSP2/CNR2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32835 | GSP1 | GTP-binding nuclear protein GSP1/CNR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P42558 | RAN | GTP-binding nuclear protein Ran | Gallus gallus (Chicken) | PR |
| Q9VZ23 | Ran | GTP-binding nuclear protein Ran | Drosophila melanogaster (Fruit fly) | PR |
| Q7F7I7 | RAN1 | GTP-binding nuclear protein Ran-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q7GD79 | RAN2 | GTP-binding nuclear protein Ran-2 | Oryza sativa subsp japonica (Rice) | PR |
| O17915 | ran-1 | GTP-binding nuclear protein ran-1 | Caenorhabditis elegans | PR |
| P41917 | RAN2 | GTP-binding nuclear protein Ran-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H156 | RAN3 | GTP-binding nuclear protein Ran-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P38546 | RAN1 | GTP-binding nuclear protein Ran1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P38547 | RAN2 | GTP-binding nuclear protein Ran2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| Q6GL85 | ran | GTP-binding nuclear protein Ran | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALPNQQTVD | YPSFKLVIVG | DGGTGKTTFV | KRHLTGEFEK | KYEPTIGVEV | HPLDFFTNCG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIRFYCWDTA | GQEKFGGLRD | GYYIHGQCAI | IMFDVTARLT | YKNVPTWHRD | LCRVCENIPI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLCGNKVDVK | NRQVKAKQVT | FHRKKNLQYY | EISAKSNYNF | EKPFLYLARK | LAGDQNLHFV |
| 190 | 200 | 210 | 220 | ||
| ETPALAPPEV | HIDIADQQKN | EAELLQAAAQ | PLPDDDDDIF | E |