Q9STZ3

PR
Gene name
PLC8 (PLC2, At3g47290, T21L8.40)
Protein name
Phosphoinositide phospholipase C 8
Names
Phosphoinositide phospholipase PLC8, AtPLC8, PI-PLC8
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G47290
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9STZ3

Entry ID Method Resolution Chain Position Source
AF-Q9STZ3-F1 Predicted AlphaFoldDB

76 variants for Q9STZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_17420627_G_A 8 E>K No 1000Genomes
tmp_3_17420660_T_G 19 L>V No 1000Genomes
ENSVATH06257564 21 F>Y No 1000Genomes
tmp_3_17420670_T_G 22 F>C No 1000Genomes
ENSVATH12605117 33 M>L No 1000Genomes
tmp_3_17420712_C_G 36 T>R No 1000Genomes
tmp_3_17420718_G_A 38 R>Q No 1000Genomes
ENSVATH14391507 50 E>D No 1000Genomes
tmp_3_17420763_C_T 53 A>V No 1000Genomes
ENSVATH00405126 70 D>G No 1000Genomes
tmp_3_17420813_G_A 70 D>N No 1000Genomes
ENSVATH14391509 73 P>L No 1000Genomes
tmp_3_17420826_C_A 74 A>D No 1000Genomes
tmp_3_17420835_G_C 77 R>P No 1000Genomes
tmp_3_17420834_C_A 77 R>S No 1000Genomes
tmp_3_17420841_G_A,C 79 R>P No 1000Genomes
tmp_3_17420841_G_A,C 79 R>Q No 1000Genomes
tmp_3_17420850_A_G 82 E>G No 1000Genomes
ENSVATH00405128 82 E>K No 1000Genomes
tmp_3_17420855_G_T,A 84 D>N No 1000Genomes
tmp_3_17420855_G_T,A 84 D>Y No 1000Genomes
tmp_3_17420860_G_C 85 Q>H No 1000Genomes
tmp_3_17420886_A_C 94 K>T No 1000Genomes
tmp_3_17421430_T_G 103 V>G No 1000Genomes
tmp_3_17421432_C_T 104 H>Y No 1000Genomes
tmp_3_17421520_G_T 133 S>I No 1000Genomes
ENSVATH00405136 157 R>K No 1000Genomes
ENSVATH12605170 159 S>N No 1000Genomes
tmp_3_17421619_G_A 166 W>* No 1000Genomes
ENSVATH00405137 168 F>L No 1000Genomes
ENSVATH12605171 175 Q>H No 1000Genomes
tmp_3_17421744_T_C 181 I>T No 1000Genomes
tmp_3_17421756_C_T 185 A>V No 1000Genomes
tmp_3_17421809_C_A 203 P>T No 1000Genomes
tmp_3_17421945_C_T 216 T>I No 1000Genomes
ENSVATH06257591 228 S>R No 1000Genomes
ENSVATH06257592 231 V>D No 1000Genomes
tmp_3_17422013_C_A,T 239 R>* No 1000Genomes
ENSVATH00405141 264 V>E No 1000Genomes
tmp_3_17422119_C_T 274 P>L No 1000Genomes
tmp_3_17422191_T_G 298 L>* No 1000Genomes
tmp_3_17422194_C_T 299 T>I No 1000Genomes
ENSVATH00405143 303 N>S No 1000Genomes
tmp_3_17422416_C_T 340 P>S No 1000Genomes
ENSVATH12605180 357 E>D No 1000Genomes
ENSVATH02459908 358 E>D No 1000Genomes
tmp_3_17422668_G_C 364 L>F No 1000Genomes
ENSVATH14391535 368 M>L No 1000Genomes
ENSVATH12605181 370 R>S No 1000Genomes
tmp_3_17422711_A_C 379 K>Q No 1000Genomes
ENSVATH14391536 380 K>E No 1000Genomes
ENSVATH06257607 389 P>S No 1000Genomes
ENSVATH06257608 396 T>I No 1000Genomes
tmp_3_17422879_G_A 413 D>N No 1000Genomes
ENSVATH02459911 421 K>E No 1000Genomes
ENSVATH06257612 424 G>S No 1000Genomes
tmp_3_17423040_G_A 436 S>N No 1000Genomes
ENSVATH14391542 443 D>G No 1000Genomes
ENSVATH08145834 445 N>K No 1000Genomes
ENSVATH08145835 447 M>T No 1000Genomes
ENSVATH08145836 448 K>N No 1000Genomes
ENSVATH12605236 451 V>G No 1000Genomes
ENSVATH12605235 451 V>M No 1000Genomes
ENSVATH02459925 457 T>K No 1000Genomes
ENSVATH06257616 472 D>N No 1000Genomes
ENSVATH02459929 485 V>I No 1000Genomes
ENSVATH06257617 486 S>L No 1000Genomes
ENSVATH06257618 487 T>S No 1000Genomes
ENSVATH02459930 488 A>P No 1000Genomes
ENSVATH02459930 488 A>T No 1000Genomes
ENSVATH02459931 490 A>E No 1000Genomes
tmp_3_17423201_G_T 490 A>S No 1000Genomes
ENSVATH02459933 504 E>Q No 1000Genomes
ENSVATH12605239 515 R>G No 1000Genomes
tmp_3_17423284_G_C 517 K>N No 1000Genomes
ENSVATH00405150 520 S>R No 1000Genomes

No associated diseases with Q9STZ3

13 regional properties for Q9STZ3

Type Name Position InterPro Accession
domain C2 domain 1 - 117 IPR000008
domain Protein kinase domain 408 - 668 IPR000719
domain AGC-kinase, C-terminal 669 - 737 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 169 - 221 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 242 - 294 IPR002219-2
active_site Serine/threonine-protein kinase, active site 528 - 540 IPR008271
binding_site Protein kinase, ATP binding site 414 - 437 IPR017441
domain Protein kinase, C-terminal 689 - 730 IPR017892
domain Diacylglycerol/phorbol-ester binding 167 - 181 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 183 - 192 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 197 - 208 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 281 - 293 IPR020454-4
domain Novel protein kinase C epsilon, catalytic domain 412 - 732 IPR034669

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

43 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q00722 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Homo sapiens (Human) EV
Q01970 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Homo sapiens (Human) EV
Q9NQ66 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Homo sapiens (Human) EV
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q15147 PLCB4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10686 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Rattus norvegicus (Rat) EV
P24135 Plcg2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Rattus norvegicus (Rat) SS
O89040 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Rattus norvegicus (Rat) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
P10687 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q99JE6 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Rattus norvegicus (Rat) SS
G5EBH0 egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Caenorhabditis elegans SS
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MLVTRRWESH PANSPDLILQ FFGNEFHGYG DDMPETLRRL TELLGYEKEE DGAGMNAAKK
70 80 90 100 110 120
IAAELNRRKD DIPAFRRLRC LELDQLNEFL FSTKLNPPIG DQVHHDMHAP LSHYFIHTSL
130 140 150 160 170 180
NSYFTGNVFG KYSILPIIEA LEQGVRVVEL DLWPDGRGSI CVRPSWNFEK PLKLQECLDS
190 200 210 220 230 240
IKEHAFTKCT YPLIITFKDG LKPELQSKAT QMIQQTFNHM VYHHDPHSLE VFPSPQQLRN
250 260 270 280 290 300
KILISRRPPK ELLYANDDDG KVGVRNGVEI RQHPADPNYQ SLVSFHVVEP RGMLQNVLTG
310 320 330 340 350 360
KANKIQRPGW YETDIISFTQ KRFLRTRPQR KLLIYAPYKP QRAWMHGAQL IALSRKEEKE
370 380 390 400 410 420
KLWLMQGMFR ANGGCGYVKK PDFLLNAGPS GVFYPTVNPV VVKILKVKIY MGDGWIVDFK
430 440 450 460 470 480
KRIGRLSKPD LYVRISIAGV PHDENIMKTT VKNNEWTPTW GEEFTFPLTY PDLALISFEV
490 500 510 520 530
YDYEVSTADA FCGQTCLPVS ELIEGIRAVP LYDERGKACS STMLLTRFKW S