Q8K394

PR
Gene name
Plcl2 (Kiaa1092, Plce2)
Protein name
Inactive phospholipase C-like protein 2
Names
PLC-L(2), PLC-L2, Phospholipase C-L2, Phospholipase C-epsilon-2, PLC-epsilon-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:224860
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-122 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K394

Entry ID Method Resolution Chain Position Source
AF-Q8K394-F1 Predicted AlphaFoldDB

58 variants for Q8K394

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3408105417 24 K>N No EVA
rs3407149002 24 K>Q No EVA
rs3407938596 27 L>Q No EVA
rs3407853905 28 K>G No EVA
rs3389481081 102 L>M No EVA
rs3389477775 205 R>H No EVA
rs3406774915 272 W>S No EVA
rs6210087 273 I>V No EVA
rs3407696359 276 M>T No EVA
rs3406774937 360 D>G No EVA
rs3407759783 361 T>I No EVA
rs3407715667 364 L>F No EVA
rs3389471279 421 E>D No EVA
rs3408106820 475 V>M No EVA
rs3407715694 486 Y>* No EVA
rs3389464990 531 V>M No EVA
rs3389448531 555 Y>* No EVA
rs3389419248 593 M>K No EVA
rs3389471270 594 S>Y No EVA
rs226238704 629 V>I No EVA
rs3389465054 630 Q>K No EVA
rs3389438711 657 Y>* No EVA
rs3389463897 668 Y>H No EVA
rs3389438762 671 R>H No EVA
rs3389469103 681 M>T No EVA
rs3389419223 684 D>E No EVA
rs3389462526 691 Q>H No EVA
rs3389464998 728 V>A No EVA
rs3389471285 737 E>V No EVA
rs3389465032 763 S>R No EVA
rs3389448551 777 G>D No EVA
rs3389471158 797 E>K No EVA
rs3389465045 810 P>T No EVA
rs3389482411 833 L>Q No EVA
rs3389471340 844 G>S No EVA
rs3389438741 850 F>L No EVA
rs3389382534 854 Q>* No EVA
rs3389448559 856 G>D No EVA
rs3389482402 863 Q>H No EVA
rs3407761406 865 L>R No EVA
rs3408106792 865 L>V No EVA
rs3406850059 867 G>A No EVA
rs3389462546 884 R>W No EVA
rs3406774914 887 G>* No EVA
rs3389438771 925 Q>* No EVA
rs3389473408 928 I>V No EVA
rs3389469082 987 T>I No EVA
rs3389477739 998 L>P No EVA
rs3389448582 1007 M>I No EVA
rs3389473482 1020 D>Y No EVA
rs3389487284 1025 K>M No EVA
rs3389462543 1028 H>Y No EVA
rs3389482346 1051 E>G No EVA
rs3407939953 1078 A>S No EVA
rs3407609451 1079 K>* No EVA
rs3389419176 1079 K>N No EVA
rs3407697149 1080 N>H No EVA
rs3389448595 1083 L>M No EVA

No associated diseases with Q8K394

6 regional properties for Q8K394

Type Name Position InterPro Accession
domain C2 domain 735 - 864 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 427 - 572 IPR000909
domain Phospholipase C, phosphatidylinositol-specific, Y domain 619 - 735 IPR001711
domain Pleckstrin homology domain 138 - 254 IPR001849
domain Phosphoinositide-specific phospholipase C, EF-hand-like domain 337 - 420 IPR015359
domain Inactive phospholipase C-like protein 2, EF-hand domain 272 - 415 IPR028382

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GABA receptor binding Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate.
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

9 GO annotations of biological process

Name Definition
B cell proliferation involved in immune response The expansion of a B cell population by cell division following B cell activation during an immune response.
B-1a B cell differentiation The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
gamma-aminobutyric acid signaling pathway The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
negative regulation of B cell receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
negative regulation of cold-induced thermogenesis Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
positive regulation of receptor binding Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.
regulation of synaptic transmission, GABAergic Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).

29 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAECGRGAAG GALPTSPSPA LGAKGALKAG AGEGGGGGGG GRLGHGRARY DSGGVSNGDC
70 80 90 100 110 120
SLGVSGDEAR TSPGRGPLGV ALARTPSPAA GPVPRDSKPG GLPRRSSIIK DGTKQKRERK
130 140 150 160 170 180
KTVSFSSMPT EKKISSASDC INSMVEGSEL KKVRSNSRIY HRYFLLDADM QSLRWEPSKK
190 200 210 220 230 240
DSEKAKIDIK SIKEVRTGKN TDIFRSNGIS EQISEDCAFS VIYGENYESL DLVANSADVA
250 260 270 280 290 300
NIWVTGLRYL ISYGKHTLDM LESSQDNMRT SWISQMFSEI DVDGLGHITL CHAVQCIRNL
310 320 330 340 350 360
NPGLKTSKIE LKFKELHKSK DKAGTEITKE EFIEVFHELC TRPEIYFLLV QFSSNKEFLD
370 380 390 400 410 420
TKDLMMFLEA EQGVAHINEE ISLEIIHKYE PSKEGQEKGW LSIDGFTNYL MSPDCYIFDP
430 440 450 460 470 480
EHKKVCQDMK QPLSHYFINS SHNTYLIEDQ FRGPSDITGY IRALKMGCRS VELDVWDGPD
490 500 510 520 530 540
NEPVIYTGHT MTSQIVFRSV IDIINKYAFF ASEYPLILCL ENHCSIKQQK VMVQHMKKIL
550 560 570 580 590 600
GDKLYTTSPN MEESYLPSPD VLKGKILIKA KKLSSNCSGV EGDVTDEDEG AEMSQRMGKE
610 620 630 640 650 660
NVEQPNHVPV KRFQLCKELS ELVSICKSVQ FKEFQVSFQV QKYWEVCSFN EVLASKYANE
670 680 690 700 710 720
NPGDFVNYNK RFLARVFPSP MRIDSSNMNP QDFWKCGCQI VAMNFQTPGL MMDLNVGWFR
730 740 750 760 770 780
QNGNCGYVLR PAIMREEVSF FSANTKDSVP GVSPQLLHIK IISGQNFPKP KGSGAKGDVV
790 800 810 820 830 840
DPYVYVEIHG IPADCAEQRT KTVNQNGDAP IFDESFEFQI NLPELAMVRF VVLDDDYIGD
850 860 870 880 890 900
EFIGQYTIPF ECLQTGYRHV PLQSLTGEVL AHASLFVHVA ITNRRGGGKP HKRGLSVRKG
910 920 930 940 950 960
KKSREYASLR TLWIKTVDEV FKNAQPPIRD ATDLRENMQN AVVSFKELCG LSSVANLMQC
970 980 990 1000 1010 1020
MLAVSPRFLG PDNNPLVVLN LSEPYPTMEL QAIVPEVLKK IVTTYDMMMQ SLKALIENAD
1030 1040 1050 1060 1070 1080
AVYEKIVHCQ KAAMEFHEHL HSIGTKEGLK ERKLQKAVES FTWNITILKG QADLLKYAKN
1090 1100 1110 1120
ETLENLKQIH FAAVSCGLNK PGTENSEAQK PRRSLEAIPE KASDENGD