A5D6R3
PR
Gene name |
plcd3a (zgc:158396) |
Protein name |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A |
Names |
Phosphoinositide phospholipase C-delta-3-A, Phospholipase C-delta-3-A, PLC-delta-3-A |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:569040 |
EC number |
3.1.4.11: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5D6R3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5D6R3-F1 | Predicted | AlphaFoldDB |
No variants for A5D6R3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5D6R3 | |||||
No associated diseases with A5D6R3
9 regional properties for A5D6R3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 621 - 750 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 313 - 459 | IPR000909 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 506 - 621 | IPR001711 |
| domain | Pleckstrin homology domain | 38 - 151 | IPR001849 |
| domain | EF-hand domain | 159 - 194 | IPR002048-1 |
| domain | EF-hand domain | 195 - 230 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 172 - 184 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 208 - 220 | IPR018247-2 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain | 163 - 300 | IPR039504 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.11 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cleavage furrow | The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32383 | PLC1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q1RML2 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Bos taurus (Bovine) | PR |
| P10895 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Bos taurus (Bovine) | SS |
| Q2VRL0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Gallus gallus (Chicken) | PR |
| Q86YW0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Homo sapiens (Human) | PR |
| Q9P212 | PLCE1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Homo sapiens (Human) | SS |
| Q9BRC7 | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | Homo sapiens (Human) | SS |
| Q15111 | PLCL1 | Inactive phospholipase C-like protein 1 | Homo sapiens (Human) | PR |
| P51178 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Homo sapiens (Human) | EV |
| Q9UPR0 | PLCL2 | Inactive phospholipase C-like protein 2 | Homo sapiens (Human) | PR |
| Q8N3E9 | PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Homo sapiens (Human) | SS |
| Q8R3B1 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Mus musculus (Mouse) | SS |
| Q8K394 | Plcl2 | Inactive phospholipase C-like protein 2 | Mus musculus (Mouse) | PR |
| Q8K4S1 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Mus musculus (Mouse) | SS |
| Q8K2J0 | Plcd3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Mus musculus (Mouse) | PR |
| Q7YRU3 | PLCZ | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Sus scrofa (Pig) | PR |
| P10688 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Rattus norvegicus (Rat) | SS |
| Q99P84 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Rattus norvegicus (Rat) | EV |
| Q39032 | PLC1 | Phosphoinositide phospholipase C 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56W08 | PLC3 | Phosphoinositide phospholipase C 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NMA7 | PLC9 | Phosphoinositide phospholipase C 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GV43 | PLC6 | Phosphoinositide phospholipase C 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C2 | PLC5 | Phosphoinositide phospholipase C 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STZ3 | PLC8 | Phosphoinositide phospholipase C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C1 | PLC4 | Phosphoinositide phospholipase C 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLGRKKNPET | VQTESKSVES | KTHDPLRRLG | VLDDEDVLLM | LQGSKMMKVR | SQRWRKDRRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLLEDCVTVW | CESSKTSRKS | NRQQTFSVTE | VECVREGCQS | ECLRRMTDLV | PEKNCFTVVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGGRKSLDLC | CHTQEEAERW | VRGIRTLKDR | VSNMSQKEKL | DHWIRGYLRR | ADQNQDGKMS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YDEVKHLLQL | INIDLNEQYA | RTLFKKCDRS | CDGRLDHVEI | EEFCREMMRR | PELDAVFRHY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGNGCVLTTL | ELRDFLGDQG | EDASLVHAKS | LIQTFELNDW | AQKNLFMTQN | GFTMYMLSKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NDVFNPDHTH | VYQDMSKPLA | HYYISSSHNT | YLTKDQVTSA | SSTEPYIRAL | NQGCRCVELD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CWDGDKGEPI | IYHGHTLTSK | VLFKEVIETI | AQYAFKASPY | PLILSLENHC | SVEQQAIMAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLQSILGKKL | LAKPLSDLPL | KQLPSPEELK | GRILLKGKKL | NGLLGKTESW | TSFTNSSDEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SVAGGNKKES | KKDLARSAST | KLSPELSDLV | VYCQSVPFSG | FETANQRPPS | VITSFSENEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKLIKDSGKL | FVRNNSRQLS | RIYPSAQRLQ | SSNFDPQDMW | NAGCQMVALN | FQTPGEQMDL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NQGRFLPNGR | CGYVLKPEFL | CDPKSDFDPE | NTGGGPGHIP | TQLTIRVISA | QQLPKINTDK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PNSIVDPQVW | VEIHGVSIDK | ARAKTQRIDN | NGFNPRWDCT | VSFQLQLPEL | ALVRFMVEDH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DHKSKNDFIG | QFTLPFTSLR | TGYRHVHLLK | ADGSTLSPAT | LFIHVKVVRR | GVHIKTVSER |
| IGKA |