Q944C2

PR
Gene name
PLC5 (ATHATPLC6, At5g58690, MZN1.13, MZN1.15)
Protein name
Phosphoinositide phospholipase C 5
Names
Phosphoinositide phospholipase PLC5, AtPLC5, AtPLCx, PI-PLC5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G58690
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

214-337 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q944C2

Entry ID Method Resolution Chain Position Source
AF-Q944C2-F1 Predicted AlphaFoldDB

41 variants for Q944C2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_23712026_T_G 2 K>T No 1000Genomes
ENSVATH03449063 11 G>V No 1000Genomes
ENSVATH00741279 32 A>T No 1000Genomes
ENSVATH12845435 60 E>A No 1000Genomes
tmp_5_23711853_C_T 60 E>K No 1000Genomes
ENSVATH12845424 69 I>N No 1000Genomes
tmp_5_23711823_T_C 70 I>V No 1000Genomes
tmp_5_23711799_G_T 78 H>N No 1000Genomes
tmp_5_23711779_C_G 84 L>F No 1000Genomes
ENSVATH12845423 86 H>Y No 1000Genomes
tmp_5_23711771_G_C 87 T>R No 1000Genomes
ENSVATH12845422 103 N>S No 1000Genomes
ENSVATH03449060 123 I>V No 1000Genomes
ENSVATH12845416 153 V>I No 1000Genomes
ENSVATH07446317 168 D>N No 1000Genomes
ENSVATH12845401 236 G>S No 1000Genomes
ENSVATH07446313 249 Y>D No 1000Genomes
tmp_5_23710971_T_G 266 K>T No 1000Genomes
tmp_5_23710795_T_C 297 E>G No 1000Genomes
tmp_5_23710786_C_T 300 G>E No 1000Genomes
tmp_5_23710680_A_T 335 D>E No 1000Genomes
tmp_5_23710620_C_A 355 M>I No 1000Genomes
tmp_5_23710283_C_G 409 M>I No 1000Genomes
tmp_5_23710252_A_G 420 C>R No 1000Genomes
ENSVATH03449055 426 P>Q No 1000Genomes
tmp_5_23710231_C_T 427 D>N No 1000Genomes
tmp_5_23710226_A_C 428 F>L No 1000Genomes
ENSVATH03449054 429 M>I No 1000Genomes
tmp_5_23710195_A_C 439 F>V No 1000Genomes
ENSVATH03449053 447 I>K No 1000Genomes
ENSVATH03449052 448 K>E No 1000Genomes
tmp_5_23710087_A_G 475 S>P No 1000Genomes
ENSVATH07446304 485 T>A No 1000Genomes
ENSVATH07446303 492 V>I No 1000Genomes
ENSVATH07446302 498 K>T No 1000Genomes
ENSVATH14639677 518 P>T No 1000Genomes
ENSVATH14639676 541 Q>H No 1000Genomes
ENSVATH00741274 564 E>K No 1000Genomes
tmp_5_23709704_G_A 570 T>I No 1000Genomes
tmp_5_23709699_G_A 572 L>F No 1000Genomes
tmp_5_23709694_C_A 573 M>I No 1000Genomes

No associated diseases with Q944C2

17 regional properties for Q944C2

Type Name Position InterPro Accession
domain FERM domain 26 - 431 IPR000299
domain Protein kinase domain 589 - 875 IPR000719-1
domain Protein kinase domain 897 - 1176 IPR000719-2
domain SH2 domain 452 - 539 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 590 - 866 IPR001245-1
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 898 - 1167 IPR001245-2
active_site Tyrosine-protein kinase, active site 1019 - 1031 IPR008266
domain Tyrosine-protein kinase, non-receptor, TYK2, N-terminal 169 - 182 IPR016045-1
domain Tyrosine-protein kinase, non-receptor, TYK2, N-terminal 266 - 276 IPR016045-2
domain Tyrosine-protein kinase, non-receptor, TYK2, N-terminal 516 - 526 IPR016045-3
binding_site Protein kinase, ATP binding site 903 - 930 IPR017441
domain Band 4.1 domain 22 - 275 IPR019749
domain Tyrosine-protein kinase, catalytic domain 589 - 866 IPR020635-1
domain Tyrosine-protein kinase, catalytic domain 897 - 1169 IPR020635-2
domain JAK, FERM F2 lobe domain 142 - 266 IPR041046
domain FERM F1 lobe ubiquitin-like domain 28 - 124 IPR041155
domain JAK1-3/TYK2, pleckstrin homology-like domain 285 - 432 IPR041381

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Cytoplasm, cytosol
  • Cell membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

43 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q00722 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Homo sapiens (Human) EV
Q01970 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Homo sapiens (Human) EV
Q9NQ66 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Homo sapiens (Human) EV
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q15147 PLCB4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10686 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Rattus norvegicus (Rat) EV
P24135 Plcg2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Rattus norvegicus (Rat) SS
O89040 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Rattus norvegicus (Rat) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
P10687 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q99JE6 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Rattus norvegicus (Rat) SS
G5EBH0 egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Caenorhabditis elegans SS
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKRDMGSYKM GLCCSDKLRM NRGAPPQDVV TAFVEYTEGR SHMTAEQLCR FLVEVQDETE
70 80 90 100 110 120
VLVSDAEKII ERITCERHHI TKFLRHTLNL DDFFSFLFSD DLNHPIDSKV HQDMASPLSH
130 140 150 160 170 180
YFIYTSHNSY LTGNQINSEC SDVPLIKALK RGVRALELDM WPNSTKDDIL VLHGWAWTPP
190 200 210 220 230 240
VELVKCLRSI KEHAFYASAY PVILTLEDHL TPDLQAKAAE MMKEIFMDMV YFPEAGGLKE
250 260 270 280 290 300
FPSPEDLKYK IVISTKPPKG SLRKDKDSES DASGKASSDV SADDEKTEEE TSEAKNEEDG
310 320 330 340 350 360
FDQESSNLDF LTYSRLITIP SGNAKNGLKE ALTIDNGGVR RLSLREQKFK KATEMYGTEV
370 380 390 400 410 420
IKFTQKNLLR IYPKATRVNS SNYRPYNGWM YGAQMVAFNM QGYGRALWMM HGMFRGNGGC
430 440 450 460 470 480
GYVKKPDFMM NNNLSGEVFN PKAKLPIKKT LKVKVYMGKG WDSGFQRTCF NTWSSPNFYT
490 500 510 520 530 540
RVGITGVRGD KVMKKTKKEQ KTWEPFWNEE FEFQLTVPEL ALLRIEVHDY NMPEKDDFSG
550 560 570
QTCLPVSELR QGIRSVPLYD RKGERLVSVT LLMRFHFL