Q8GV43

PR
Gene name
PLC6 (PLC8, At2g40116, F27I1)
Protein name
Phosphoinositide phospholipase C 6
Names
Phosphoinositide phospholipase PLC6, AtPLC6, AtPLC8, PI-PLC6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G40116
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GV43

Entry ID Method Resolution Chain Position Source
AF-Q8GV43-F1 Predicted AlphaFoldDB

42 variants for Q8GV43

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05688817 37 T>A No 1000Genomes
ENSVATH05688818 47 F>L No 1000Genomes
ENSVATH05688819 48 A>S No 1000Genomes
tmp_2_16751924_C_T 48 A>V No 1000Genomes
ENSVATH01971773 50 G>C No 1000Genomes
tmp_2_16751932_G_T 51 G>C No 1000Genomes
tmp_2_16751933_G_T 51 G>V No 1000Genomes
tmp_2_16751942_G_T 54 G>V No 1000Genomes
ENSVATH05688823 77 S>F No 1000Genomes
ENSVATH05688823 77 S>Y No 1000Genomes
tmp_2_16752022_G_A 81 D>N No 1000Genomes
tmp_2_16752073_G_T 98 V>F No 1000Genomes
tmp_2_16752076_A_G 99 I>V No 1000Genomes
tmp_2_16752127_G_A 116 D>N No 1000Genomes
tmp_2_16752275_T_C 139 M>T No 1000Genomes
tmp_2_16752287_T_A 143 L>* No 1000Genomes
tmp_2_16752364_C_A 169 P>T No 1000Genomes
ENSVATH14600809 170 V>A No 1000Genomes
ENSVATH13592258 221 S>F No 1000Genomes
ENSVATH01971786 244 A>S No 1000Genomes
tmp_2_16752765_G_A 246 M>I No 1000Genomes
ENSVATH00266952 264 L>V No 1000Genomes
ENSVATH01971793 294 V>I No 1000Genomes
ENSVATH05688836 299 N>S No 1000Genomes
ENSVATH05688837 321 M>I No 1000Genomes
ENSVATH13592259 329 S>N No 1000Genomes
tmp_2_16753300_A_G 397 R>G No 1000Genomes
ENSVATH05688841 401 R>Q No 1000Genomes
ENSVATH01971802 406 I>V No 1000Genomes
ENSVATH05688842 418 Y>C No 1000Genomes
tmp_2_16753456_G_C 423 G>A No 1000Genomes
tmp_2_16753632_C_G 446 H>D No 1000Genomes
tmp_2_16753689_A_T 465 M>L No 1000Genomes
ENSVATH14600812 519 I>V No 1000Genomes
ENSVATH05688850 527 A>V No 1000Genomes
tmp_2_16754168_A_T 567 M>L No 1000Genomes
tmp_2_16754208_C_G 580 P>R No 1000Genomes
tmp_2_16754238_C_G 590 S>C No 1000Genomes
ENSVATH14600813 599 E>K No 1000Genomes
ENSVATH14600814 605 R>L No 1000Genomes
tmp_2_16754294_C_T 609 R>C No 1000Genomes
tmp_2_16754300_A_T 611 I>F No 1000Genomes

No associated diseases with Q8GV43

5 regional properties for Q8GV43

Type Name Position InterPro Accession
domain Protein kinase domain 89 - 382 IPR000719
domain AGC-kinase, C-terminal 383 - 455 IPR000961
active_site Serine/threonine-protein kinase, active site 208 - 220 IPR008271
binding_site Protein kinase, ATP binding site 95 - 118 IPR017441
domain Protein kinase, C-terminal 401 - 445 IPR017892

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

43 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q00722 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Homo sapiens (Human) EV
Q01970 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Homo sapiens (Human) EV
Q9NQ66 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Homo sapiens (Human) EV
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q15147 PLCB4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10686 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Rattus norvegicus (Rat) EV
P24135 Plcg2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Rattus norvegicus (Rat) SS
O89040 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Rattus norvegicus (Rat) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
P10687 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q99JE6 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Rattus norvegicus (Rat) SS
G5EBH0 egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Caenorhabditis elegans SS
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGKEKKTESY NNDSGSYNYR MFKFYNRKFK INEVTPTDDV RDAFCQFAVG GGGGGTDGDS
70 80 90 100 110 120
SDGDGSTGVM GAEQLCSFLD DHGESTTVAE AQRLIDEVIR RRHHVTRFTR HGLDLDDFFN
130 140 150 160 170 180
FLFYDDLNPP ITPHVHQDMT APLSHYFIYT GHNSYLTGNQ LSSDCSEVPV IKALQRGVRV
190 200 210 220 230 240
IELDLWPNST GTDINVLHGR TLTTPVPLMK CLKSIRDYAF SSSPYPVIIT LEDHLTPDLQ
250 260 270 280 290 300
AKVAEMATQI FGQMLYYPES DSLLEFPSPA SLLHRIIIST KPPKEYLESR NPIVKQKDNN
310 320 330 340 350 360
VSPSSEDETP RTEEIQTLES MLFDQDFESK SDSDQEDEEA SEDQKPAYKR LITIHAGKPK
370 380 390 400 410 420
GTVKEEMKVV VDKVRRLSLS EQELDRTCSS NSQDVVRFTQ RNLLRIYPKG TRFNSSNYKP
430 440 450 460 470 480
LIGWTHGAQM IAFNMQGYGK SLWLMHGMFR ANGGCGYVKK PNFLMKKGFH DEVFDPRKKL
490 500 510 520 530 540
PVKETLKVKV YMGDGWRMDF SHTHFDAYSP PDFYTKMFIV GVPADNAKKK TKIIEDNWYP
550 560 570 580 590 600
IWDEEFSFPL TVPELALLRI EVREYDMSEK DDFGGQTCLP VAELRPGIRS VPLYDKKGEK
610
MKSVRLLMRF IFE