P10895
SS
Gene name |
PLCD1 |
Protein name |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
Names |
EC 3.1.4.11 , Phosphoinositide phospholipase C-delta-1 , Phospholipase C-III , PLC-III , Phospholipase C-delta-1 , PLC-delta-1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281986 |
EC number |
3.1.4.11: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
PLCD1 functions the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Autoinhibitory region is a portion of the linker that separates the conserved X and Y boxes comprising the catalytic TIM barrel. The disordered X/Y linker is capable of autoinhibition by hindering productive binding of PLC-δ1 to membranes and thereby restricting access of PtdIns(4,5)P2 to the active site. The active site of a PLC isozyme toward phospholipid membranes should force the negatively charged X/Y linker away from the active site, therein relieving autoinhibition of the enzyme.
Autoinhibitory domains (AIDs)
Target domain |
316-656 (TIM barrel) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P10895
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P10895-F1 | Predicted | AlphaFoldDB |
221 variants for P10895
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs136710073 | 10 | L>R | No | EVA | |
| rs441090208 | 35 | S>P | No | EVA | |
| rs470952013 | 45 | Q>K | No | EVA | |
| rs457766263 | 67 | F>L | No | EVA | |
| rs439393451 | 70 | E>D | No | EVA | |
| rs475480498 | 71 | D>V | No | EVA | |
| rs457189055 | 72 | I>L | No | EVA | |
| rs441967309 | 75 | V>G | No | EVA | |
| rs475005205 | 77 | M>L | No | EVA | |
| rs453322086 | 77 | M>T | No | EVA | |
| rs434855963 | 83 | G>V | No | EVA | |
| rs477847656 | 87 | F>S | No | EVA | |
| rs462684189 | 89 | R>L | No | EVA | |
| rs437406666 | 90 | D>A | No | EVA | |
| rs437406666 | 90 | D>G | No | EVA | |
| rs452699525 | 90 | D>N | No | EVA | |
| rs470458614 | 91 | V>A | No | EVA | |
| rs448682841 | 93 | E>G | No | EVA | |
| rs468139775 | 95 | R>P | No | EVA | |
| rs446471299 | 97 | F>S | No | EVA | |
| rs479293757 | 98 | S>P | No | EVA | |
| rs439330060 | 101 | F>L | No | EVA | |
| rs457701254 | 101 | F>S | No | EVA | |
| rs463619133 | 103 | D>A | No | EVA | |
| rs481834892 | 103 | D>H | No | EVA | |
| rs474961574 | 105 | R>H | No | EVA | |
| rs441263017 | 107 | T>P | No | EVA | |
| rs471048077 | 108 | L>Q | No | EVA | |
| rs452636018 | 109 | D>A | No | EVA | |
| rs437343579 | 111 | I>L | No | EVA | |
| rs476836001 | 112 | A>S | No | EVA | |
| rs436667104 | 118 | A>D | No | EVA | |
| rs480091644 | 121 | W>S | No | EVA | |
| rs466514438 | 124 | G>A | No | EVA | |
| rs446374299 | 132 | S>T | No | EVA | |
| rs434364736 | 133 | G>R | No | EVA | |
| rs464052549 | 140 | K>T | No | EVA | |
| rs134947661 | 173 | N>T | No | EVA | |
| rs447636431 | 228 | L>V | No | EVA | |
| rs478885183 | 234 | V>G | No | EVA | |
| rs460491862 | 249 | A>S | No | EVA | |
| rs445359980 | 257 | R>L | No | EVA | |
| rs463158781 | 260 | P>L | No | EVA | |
| rs444715245 | 262 | E>* | No | EVA | |
| rs474543569 | 264 | A>P | No | EVA | |
| rs446356857 | 270 | M>R | No | EVA | |
| rs437534328 | 271 | T>N | No | EVA | |
| rs468933721 | 273 | D>G | No | EVA | |
| rs450488490 | 278 | Y>S | No | EVA | |
| rs480343934 | 279 | L>R | No | EVA | |
| rs461692063 | 280 | L>P | No | EVA | |
| rs461692063 | 280 | L>R | No | EVA | |
| rs479418765 | 281 | S>A | No | EVA | |
| rs479418765 | 281 | S>P | No | EVA | |
| rs457829663 | 282 | A>G | No | EVA | |
| rs475786247 | 283 | D>A | No | EVA | |
| rs463698367 | 283 | D>E | No | EVA | |
| rs442030575 | 285 | S>T | No | EVA | |
| rs453431749 | 286 | A>D | No | EVA | |
| rs475058782 | 286 | A>P | No | EVA | |
| rs434921149 | 287 | F>C | No | EVA | |
| rs471179845 | 288 | D>A | No | EVA | |
| rs452709042 | 289 | L>R | No | EVA | |
| rs470526569 | 291 | H>P | No | EVA | |
| rs468060676 | 294 | V>A | No | EVA | |
| rs435166793 | 294 | V>F | No | EVA | |
| rs446499672 | 295 | Y>C | No | EVA | |
| rs446499672 | 295 | Y>S | No | EVA | |
| rs479357353 | 296 | Q>K | No | EVA | |
| rs457764414 | 297 | D>A | No | EVA | |
| rs457764414 | 297 | D>G | No | EVA | |
| rs482150652 | 298 | M>R | No | EVA | |
| rs482150652 | 298 | M>T | No | EVA | |
| rs445850918 | 298 | M>V | No | EVA | |
| rs384390208 | 299 | D>A | No | EVA | |
| rs384390208 | 299 | D>G | No | EVA | |
| rs463684203 | 299 | D>H | No | EVA | |
| rs384390208 | 299 | D>V | No | EVA | |
| rs474997143 | 305 | Y>C | No | EVA | |
| rs474997143 | 305 | Y>F | No | EVA | |
| rs474997143 | 305 | Y>S | No | EVA | |
| rs459779023 | 314 | Y>S | No | EVA | |
| rs441323753 | 316 | L>R | No | EVA | |
| rs471114356 | 323 | P>H | No | EVA | |
| rs443831773 | 326 | T>K | No | EVA | |
| rs476895483 | 330 | I>S | No | EVA | |
| rs469983450 | 334 | C>W | No | EVA | |
| rs448317720 | 337 | C>G | No | EVA | |
| rs466077491 | 348 | P>T | No | EVA | |
| rs477441301 | 362 | S>P | No | EVA | |
| rs458932315 | 372 | A>D | No | EVA | |
| rs436183610 | 383 | Y>S | No | EVA | |
| rs447581906 | 385 | V>A | No | EVA | |
| rs447581906 | 385 | V>D | No | EVA | |
| rs466016967 | 385 | V>F | No | EVA | |
| rs465359255 | 386 | I>N | No | EVA | |
| rs432315589 | 386 | I>V | No | EVA | |
| rs483137721 | 392 | H>P | No | EVA | |
| rs461297298 | 395 | L>P | No | EVA | |
| rs460620305 | 404 | H>P | No | EVA | |
| rs439070210 | 405 | L>Q | No | EVA | |
| rs472102461 | 406 | R>H | No | EVA | |
| rs458522205 | 407 | T>P | No | EVA | |
| rs443210577 | 408 | L>R | No | EVA | |
| rs476304219 | 410 | G>V | No | EVA | |
| rs436121815 | 412 | M>R | No | EVA | |
| rs453962392 | 415 | D>A | No | EVA | |
| rs432236507 | 417 | P>Q | No | EVA | |
| rs432236507 | 417 | P>R | No | EVA | |
| rs465247530 | 418 | L>* | No | EVA | |
| rs450033976 | 419 | D>N | No | EVA | |
| rs437995912 | 419 | D>V | No | EVA | |
| rs478946520 | 422 | V>G | No | EVA | |
| rs449285899 | 422 | V>I | No | EVA | |
| rs460557046 | 423 | T>P | No | EVA | |
| rs445412912 | 424 | S>T | No | EVA | |
| rs478516119 | 426 | P>R | No | EVA | |
| rs463222009 | 427 | S>P | No | EVA | |
| rs460212925 | 430 | Q>E | No | EVA | |
| rs438538910 | 431 | L>M | No | EVA | |
| rs456356203 | 432 | R>W | No | EVA | |
| rs444275241 | 434 | K>E | No | EVA | |
| rs473925769 | 437 | L>Q | No | EVA | |
| rs455539208 | 440 | K>R | No | EVA | |
| rs466854474 | 444 | G>V | No | EVA | |
| rs469544347 | 445 | L>H | No | EVA | |
| rs433308748 | 445 | L>I | No | EVA | |
| rs480889359 | 446 | F>L | No | EVA | |
| rs478608434 | 451 | E>G | No | EVA | |
| rs460200344 | 452 | G>S | No | EVA | |
| rs477971049 | 453 | G>D | No | EVA | |
| rs462695411 | 458 | V>A | No | EVA | |
| rs444213715 | 459 | V>G | No | EVA | |
| rs473862692 | 460 | S>* | No | EVA | |
| rs461878123 | 461 | D>E | No | EVA | |
| rs440307720 | 465 | A>G | No | EVA | |
| rs473376466 | 466 | A>V | No | EVA | |
| rs433252421 | 469 | E>Q | No | EVA | |
| rs457497214 | 470 | D>E | No | EVA | |
| rs475974621 | 470 | D>G | No | EVA | |
| rs435789054 | 471 | E>K | No | EVA | |
| rs468823850 | 472 | A>G | No | EVA | |
| rs468823850 | 472 | A>V | No | EVA | |
| rs435119431 | 473 | V>G | No | EVA | |
| rs447171739 | 473 | V>L | No | EVA | |
| rs466511685 | 475 | S>N | No | EVA | |
| rs444849375 | 475 | S>R | No | EVA | |
| rs462659694 | 478 | Q>H | No | EVA | |
| rs450548335 | 479 | H>D | No | EVA | |
| rs480214240 | 479 | H>P | No | EVA | |
| rs440246240 | 481 | S>Y | No | EVA | |
| rs473359261 | 482 | K>R | No | EVA | |
| rs447737933 | 483 | E>G | No | EVA | |
| rs459116919 | 484 | D>G | No | EVA | |
| rs477581868 | 484 | D>Y | No | EVA | |
| rs443810576 | 485 | K>E | No | EVA | |
| rs476669088 | 486 | L>P | No | EVA | |
| rs461483229 | 487 | R>S | No | EVA | |
| rs443131213 | 491 | E>D | No | EVA | |
| rs452867078 | 495 | M>R | No | EVA | |
| rs434455401 | 496 | V>A | No | EVA | |
| rs470694900 | 498 | Y>C | No | EVA | |
| rs470020810 | 503 | H>Q | No | EVA | |
| rs448378663 | 504 | F>L | No | EVA | |
| rs477502715 | 512 | T>A | No | EVA | |
| rs458993714 | 512 | T>S | No | EVA | |
| rs483024650 | 516 | A>G | No | EVA | |
| rs443070344 | 518 | Y>C | No | EVA | |
| rs479245891 | 538 | S>R | No | EVA | |
| rs449357005 | 538 | S>T | No | EVA | |
| rs467229473 | 540 | V>A | No | EVA | |
| rs445472101 | 543 | N>H | No | EVA | |
| rs478579584 | 543 | N>K | No | EVA | |
| rs458499373 | 544 | V>A | No | EVA | |
| rs443259055 | 545 | N>Y | No | EVA | |
| rs482673563 | 546 | H>D | No | EVA | |
| rs443359522 | 548 | S>I | No | EVA | |
| rs442560966 | 551 | Y>S | No | EVA | |
| rs472371855 | 552 | P>A | No | EVA | |
| rs453934800 | 555 | W>C | No | EVA | |
| rs438667756 | 559 | S>A | No | EVA | |
| rs471733332 | 561 | N>K | No | EVA | |
| rs456344173 | 562 | Y>S | No | EVA | |
| rs437969351 | 566 | E>G | No | EVA | |
| rs474049094 | 569 | N>T | No | EVA | |
| rs455663668 | 572 | C>F | No | EVA | |
| rs432810215 | 576 | A>P | No | EVA | |
| rs450550318 | 577 | L>R | No | EVA | |
| rs480216449 | 578 | N>K | No | EVA | |
| rs468385222 | 579 | F>L | No | EVA | |
| rs446719139 | 581 | T>P | No | EVA | |
| rs458117344 | 582 | P>R | No | EVA | |
| rs446078786 | 601 | Y>D | No | EVA | |
| rs482278442 | 608 | L>R | No | EVA | |
| rs517434003 | 619 | A>V | No | EVA | |
| rs463858520 | 626 | W>R | No | EVA | |
| rs1114322357 | 665 | R>Q | No | EVA | |
| rs475253184 | 682 | P>R | No | EVA | |
| rs435313050 | 695 | P>T | No | EVA | |
| rs454732613 | 729 | G>A | No | EVA | |
| rs436325918 | 730 | Y>S | No | EVA | |
| rs454124446 | 732 | H>P | No | EVA | |
| rs432416984 | 733 | I>S | No | EVA | |
| rs465309141 | 734 | H>P | No | EVA | |
| rs450150215 | 735 | L>P | No | EVA | |
| rs438157751 | 736 | L>R | No | EVA | |
| rs468036947 | 739 | N>T | No | EVA | |
| rs479390523 | 741 | D>A | No | EVA | |
| rs449488035 | 741 | D>N | No | EVA | |
| rs459242387 | 742 | Q>P | No | EVA | |
| rs447286840 | 743 | H>R | No | EVA | |
| rs477050840 | 745 | S>P | No | EVA | |
| rs458625083 | 746 | A>T | No | EVA | |
| rs443384017 | 747 | T>P | No | EVA | |
| rs461178649 | 748 | L>P | No | EVA | |
| rs442664933 | 749 | F>C | No | EVA | |
| rs442664933 | 749 | F>S | No | EVA | |
| rs472550754 | 752 | V>G | No | EVA | |
| rs454004387 | 754 | L>I | No | EVA | |
| rs432355557 | 756 | D>Y | No | EVA | |
| rs471656888 | 757 | D>Y | No | EVA |
No associated diseases with P10895
1 regional properties for P10895
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Apoptosis regulator, Bcl-2, BH3 motif, conserved site | 86 - 100 | IPR020728 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.11 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidylinositol metabolic process | The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| release of sequestered calcium ion into cytosol | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32383 | PLC1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q1RML2 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Bos taurus (Bovine) | PR |
| P10894 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | Bos taurus (Bovine) | SS |
| P08487 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Bos taurus (Bovine) | EV SS |
| Q2VRL0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Gallus gallus (Chicken) | PR |
| Q86YW0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Homo sapiens (Human) | PR |
| Q9P212 | PLCE1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Homo sapiens (Human) | SS |
| Q9BRC7 | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | Homo sapiens (Human) | SS |
| Q15111 | PLCL1 | Inactive phospholipase C-like protein 1 | Homo sapiens (Human) | PR |
| Q9UPR0 | PLCL2 | Inactive phospholipase C-like protein 2 | Homo sapiens (Human) | PR |
| Q8N3E9 | PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Homo sapiens (Human) | SS |
| P51178 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Homo sapiens (Human) | EV |
| Q8K394 | Plcl2 | Inactive phospholipase C-like protein 2 | Mus musculus (Mouse) | PR |
| Q8K2J0 | Plcd3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Mus musculus (Mouse) | PR |
| Q8K4S1 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Mus musculus (Mouse) | SS |
| Q8R3B1 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Mus musculus (Mouse) | SS |
| Q7YRU3 | PLCZ | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Sus scrofa (Pig) | PR |
| Q99P84 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Rattus norvegicus (Rat) | EV |
| P10688 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Rattus norvegicus (Rat) | SS |
| Q39032 | PLC1 | Phosphoinositide phospholipase C 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56W08 | PLC3 | Phosphoinositide phospholipase C 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NMA7 | PLC9 | Phosphoinositide phospholipase C 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GV43 | PLC6 | Phosphoinositide phospholipase C 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C2 | PLC5 | Phosphoinositide phospholipase C 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STZ3 | PLC8 | Phosphoinositide phospholipase C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C1 | PLC4 | Phosphoinositide phospholipase C 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A5D6R3 | plcd3a | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSGRDFLTL | HGLQDDKDLQ | ALLKGGQLLK | VKSNSWRRER | FYKLQEDCKT | IWQESRKVMR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPESQLFSIE | DIQEVRMGHR | TEGLEKFARD | VPENRCFSIV | FKDQRNTLDL | IAPSPADAQH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WVQGLGKIIH | HSGSMDQQQK | LRHWIHSCLR | KADKNKDNKM | SFKELQNFLK | ELNIQVDDSY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARKIFKECDH | SQTDSLEDEE | IETFYKILTQ | RKEIDRTFEE | ATGSKETLSV | DQLVTFLQHQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QREEEAGPAL | ALSLIERYEP | SETAKAQRQM | TKDGFLMYLL | SADGSAFDLA | HRRVYQDMDQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLSHYLVSSS | HNTYLLEDQL | TGPSSTEAYI | RALCKGCRCL | ELDCWDGPNQ | EPIIYHGYTF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSKILFCDVV | RAIRDYAFKA | SPYPVILSLE | NHCSLEQQRV | MARHLRTLLG | PMLLDRPLDG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVTSLPSPEQ | LRGKILLKGK | KLGGLFPPGG | EGGPEATVVS | DEDEAAEMED | EAVRSQVQHK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKEDKLRLAK | ELSDMVIYCK | SVHFRGFPSS | GTSGQAFYEM | SSFSENRALR | LLQESGNSFV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RHNVNHLSRI | YPAGWRTDSS | NYSPVEMWNG | GCQIVALNFQ | TPGSEMDVYQ | GRFLDNGACG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YVLKPAFLRD | PNSTFNSRAL | AHGPWWTPKR | LNVRVISGQQ | LPKVNKNKNS | IVDPKVTVEI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HGVSRDVASR | QTAVVTNNGF | NPWWDTELEF | EVAVPELALV | RFVVEDYDAS | SKNDFIGQST |
| 730 | 740 | 750 | |||
| IPLKSLKQGY | RHIHLLSKNG | DQHPSATLFV | KVALQD |