Q56W08

PR
Gene name
PLC3 (ATPLC1, At4g38530, F20M13.90)
Protein name
Phosphoinositide phospholipase C 3
Names
Phosphoinositide phospholipase PLC3, AtPLC1F, AtPLC3, PI-PLC3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G38530
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

127-370 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q56W08

Entry ID Method Resolution Chain Position Source
AF-Q56W08-F1 Predicted AlphaFoldDB

33 variants for Q56W08

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_18020733_T_A 9 F>Y No 1000Genomes
ENSVATH06849366 32 A>V No 1000Genomes
ENSVATH00558403 49 S>G No 1000Genomes
tmp_4_18020865_G_A 53 G>E No 1000Genomes
ENSVATH12483098 53 G>R No 1000Genomes
ENSVATH00558404 63 Q>H No 1000Genomes
tmp_4_18020926_C_A 73 N>K No 1000Genomes
tmp_4_18021003_C_A 99 P>H No 1000Genomes
tmp_4_18021103_T_G 104 V>G No 1000Genomes
tmp_4_18021213_C_A 141 Q>K No 1000Genomes
tmp_4_18021279_G_T 163 A>S No 1000Genomes
ENSVATH06849370 164 E>A No 1000Genomes
ENSVATH06849375 209 Q>K No 1000Genomes
ENSVATH14356991 227 R>S No 1000Genomes
ENSVATH12483102 249 T>M No 1000Genomes
ENSVATH12483103 258 S>I No 1000Genomes
ENSVATH12483103 258 S>N No 1000Genomes
ENSVATH12483104 267 P>S No 1000Genomes
tmp_4_18021811_A_C 283 E>D No 1000Genomes
tmp_4_18021851_G_T 297 D>Y No 1000Genomes
ENSVATH06849377 308 D>V No 1000Genomes
ENSVATH06849378 324 V>A No 1000Genomes
ENSVATH06849379 336 R>S No 1000Genomes
ENSVATH12483118 393 Q>E No 1000Genomes
tmp_4_18022428_A_T 434 I>F No 1000Genomes
tmp_4_18022449_G_A 441 D>N No 1000Genomes
ENSVATH06849381 442 L>F No 1000Genomes
tmp_4_18022479_C_A 451 Q>K No 1000Genomes
ENSVATH14356992 461 I>T No 1000Genomes
ENSVATH02976379 464 A>T No 1000Genomes
tmp_4_18022662_G_A 487 G>S No 1000Genomes
tmp_4_18022779_C_A 526 L>M No 1000Genomes
tmp_4_18022783_C_T 527 P>L No 1000Genomes

No associated diseases with Q56W08

7 regional properties for Q56W08

Type Name Position InterPro Accession
domain Protein kinase domain 262 - 521 IPR000719
domain SH2 domain 136 - 237 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 262 - 515 IPR001245
domain SH3 domain 71 - 132 IPR001452
active_site Tyrosine-protein kinase, active site 377 - 389 IPR008266
binding_site Protein kinase, ATP binding site 268 - 290 IPR017441
domain Tyrosine-protein kinase, catalytic domain 262 - 517 IPR020635

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

43 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q00722 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Homo sapiens (Human) EV
Q01970 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Homo sapiens (Human) EV
Q9NQ66 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Homo sapiens (Human) EV
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q15147 PLCB4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10686 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Rattus norvegicus (Rat) EV
P24135 Plcg2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Rattus norvegicus (Rat) SS
O89040 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Rattus norvegicus (Rat) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
P10687 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q99JE6 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Rattus norvegicus (Rat) SS
G5EBH0 egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Caenorhabditis elegans SS
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSESFKVCFC CSRSFKEKTR QPPVSIKRLF EAYSRNGKMS FDELLRFVSE VQGERHAGLD
70 80 90 100 110 120
YVQDIFHSVK HHNVFHHHGL VHLNAFYRYL FSDTNSPLPM SGQVHHDMKA PLSHYFVYTG
130 140 150 160 170 180
HNSYLTGNQV NSRSSVEPIV QALRKGVKVI ELDLWPNPSG NAAEVRHGRT LTSHEDLQKC
190 200 210 220 230 240
LTAIKDNAFH VSDYPVIITL EDHLPPKLQA QVAKMLTKTY RGMLFRRVSE SFKHFPSPEE
250 260 270 280 290 300
LKGKILISTK PPKEYLESKT VHTTRTPTVK ETSWNRVANK ILEEYKDMES EAVGYRDLIA
310 320 330 340 350 360
IHAANCKDPS KDCLSDDPEK PIRVSMDEQW LDTMVRTRGT DLVRFTQRNL VRIYPKGTRV
370 380 390 400 410 420
DSSNYDPHVG WTHGAQMVAF NMQGHGKQLW IMQGMFRGNG GCGYVKKPRI LLDEHTLFDP
430 440 450 460 470 480
CKRFPIKTTL KVKIYTGEGW DLDFHHTHFD QYSPPDFFVK IGIAGVPRDT VSYRTETAVD
490 500 510 520 530 540
QWFPIWGNDE FLFQLSVPEL ALLWFKVQDY DNDTQNDFAG QTCLPLPELK SGVRAVRLHD
550 560
RTGKAYKNTR LLVSFALDPP YTFR