Q9SNV9
PR
Gene name |
NRAMP3 (At2g23150, F21P24.21) |
Protein name |
Metal transporter Nramp3 |
Names |
AtNramp3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G23150 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SNV9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SNV9-F1 | Predicted | AlphaFoldDB |
22 variants for Q9SNV9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05563540 | 2 | P>S | No | 1000Genomes | |
| ENSVATH13344269 | 4 | L>F | No | 1000Genomes | |
| ENSVATH05563538 | 8 | E>D | No | 1000Genomes | |
| ENSVATH05563537 | 10 | L>F | No | 1000Genomes | |
| ENSVATH13344268 | 16 | E>V | No | 1000Genomes | |
| ENSVATH01872614 | 18 | E>D | No | 1000Genomes | |
| tmp_2_9858322_C_A | 82 | A>S | No | 1000Genomes | |
| ENSVATH05563534 | 99 | A>S | No | 1000Genomes | |
| tmp_2_9858195_C_T | 124 | R>H | No | 1000Genomes | |
| tmp_2_9858100_T_C | 156 | I>V | No | 1000Genomes | |
| tmp_2_9857585_G_T | 180 | F>L | No | 1000Genomes | |
| ENSVATH05563520 | 220 | S>A | No | 1000Genomes | |
| ENSVATH05563520 | 220 | S>P | No | 1000Genomes | |
| tmp_2_9857455_T_C | 224 | I>V | No | 1000Genomes | |
| tmp_2_9857236_T_G | 266 | K>T | No | 1000Genomes | |
| tmp_2_9857110_G_A | 308 | T>I | No | 1000Genomes | |
| ENSVATH00243175 | 389 | V>I | No | 1000Genomes | |
| tmp_2_9856735_C_G | 433 | G>A | No | 1000Genomes | |
| ENSVATH01872598 | 433 | G>S | No | 1000Genomes | |
| tmp_2_9856714_A_G | 440 | L>S | No | 1000Genomes | |
| tmp_2_9856534_T_C | 473 | Y>C | No | 1000Genomes | |
| tmp_2_9856495_G_A | 486 | A>V | No | 1000Genomes |
No associated diseases with Q9SNV9
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadmium ion transmembrane transporter activity | Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. |
| manganese ion transmembrane transporter activity | Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of reactive oxygen species metabolic process | Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to zinc ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27981 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Bos taurus (Bovine) | PR |
| P49279 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Homo sapiens (Human) | PR |
| P49281 | SLC11A2 | Natural resistance-associated macrophage protein 2 | Homo sapiens (Human) | PR |
| P41251 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Mus musculus (Mouse) | PR |
| P49282 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Mus musculus (Mouse) | PR |
| O77741 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Sus scrofa (Pig) | PR |
| P70553 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Rattus norvegicus (Rat) | PR |
| O54902 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Rattus norvegicus (Rat) | PR |
| Q6ZG85 | NRAT1 | Metal transporter NRAT1 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QN30 | NRAMP6 | Metal transporter Nramp6 | Oryza sativa subsp japonica (Rice) | PR |
| Q9C6B2 | NRAMP2 | Metal transporter Nramp2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SN36 | NRAMP5 | Metal transporter Nramp5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPQLENNEPL | LINEEEEEET | AYDETEKVHI | VRNEEEDDLE | HGVGCGGAPP | FSWKKLWLFT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPGFLMSIAF | LDPGNLEGDL | QAGAVAGYSL | LWLLMWATAM | GLLVQLLSAR | LGVATGRHLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELCRDEYPTW | ARMVLWVMAE | LALIGSDIQE | VIGSAIAIKI | LSNGILPLWA | GVVITALDCF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFLFLENYGI | RKLEAVFAVL | IATMGVSFAW | MFGQAKPSGS | ELLIGILVPK | LSSRTIQKAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVVGCIIMPH | NVFLHSALVQ | SREVDKRQKY | RVQEALNYYT | IESTIALFIS | FLINLFVTTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FAKGFYNTDL | ANSIGLVNAG | QYLQEKYGGG | VFPILYIWAI | GLLAAGQSST | ITGTYAGQFI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MGGFLNFKMK | KWLRALITRS | CAIIPTIIVA | LVFDSSEATL | DVLNEWLNVL | QSIQIPFALI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLLCLVSKEQ | IMGSFKIGPL | YKTIAWLVAA | LVIMINGYLL | LEFFSNEVSG | IVYTGFVTLF |
| 490 | 500 | ||||
| TASYGAFILY | LIARGITFTP | WPFKAESSH |