O77741
Gene name |
SLC11A1 (NRAMP1) |
Protein name |
Natural resistance-associated macrophage protein 1 |
Names |
NRAMP 1, Solute carrier family 11 member 1 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:396764 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O77741
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O77741-F1 | Predicted | AlphaFoldDB |
No variants for O77741
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O77741 | |||||
No associated diseases with O77741
No regional properties for O77741
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O77741 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion transmembrane transporter activity | Enables the transfer of metal ions from one side of a membrane to the other. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27981 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Bos taurus (Bovine) | PR |
| P49281 | SLC11A2 | Natural resistance-associated macrophage protein 2 | Homo sapiens (Human) | PR |
| P49279 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Homo sapiens (Human) | PR |
| P49282 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Mus musculus (Mouse) | PR |
| P41251 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Mus musculus (Mouse) | PR |
| O54902 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Rattus norvegicus (Rat) | PR |
| P70553 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Rattus norvegicus (Rat) | PR |
| Q6ZG85 | NRAT1 | Metal transporter NRAT1 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QN30 | NRAMP6 | Metal transporter Nramp6 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SNV9 | NRAMP3 | Metal transporter Nramp3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SN36 | NRAMP5 | Metal transporter Nramp5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6B2 | NRAMP2 | Metal transporter Nramp2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGDTDPPKQ | SRTQYGSISS | SPSPGPPQVP | PGGTYLSEKI | PIPNAEPGTF | SLRKLWAFTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGFLMSIAYL | DPGNIQSDLQ | AGAVAGFKLL | WVLLWATVLG | LLCQRLAARL | GVVTGKDLGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ICHLYYPKVP | RTLLWLNMEL | AIVGSDMQEV | IGTAIAFNLL | SAGRIPLWGG | VLITVVDTFF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLYLNNYGLR | KLEAFFAFLI | AIMAFTFGYE | YVVARPAQGA | LLRGLFLPSC | SGCGQPELLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVGIVGAIIM | PHNIYLHSAL | VKSREVDRTR | REDIREANMY | FLIESTIALF | VSFFINLFVM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVFGQAFYQQ | TNQAAFNICA | NSSLHDYAKI | FPRNNLTVAV | DFYQGGVILG | CLFGPAALYI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WAVGLLAAGQ | SSTMTGTYAG | QFVMEGFLKL | RWSRFARLLL | TRSCAILPAL | LVAVFKELQD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSSLNDLLNV | LQSLLLPFAV | LPILTFTSMP | ALMQEFASGR | VNKVITSSIM | LLVCAINFYF |
| 490 | 500 | 510 | 520 | 530 | |
| LVSYLPSLPH | PAYFGLVALL | AVIYLGLTTY | LVWTCLIAHG | ATLLVHSSHQ | HFLYGLLE |