Q9SN36
PR
Gene name |
NRAMP5 (At4g18790, F28A21.200) |
Protein name |
Metal transporter Nramp5 |
Names |
AtNramp5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G18790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SN36
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SN36-F1 | Predicted | AlphaFoldDB |
62 variants for Q9SN36
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02876507 | 3 | G>E | No | 1000Genomes | |
| ENSVATH02876507 | 3 | G>V | No | 1000Genomes | |
| tmp_4_10319588_G_T | 25 | R>S | No | 1000Genomes | |
| tmp_4_10319579_C_T | 28 | V>I | No | 1000Genomes | |
| ENSVATH00520795 | 30 | E>D | No | 1000Genomes | |
| tmp_4_10319561_G_A | 34 | P>S | No | 1000Genomes | |
| tmp_4_10319551_T_C | 37 | D>G | No | 1000Genomes | |
| ENSVATH14249400 | 40 | H>Y | No | 1000Genomes | |
| ENSVATH11988382 | 48 | I>T | No | 1000Genomes | |
| ENSVATH00520793 | 48 | I>V | No | 1000Genomes | |
| ENSVATH02876504 | 56 | D>E | No | 1000Genomes | |
| ENSVATH06718878 | 64 | P>L | No | 1000Genomes | |
| tmp_4_10319471_G_A | 64 | P>S | No | 1000Genomes | |
| ENSVATH06718877 | 68 | A>E | No | 1000Genomes | |
| tmp_4_10319452_A_T | 70 | L>Q | No | 1000Genomes | |
| tmp_4_10319354_A_T | 103 | S>T | No | 1000Genomes | |
| tmp_4_10319339_G_A | 108 | L>F | No | 1000Genomes | |
| ENSVATH00520788 | 114 | M>I | No | 1000Genomes | |
| tmp_4_10319279_C_T | 128 | A>T | No | 1000Genomes | |
| tmp_4_10319244_A_C | 139 | S>R | No | 1000Genomes | |
| ENSVATH06718875 | 144 | W>L | No | 1000Genomes | |
| ENSVATH11988378 | 153 | A>T | No | 1000Genomes | |
| ENSVATH00520784 | 170 | I>T | No | 1000Genomes | |
| tmp_4_10319113_C_A | 183 | W>L | No | 1000Genomes | |
| tmp_4_10318931_T_G | 201 | K>T | No | 1000Genomes | |
| tmp_4_10318922_A_T | 204 | M>K | No | 1000Genomes | |
| ENSVATH02876495 | 224 | W>C | No | 1000Genomes | |
| tmp_4_10318731_A_G | 241 | I>T | No | 1000Genomes | |
| ENSVATH06718867 | 244 | K>R | No | 1000Genomes | |
| tmp_4_10318705_T_G | 250 | I>L | No | 1000Genomes | |
| tmp_4_10318704_A_C | 250 | I>S | No | 1000Genomes | |
| tmp_4_10318623_T_A | 277 | K>M | No | 1000Genomes | |
| ENSVATH06718865 | 290 | L>I | No | 1000Genomes | |
| ENSVATH00520776 | 291 | N>K | No | 1000Genomes | |
| ENSVATH11988277 | 294 | T>S | No | 1000Genomes | |
| ENSVATH06718864 | 301 | L>V | No | 1000Genomes | |
| ENSVATH06718863 | 324 | Q>H | No | 1000Genomes | |
| tmp_4_10318455_G_A | 333 | A>V | No | 1000Genomes | |
| ENSVATH00520772 | 335 | Y>H | No | 1000Genomes | |
| tmp_4_10318444_G_T | 337 | L>I | No | 1000Genomes | |
| tmp_4_10318319_G_C | 378 | F>L | No | 1000Genomes | |
| tmp_4_10318285_A_T | 390 | F>I | No | 1000Genomes | |
| tmp_4_10318235_C_G | 406 | M>I | No | 1000Genomes | |
| tmp_4_10318224_G_T | 410 | S>Y | No | 1000Genomes | |
| tmp_4_10318194_C_A | 420 | W>L | No | 1000Genomes | |
| ENSVATH06718854 | 432 | A>V | No | 1000Genomes | |
| ENSVATH02876485 | 444 | H>N | No | 1000Genomes | |
| ENSVATH00520766 | 448 | V>L | No | 1000Genomes | |
| tmp_4_10318100_G_C | 451 | I>M | No | 1000Genomes | |
| ENSVATH06718852 | 454 | S>L | No | 1000Genomes | |
| ENSVATH06718853 | 454 | S>P | No | 1000Genomes | |
| tmp_4_10317963_T_C | 472 | Y>C | No | 1000Genomes | |
| tmp_4_10317928_C_G | 484 | G>R | No | 1000Genomes | |
| tmp_4_10317919_C_G | 487 | V>L | No | 1000Genomes | |
| ENSVATH02876478 | 493 | G>A | No | 1000Genomes | |
| ENSVATH02876477 | 496 | V>I | No | 1000Genomes | |
| tmp_4_10317849_C_T | 510 | S>N | No | 1000Genomes | |
| tmp_4_10317828_G_A,T | 517 | S>* | No | 1000Genomes | |
| tmp_4_10317828_G_A,T | 517 | S>L | No | 1000Genomes | |
| tmp_4_10317814_A_G | 522 | S>P | No | 1000Genomes | |
| tmp_4_10317809_C_G | 523 | E>D | No | 1000Genomes | |
| tmp_4_10317793_C_A | 529 | E>* | No | 1000Genomes |
No associated diseases with Q9SN36
No regional properties for Q9SN36
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9SN36 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadmium ion transmembrane transporter activity | Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. |
| manganese ion transmembrane transporter activity | Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27981 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Bos taurus (Bovine) | PR |
| P49279 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Homo sapiens (Human) | PR |
| P49281 | SLC11A2 | Natural resistance-associated macrophage protein 2 | Homo sapiens (Human) | PR |
| P41251 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Mus musculus (Mouse) | PR |
| P49282 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Mus musculus (Mouse) | PR |
| O77741 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Sus scrofa (Pig) | PR |
| P70553 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Rattus norvegicus (Rat) | PR |
| O54902 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Rattus norvegicus (Rat) | PR |
| Q6ZG85 | NRAT1 | Metal transporter NRAT1 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QN30 | NRAMP6 | Metal transporter Nramp6 | Oryza sativa subsp japonica (Rice) | PR |
| Q9C6B2 | NRAMP2 | Metal transporter Nramp2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNV9 | NRAMP3 | Metal transporter Nramp3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGSTVSRQE | NSPKRPNDSN | GEFKRLLVPE | TSQPEEDELH | ESPPENQILN | VEEDRDKTYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVPPFSWAKL | WKFTGPGFLM | SIAFLDPGNI | EGDLQAGAVA | GYSLLWLLLW | ATLMGLLMQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSARIGVATG | RHLAEICRSE | YPSWARILLW | FMAEVALIGA | DIQEVIGSAI | ALQILTRGFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PIWVGVIITS | FDCFLISYLE | KCGMRKLEGL | FAVLIATMAL | SFAWMFNETK | PSVEELFIGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIPKLGSKTI | REAVGVVGCV | ITPHNVFLHS | ALVQSRKTDP | KEINRVQEAL | NYYTIESSAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFVSFMINLF | VTAVFAKGFY | GTKQADSIGL | VNAGYYLQEK | YGGGVFPILY | IWGIGLLAAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QSSTITGTYA | GQFIMEGFLD | LQMEQWLSAF | ITRSFAIVPT | MFVAIMFNTS | EGSLDVLNEW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LNILQSMQIP | FAVIPLLTMV | SNEHIMGVFK | IGPSLEKLAW | TVAVFVMMIN | GYLLLDFFMA |
| 490 | 500 | 510 | 520 | ||
| EVEGFLVGFL | VFGGVVGYIS | FIIYLVSYRS | SQSSSWSSLE | MSERVVSTET |