Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6ZG85

Entry ID Method Resolution Chain Position Source
AF-Q6ZG85-F1 Predicted AlphaFoldDB

No variants for Q6ZG85

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6ZG85

No associated diseases with Q6ZG85

No regional properties for Q6ZG85

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6ZG85

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
aluminum ion transmembrane transporter activity Enables the transfer of aluminum (Al) ions from one side of a membrane to the other.
metal ion transmembrane transporter activity Enables the transfer of metal ions from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
aluminum cation transport The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to aluminum ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27981 SLC11A1 Natural resistance-associated macrophage protein 1 Bos taurus (Bovine) PR
P49279 SLC11A1 Natural resistance-associated macrophage protein 1 Homo sapiens (Human) PR
P49281 SLC11A2 Natural resistance-associated macrophage protein 2 Homo sapiens (Human) PR
P41251 Slc11a1 Natural resistance-associated macrophage protein 1 Mus musculus (Mouse) PR
P49282 Slc11a2 Natural resistance-associated macrophage protein 2 Mus musculus (Mouse) PR
O77741 SLC11A1 Natural resistance-associated macrophage protein 1 Sus scrofa (Pig) PR
P70553 Slc11a1 Natural resistance-associated macrophage protein 1 Rattus norvegicus (Rat) PR
O54902 Slc11a2 Natural resistance-associated macrophage protein 2 Rattus norvegicus (Rat) PR
Q2QN30 NRAMP6 Metal transporter Nramp6 Oryza sativa subsp japonica (Rice) PR
Q9C6B2 NRAMP2 Metal transporter Nramp2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNV9 NRAMP3 Metal transporter Nramp3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SN36 NRAMP5 Metal transporter Nramp5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEGTGEMREV GRETLHGGVV QSVSETDEYK EKTIDSEKDG QFRVQPRWRK FLAHVGPGAL
70 80 90 100 110 120
VAIGFLDPSN LETDMQAGAD FKYELLWVIL VGMVFALLIQ TLAANLGVKT GRHLAELCRE
130 140 150 160 170 180
EYPHYVNIFL WIIAELAVIS DDIPEVLGTA FAFNILLKIP VWAGVILTVF STLLLLGVQR
190 200 210 220 230 240
FGARKLEFII AAFMFTMAAC FFGELSYLRP SAGEVVKGMF VPSLQGKGAA ANAIALFGAI
250 260 270 280 290 300
ITPYNLFLHS ALVLSRKTPR SDKSIRAACR YFLIECSLAF IVAFLINVSV VVVAGSICNA
310 320 330 340 350 360
NNLSPADANT CGDLTLQSTP LLLRNVLGRS SSVVYAVALL ASGQSTTISC TFAGQVIMQG
370 380 390 400 410 420
FLDMKMKNWV RNLITRVIAI APSLIVSIVS GPSGAGKLII LSSMILSFEL PFALIPLLKF
430 440 450 460 470 480
CNSSKKVGPL KESIYTVVIA WILSFALIVV NTYFLVWTYV DWLVHNNLPK YANGLISVVV
490 500 510 520 530 540
FALMAAYLVA VVYLTFRKDT VATYVPVPER AQAQVEAGGT PVVDASAADE DQPAPYRKDL
ADASM