AiPD: Autoinhibited Protein Database

Gene name	NRAMP2 (At1g47240, F8G22.4)
Protein name	Metal transporter Nramp2
Names	AtNramp2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G47240
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

7-82 (Predicted disordered autoinhibitory region) PR

7-82 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9C6B2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13399714	7	E>K	No	1000Genomes
tmp_1_17311281_C_G	10	E>Q	No	1000Genomes
ENSVATH04885490	14	D>N	No	1000Genomes
ENSVATH01303113	15	R>H	No	1000Genomes
ENSVATH00082793	29	T>S	No	1000Genomes
ENSVATH01303112	37	F>L	No	1000Genomes
tmp_1_17311189_G_C	40	N>K	No	1000Genomes
tmp_1_17311179_G_T	44	L>I	No	1000Genomes
tmp_1_17311167_A_G	48	F>L	No	1000Genomes
ENSVATH04885486	52	D>E	No	1000Genomes
tmp_1_17311134_T_G	59	T>P	No	1000Genomes
ENSVATH14240150	62	P>R	No	1000Genomes
ENSVATH14240148	126	A>T	No	1000Genomes
tmp_1_17310295_G_A	215	T>I	No	1000Genomes
tmp_1_17310239_G_C	234	L>V	No	1000Genomes
ENSVATH13399706	240	L>R	No	1000Genomes
ENSVATH01303078	244	S>G	No	1000Genomes
ENSVATH13399705	278	P>L	No	1000Genomes
ENSVATH00082777	280	R>K	No	1000Genomes
tmp_1_17309962_C_T	297	V>I	No	1000Genomes
tmp_1_17309838_T_A	338	K>M	No	1000Genomes
ENSVATH13399704	343	L>F	No	1000Genomes
tmp_1_17309808_T_A	348	Y>F	No	1000Genomes
tmp_1_17309697_A_G	385	M>T	No	1000Genomes
tmp_1_17309599_A_C	418	W>G	No	1000Genomes
ENSVATH00082776	451	P>T	No	1000Genomes
ENSVATH14240145	487	V>A	No	1000Genomes
tmp_1_17309156_T_C	494	T>A	No	1000Genomes
ENSVATH13399696	511	P>S	No	1000Genomes
ENSVATH13399695	514	W>R	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9C6B2

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

Name	Definition
cadmium ion transmembrane transporter activity	Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.
manganese ion transmembrane transporter activity	Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

Name	Definition
cellular response to manganese ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
manganese ion transmembrane transport	A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
manganese ion transport	The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of unidimensional cell growth	Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one
root hair elongation	The process in which the root hair grows longer.
root morphogenesis	The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q27981	SLC11A1	Natural resistance-associated macrophage protein 1	Bos taurus (Bovine)	PR
P49279	SLC11A1	Natural resistance-associated macrophage protein 1	Homo sapiens (Human)	PR
P49281	SLC11A2	Natural resistance-associated macrophage protein 2	Homo sapiens (Human)	PR
P41251	Slc11a1	Natural resistance-associated macrophage protein 1	Mus musculus (Mouse)	PR
P49282	Slc11a2	Natural resistance-associated macrophage protein 2	Mus musculus (Mouse)	PR
O77741	SLC11A1	Natural resistance-associated macrophage protein 1	Sus scrofa (Pig)	PR
P70553	Slc11a1	Natural resistance-associated macrophage protein 1	Rattus norvegicus (Rat)	PR
O54902	Slc11a2	Natural resistance-associated macrophage protein 2	Rattus norvegicus (Rat)	PR
Q6ZG85	NRAT1	Metal transporter NRAT1	Oryza sativa subsp japonica (Rice)	PR
Q2QN30	NRAMP6	Metal transporter Nramp6	Oryza sativa subsp japonica (Rice)	PR
Q9SN36	NRAMP5	Metal transporter Nramp5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SNV9	NRAMP3	Metal transporter Nramp3	Arabidopsis thaliana (Mouse-ear cress)	PR