Q27981
Gene name |
SLC11A1 (NRAMP1) |
Protein name |
Natural resistance-associated macrophage protein 1 |
Names |
NRAMP 1, Solute carrier family 11 member 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282470 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q27981
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q27981-F1 | Predicted | AlphaFoldDB |
No variants for Q27981
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q27981 | |||||
No associated diseases with Q27981
No regional properties for Q27981
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q27981 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| phagocytic vesicle membrane | The lipid bilayer surrounding a phagocytic vesicle. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadmium ion transmembrane transporter activity | Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. |
| iron ion transmembrane transporter activity | Enables the transfer of iron (Fe) ions from one side of a membrane to the other. |
| manganese ion transmembrane transporter activity | Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. |
| metal cation:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular cadmium ion homeostasis | Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell. |
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49281 | SLC11A2 | Natural resistance-associated macrophage protein 2 | Homo sapiens (Human) | PR |
| P49279 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Homo sapiens (Human) | PR |
| P49282 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Mus musculus (Mouse) | PR |
| P41251 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Mus musculus (Mouse) | PR |
| O77741 | SLC11A1 | Natural resistance-associated macrophage protein 1 | Sus scrofa (Pig) | PR |
| O54902 | Slc11a2 | Natural resistance-associated macrophage protein 2 | Rattus norvegicus (Rat) | PR |
| P70553 | Slc11a1 | Natural resistance-associated macrophage protein 1 | Rattus norvegicus (Rat) | PR |
| Q6ZG85 | NRAT1 | Metal transporter NRAT1 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QN30 | NRAMP6 | Metal transporter Nramp6 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SNV9 | NRAMP3 | Metal transporter Nramp3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SN36 | NRAMP5 | Metal transporter Nramp5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6B2 | NRAMP2 | Metal transporter Nramp2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGDTGPPKQ | GGTRYGSISS | PPSPEPQQAP | PGGTYLSEKI | PIPDTESGTF | SLRKLWAFTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGFLMSIAFL | DPGNIESDLQ | AGAVAGFKLL | WVLLWATVLG | LLCQRLAARL | GVVTGKDLGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VCHLYYPKVP | RILLWLTIEL | AIVGSDMQEV | IGTAIAFSLL | SAGRIPLWGG | VLITVVDTFF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLFLDNYGLR | KLEAFFGFLI | TIMALTFGYE | YVVAQPAQGA | LLQGLFLPSC | PGCGQPELLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVGIIGAIIM | PHNIYLHSSL | VKSREVDRSR | RADIREANMY | FLIEATIALS | VSFLINLFVM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVFGQAFYKQ | TNQAAFNICA | DSSLHDYAPI | FPRNNLTVAV | DIYQGGVILG | CLFGPPALYI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WAVGLLAAGQ | SSTMTGTYAG | QFVMEGFLKL | RWSRFARVLL | TRSCAILPTV | LLAVFRDLRD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSGLNDLLNV | LQSLLLPFAV | LPILTFTSMP | ALMQEFANGL | VSKVITSSIM | VLVCAVNLYF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VISYLPSLPH | PAYFSLVALL | AAAYLGLTTY | LVWTCLITQG | ATLLAHSSHQ | RFLYGLPEED |
| QEKGRTSG |