Q9NAD6
PR
Gene name |
sta-1 |
Protein name |
Signal transducer and activator of transcription 1 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_Y51H4A.17 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9NAD6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9NAD6-F1 | Predicted | AlphaFoldDB |
No variants for Q9NAD6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9NAD6 | |||||
No associated diseases with Q9NAD6
1 regional properties for Q9NAD6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Luciferase-like domain | 1 - 332 | IPR011251 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| dauer larval development | The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61635 | STAT3 | Signal transducer and activator of transcription 3 | Bos taurus (Bovine) | PR |
| Q6DV79 | STAT3 | Signal transducer and activator of transcription 3 | Gallus gallus (Chicken) | PR |
| P51692 | STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens (Human) | PR |
| P52630 | STAT2 | Signal transducer and activator of transcription 2 | Homo sapiens (Human) | PR |
| Q14765 | STAT4 | Signal transducer and activator of transcription 4 | Homo sapiens (Human) | PR |
| P40763 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens (Human) | PR |
| P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (Human) | PR |
| P42229 | STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens (Human) | PR |
| P42230 | Stat5a | Signal transducer and activator of transcription 5A | Mus musculus (Mouse) | PR |
| P42227 | Stat3 | Signal transducer and activator of transcription 3 | Mus musculus (Mouse) | PR |
| P42228 | Stat4 | Signal transducer and activator of transcription 4 | Mus musculus (Mouse) | PR |
| P42225 | Stat1 | Signal transducer and activator of transcription 1 | Mus musculus (Mouse) | PR |
| Q9WVL2 | Stat2 | Signal transducer and activator of transcription 2 | Mus musculus (Mouse) | PR |
| Q19S50 | STAT3 | Signal transducer and activator of transcription 3 | Sus scrofa (Pig) | PR |
| P52631 | Stat3 | Signal transducer and activator of transcription 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMGSSSQELQ | TALTDVSKTC | HHLWEENKDL | QGRFVNELGE | LQRLQMVIAQ | LEQQQRLENV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FTVKQQMTEL | QKRAATLYEH | LTQKRNDIVI | KLNDGTNFAT | MLQTQLIGEK | LFSWKNAQKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQIGMPFDNR | EQLLDEIQIE | FEFLADQNWQ | LNMFSCWMLD | LLRRAPQLND | GLAQATIGKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TAITEQLNKL | LFMLVSQSFI | VSVQPEPVLK | TQHKFVTEVR | LLIGDKLGIR | QHLVNTNVSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KIIAEDEAKQ | LSVDYDAHKE | IRNNKTVGTI | SNDFEKLTMN | ERGHLAAKFN | NSKLTRIAHR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPPPKGASDL | KCAASMQAAT | DQKYALLFFI | TPFQMGNLSK | EEQFDVWTLS | LPIMVTVHGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QDCDAQVAIL | WHRAFASISR | NPNTTDVTAV | TWDNLAIMLR | NKFSLFTGAR | RPLSDSDLAY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSEKMLMPNV | ADQKPITFHR | FAKQAMRDDL | PFSFWEWFFS | IMQLIKQKLL | KFWDEGWCIG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FISKNDASQS | MMMCQHSSFL | LRFSDSQTGA | VSIGFVCEEA | DGQKIPFHLA | PFTIKDLDQL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLASRIASCP | QLKDIRYMYP | AIDKEEMLRF | FESEERHRVG | GGDSPTGYIQ | SEIVMVAKTN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GNFRRMSNAP | SMFGADSPSP | LSVQSKLDWS | PGEVHQNHMM | EMSDELGQIL | TVSDMSGDVE |
| 670 | 680 | 690 | 700 | ||
| TLLGPAFKNN | ITNYNPHDGN | HQHNLHFVDM | SQQGMMQQHH | NQFYPS |