P42227

PR
Gene name
Stat3
Protein name
Signal transducer and activator of transcription 3
Names
Acute-phase response factor
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20848
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P42227

Entry ID Method Resolution Chain Position Source
1BG1 X-ray 225 A A 127-715 PDB
3CWG X-ray 305 A A/B 127-688 PDB
4E68 X-ray 258 A A 127-715 PDB
4ZIA X-ray 270 A A/B/C/D/E 3-127 PDB
AF-P42227-F1 Predicted AlphaFoldDB

37 variants for P42227

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389190939 2 A>T No EVA
rs3389138158 13 R>H No EVA
rs3389173882 73 Q>H No EVA
rs3402071146 73 Q>K No EVA
rs3402582345 73 Q>L No EVA
rs3402815528 75 S>A No EVA
rs3402676224 75 S>Y No EVA
rs3402768362 76 N>I No EVA
rs3389217819 143 M>L No EVA
rs3389213992 145 E>A No EVA
rs3389202215 172 F>S No EVA
rs3389202279 219 S>DG* No EVA
rs3389204465 222 A>V No EVA
rs3389200491 294 K>E No EVA
rs3389211651 301 H>Q No EVA
rs3389217770 345 F>Y No EVA
rs3389173886 352 L>R No EVA
rs3389205676 364 I>L No EVA
rs3389205754 393 V>M No EVA
rs3389197090 418 C>S No EVA
rs3389205714 475 A>G No EVA
rs3389173915 479 W>* No EVA
rs3389164296 523 E>V No EVA
rs3389211656 529 A>T No EVA
rs3389201980 558 G>D No EVA
rs3389190984 574 K>N No EVA
rs3389200510 578 A>S No EVA
rs3389200571 621 F>L No EVA
rs3389207215 632 T>S No EVA
rs3389164293 644 Q>* No EVA
rs3389207136 646 N>I No EVA
rs3413105156 699 P>T No EVA
rs3389164297 714 T>I No EVA
rs3389138155 730 T>A No EVA
rs3389204437 730 T>I No EVA
rs3389207224 770 M>V No EVA
rs3402033652 771 M>S No EVA

No associated diseases with P42227

5 regional properties for P42227

Type Name Position InterPro Accession
domain Glutathione S-transferase, N-terminal 9 - 87 IPR004045
domain Glutathione S-transferase, C-terminal 102 - 194 IPR004046
domain Glutathione S-transferase, C-terminal-like 92 - 209 IPR010987
domain Stringent starvation protein A, N-terminal 11 - 83 IPR034341
domain Stringent starvation protein A, C-terminal 93 - 200 IPR034342

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Predominantly present in the cytoplasm without stimuli
  • Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus
  • The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity)
  • Shuttles between the nucleus and the cytoplasm
  • Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4
  • Constitutive nuclear presence is independent of tyrosine phosphorylation
  • Translocates to the nucleus in the presence of EDN1 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

21 GO annotations of molecular function

Name Definition
CCR5 chemokine receptor binding Binding to a CCR5 chemokine receptor.
chromatin DNA binding Binding to DNA that is assembled into chromatin.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
identical protein binding Binding to an identical protein or proteins.
nuclear glucocorticoid receptor binding Binding to a nuclear glucocorticoid receptor.
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
primary miRNA binding Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein phosphatase binding Binding to a protein phosphatase.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

76 GO annotations of biological process

Name Definition
acute-phase response An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
astrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
cellular response to hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
cellular response to interleukin-17 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.
cellular response to leptin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
cellular response to organic cyclic compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
eating behavior The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
energy homeostasis Any process involved in the balance between food intake (energy input) and energy expenditure.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
growth hormone receptor signaling pathway The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
interleukin-6-mediated signaling pathway The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular receptor signaling pathway The series of molecular signals initiated by a ligand binding to a receptor located within a cell.
leptin-mediated signaling pathway The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
negative regulation of autophagy Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
negative regulation of cell death Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of glycolytic process Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
negative regulation of hydrogen peroxide biosynthetic process Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
negative regulation of neuron death Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
negative regulation of neuron migration Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
negative regulation of primary miRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing.
negative regulation of stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of ATP biosynthetic process Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cytokine production involved in inflammatory response Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.
positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
positive regulation of interleukin-10 production Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
positive regulation of metalloendopeptidase activity Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.
positive regulation of miRNA transcription Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.
positive regulation of miRNA-mediated gene silencing A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA).
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of Notch signaling pathway Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
positive regulation of vascular endothelial cell proliferation Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
postsynapse to nucleus signaling pathway The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
radial glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
receptor signaling pathway via JAK-STAT Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of feeding behavior Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
regulation of mitochondrial membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
regulation of multicellular organism growth Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
response to estradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to leptin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
retinal rod cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.
sexual reproduction A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
somatic stem cell population maintenance Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
T-helper 17 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
T-helper 17 type immune response An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22.
temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P61635 STAT3 Signal transducer and activator of transcription 3 Bos taurus (Bovine) PR
Q6DV79 STAT3 Signal transducer and activator of transcription 3 Gallus gallus (Chicken) PR
P51692 STAT5B Signal transducer and activator of transcription 5B Homo sapiens (Human) PR
P52630 STAT2 Signal transducer and activator of transcription 2 Homo sapiens (Human) PR
P42229 STAT5A Signal transducer and activator of transcription 5A Homo sapiens (Human) PR
P42224 STAT1 Signal transducer and activator of transcription 1-alpha/beta Homo sapiens (Human) PR
Q14765 STAT4 Signal transducer and activator of transcription 4 Homo sapiens (Human) PR
P40763 STAT3 Signal transducer and activator of transcription 3 Homo sapiens (Human) PR
P42228 Stat4 Signal transducer and activator of transcription 4 Mus musculus (Mouse) PR
P42230 Stat5a Signal transducer and activator of transcription 5A Mus musculus (Mouse) PR
P42225 Stat1 Signal transducer and activator of transcription 1 Mus musculus (Mouse) PR
Q9WVL2 Stat2 Signal transducer and activator of transcription 2 Mus musculus (Mouse) PR
Q19S50 STAT3 Signal transducer and activator of transcription 3 Sus scrofa (Pig) PR
P52631 Stat3 Signal transducer and activator of transcription 3 Rattus norvegicus (Rat) PR
Q9NAD6 sta-1 Signal transducer and activator of transcription 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL
70 80 90 100 110 120
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA
130 140 150 160 170 180
TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK
190 200 210 220 230 240
SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL
250 260 270 280 290 300
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350 360
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY
370 380 390 400 410 420
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
430 440 450 460 470 480
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
490 500 510 520 530 540
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
550 560 570 580 590 600
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650 660
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM
670 680 690 700 710 720
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN
730 740 750 760
TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDMD LTSECATSPM