Q6DV79
PR
Gene name |
STAT3 (RCJMB04_38l20) |
Protein name |
Signal transducer and activator of transcription 3 |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:420027 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DV79
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DV79-F1 | Predicted | AlphaFoldDB |
No variants for Q6DV79
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DV79 | |||||
No associated diseases with Q6DV79
5 regional properties for Q6DV79
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH2 domain | 580 - 674 | IPR000980 |
| domain | STAT transcription factor, protein interaction | 2 - 122 | IPR013799 |
| domain | STAT transcription factor, all-alpha domain | 145 - 312 | IPR013800 |
| domain | STAT transcription factor, DNA-binding | 326 - 464 | IPR013801 |
| domain | STAT3, SH2 domain | 554 - 716 | IPR035855 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| eating behavior | The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. |
| eye photoreceptor cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| growth hormone receptor signaling pathway via JAK-STAT | The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. |
| leptin-mediated signaling pathway | The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of multicellular organism growth | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to peptide hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. |
| sexual reproduction | A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). |
| temperature homeostasis | A homeostatic process in which an organism modulates its internal body temperature. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61635 | STAT3 | Signal transducer and activator of transcription 3 | Bos taurus (Bovine) | PR |
| P51692 | STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens (Human) | PR |
| P52630 | STAT2 | Signal transducer and activator of transcription 2 | Homo sapiens (Human) | PR |
| P42229 | STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens (Human) | PR |
| P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (Human) | PR |
| Q14765 | STAT4 | Signal transducer and activator of transcription 4 | Homo sapiens (Human) | PR |
| P40763 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens (Human) | PR |
| P42230 | Stat5a | Signal transducer and activator of transcription 5A | Mus musculus (Mouse) | PR |
| P42228 | Stat4 | Signal transducer and activator of transcription 4 | Mus musculus (Mouse) | PR |
| P42225 | Stat1 | Signal transducer and activator of transcription 1 | Mus musculus (Mouse) | PR |
| Q9WVL2 | Stat2 | Signal transducer and activator of transcription 2 | Mus musculus (Mouse) | PR |
| P42227 | Stat3 | Signal transducer and activator of transcription 3 | Mus musculus (Mouse) | PR |
| Q19S50 | STAT3 | Signal transducer and activator of transcription 3 | Sus scrofa (Pig) | PR |
| P52631 | Stat3 | Signal transducer and activator of transcription 3 | Rattus norvegicus (Rat) | PR |
| Q9NAD6 | sta-1 | Signal transducer and activator of transcription 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQWNQLQQL | DTRYLEQLHQ | LYSDSFPMEL | RQFLAPWIES | QDWAYAANKE | SHATLVFHNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGEIDQQYSR | FLQESNVLYQ | HNLRRIKQFL | QSRYLEKPME | IARIVARCLW | EESRLLQTAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAAQQGGQAT | HPTAAVVTEK | QQMLEQHLQD | VRKRVQDLEQ | KMKVVENLQD | DFDFNYKTLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQGDMQDLNG | NNQSVTRQKM | QQLEQMLTAL | DQMRRGIVSE | LAGLLSAMEY | VQKMLADEEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADWKRRQQIA | CIGGPPNICL | DRLENWITSL | AESQLQTRQQ | IKKLEELQQK | VSYKGDPIVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HRPMLEERIV | ELFRNLMKSA | FVVERQPCMP | MHPDRPLVIK | TGVQFTTKVR | LLVKFPELNY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLKIKVCIDK | DSGDVAALRG | SRKFNILGTN | TKVMNMEESN | NGSLSAEFKH | LTLREQRCGN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGRANCDASL | IVTEELHLIT | FETEVYHQGL | KIDLETHSLP | VVVISNICQM | PNAWASILWY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NMLTNNPKNV | NFFTKPPIGT | WDQVAEVLSW | QFSSTTKRGL | SIEQLTTLAE | KLLGPGVNYS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GCQITWAKFC | KENMAGKGFS | FWVWLDNIID | LVKKYILALW | NEGYIMGFIS | KERERAILST |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KPPGTFLLRF | SESSKEGGIT | FTWVEKDISG | KTQIQSVEPY | TKQQLNSMSF | AEIIMGYKIM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DATNILVSPL | VYLYPDIPKE | EAFGKYCRSE | SQEHSEATDS | GSAAPYLKTK | FICVTPTSFS |
| 730 | 740 | 750 | 760 | 770 | |
| NTIDLPMSPR | TLDSLMQFGN | SSEGAEANAG | GQFESLTFDM | ELTQECASSP | M |