AiPD: Autoinhibited Protein Database

P42229

Gene name	STAT5A (STAT5)
Protein name	Signal transducer and activator of transcription 5A
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6776
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

165-238 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

165-238 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for P42229

Entry ID	Method	Resolution	Chain	Position	Source
7TVA	X-ray	283 A	A/B	136-705	PDB
7TVB	X-ray	265 A	A	136-705	PDB
7UBT	X-ray	235 A	A	136-705	PDB
7UC6	X-ray	310 A	A	136-705	PDB
7UC7	X-ray	310 A	A	136-705	PDB
AF-P42229-F1	Predicted				AlphaFoldDB

471 variants for P42229

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1598364148 RCV000984687 CA399572935	427	A>T	Esophageal atresia [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA399565249 rs1598352590	5	I>V		No	ClinGen Ensembl
CA399565300 rs1343278803	6	Q>H		No	ClinGen gnomAD
CA399565290 rs1598352596	6	Q>P		No	ClinGen Ensembl
CA290745964 rs912872879	7	A>V		No	ClinGen TOPMed
rs763790317 CA8574402	9	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs377341826 CA8574401	9	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	12	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757017517 CA8574404	13	D>A		No	ClinGen ExAC gnomAD
CA8574403 rs751300372	13	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8574405 rs780375123	14	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs574731999 CA8574406	15	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA8574407 rs755081667	17	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs779187594 CA8574408	18	M>T		No	ClinGen ExAC gnomAD
rs1598352641 CA399565650	20	V>G		No	ClinGen Ensembl
rs370309676 CA290746023	22	Y>*		No	ClinGen Ensembl
TCGA novel	22	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs995198459 CA290746031	23	G>D		No	ClinGen Ensembl
CA8574409 rs748592105	23	G>S		No	ClinGen ExAC gnomAD
rs1159853062 CA399565784	26	F>L		No	ClinGen TOPMed
CA8574411 rs773602929	26	F>L		No	ClinGen ExAC gnomAD
CA399565860 rs1401556871	29	E>A		No	ClinGen gnomAD
rs1394549901 CA399565871	30	V>I		No	ClinGen gnomAD
rs1297988744 CA399566763	32	H>Y		No	ClinGen gnomAD
rs776231100 CA399566790	34	L>M		No	ClinGen ExAC TOPMed gnomAD
CA399566821 rs201372597	36	Q>L		No	ClinGen 1000Genomes gnomAD
CA290746037 rs201372597	36	Q>P		No	ClinGen 1000Genomes gnomAD
rs201372597 CA399566819	36	Q>R		No	ClinGen 1000Genomes gnomAD
rs1481988515 CA399566866	39	E>D		No	ClinGen TOPMed gnomAD
CA290746039 rs1027517302	40	S>I		No	ClinGen Ensembl
CA399566892 rs1454587421	41	Q>R		No	ClinGen TOPMed
rs1206590904 CA399566904	42	P>S		No	ClinGen gnomAD
CA399566978 rs1456955120	44	D>Y		No	ClinGen gnomAD
rs747506663 CA8574430	45	A>S		No	ClinGen ExAC TOPMed gnomAD
rs771259226 CA8574431	46	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1397225507 CA399566999	46	I>V		No	ClinGen gnomAD
CA290746167 rs375131176	47	D>E		No	ClinGen ESP TOPMed
CA399567040 rs1038776314	48	L>F		No	ClinGen gnomAD
rs1392651260 CA399567049	49	D>Y		No	ClinGen TOPMed gnomAD
rs1434226137 CA399567073	50	N>S		No	ClinGen gnomAD
rs745515755 CA8574433	51	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	52	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399567114 rs1274649105	53	D>E		No	ClinGen gnomAD
rs531137218 CA290746177	54	R>T		No	ClinGen 1000Genomes
rs1220468054 CA399567166	57	A>P		No	ClinGen gnomAD
rs1263640136 CA399567225	59	Q>P		No	ClinGen gnomAD
CA399567289 rs1227416963	62	E>V		No	ClinGen TOPMed
rs1182781194 CA399567308	63	G>D		No	ClinGen gnomAD
CA8574434 rs769367905	67	E>K		No	ClinGen ExAC gnomAD
CA8574435 rs769367905	67	E>Q		No	ClinGen ExAC gnomAD
rs1406350203 CA399567501	72	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA399567530 rs1348479825	74	H>Y		No	ClinGen gnomAD
CA399567599 rs761894019	76	V>L		No	ClinGen ExAC TOPMed gnomAD
rs761894019 CA8574439	76	V>M		No	ClinGen ExAC TOPMed gnomAD
CA399567631 rs1393325474	78	E>K		No	ClinGen TOPMed
rs750315427 CA8574441	79	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8574442 rs760554653	84	K>T		No	ClinGen ExAC gnomAD
CA399567866 rs1379388842	88	G>E		No	ClinGen TOPMed gnomAD
rs758471182 CA8574445	91	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8574446 rs777761052	92	T>M		No	ClinGen ExAC TOPMed gnomAD
CA399567960 rs777761052	92	T>R		No	ClinGen ExAC TOPMed gnomAD
CA8574448 rs757825498	94	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1239454341 CA399568003	94	L>P		No	ClinGen gnomAD
rs756146419 CA8574465	97	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1435572811 CA399568352	99	D>E		No	ClinGen TOPMed gnomAD
rs564512258 CA8574466	100	R>C		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	100	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399568365 rs1250537354	100	R>H		No	ClinGen gnomAD
CA8574467 rs767962855	103	L>Q		No	ClinGen ExAC gnomAD
rs1362732050 CA399568422	103	L>V		No	ClinGen gnomAD
rs1345820694 CA399568464	106	V>F		No	ClinGen gnomAD
CA399568468 rs1345820694	106	V>I		No	ClinGen gnomAD
rs1218653273 CA399568477	107	R>C		No	ClinGen gnomAD
CA8574468 COSM1383350 rs575765283	107	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs202112433 CA290747176	110	R>Q		No	ClinGen 1000Genomes
rs1331420896 CA399568518	110	R>W		No	ClinGen gnomAD
rs1466765940 CA399568534	111	H>L		No	ClinGen TOPMed
rs149721767 CA8574469	114	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA399568624 rs1567686983	116	E>D		No	ClinGen Ensembl
rs748960746 CA8574471	120	V>G		No	ClinGen ExAC gnomAD
CA399568690 rs1192556801	121	R>G		No	ClinGen TOPMed
CA8574472 rs754656931	121	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1011496377 CA399568763	124	N>K		No	ClinGen TOPMed
CA399568756 rs1413504847	124	N>S		No	ClinGen gnomAD
CA399568772 rs1457480358	125	N>D		No	ClinGen gnomAD
rs746195629 CA8574495	126	C>G		No	ClinGen ExAC gnomAD
rs1483098670 CA399569651	126	C>Y		No	ClinGen gnomAD
CA8574498 rs769660748	129	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1170425734 CA399569681	131	G>E		No	ClinGen gnomAD
rs762072134 CA8574500	131	G>W		No	ClinGen ExAC
CA8574504 rs766742717	136	A>T		No	ClinGen ExAC TOPMed gnomAD
rs754394984 CA8574505	137	M>I		No	ClinGen ExAC gnomAD
rs1439727336 CA399569728	138	S>F		No	ClinGen gnomAD
rs1300544861 CA399569731	139	Q>*		No	ClinGen gnomAD
rs1053522991 CA290749083	140	K>N		No	ClinGen Ensembl
rs759784178 CA8574506	141	H>P		No	ClinGen ExAC TOPMed gnomAD
rs759784178 CA290749091	141	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1300485301 CA399569767	144	I>N		No	ClinGen gnomAD
CA8574509 rs145589652	148	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA290749116 rs942922192	149	E>G		No	ClinGen TOPMed
CA399569801 rs1483942222	149	E>Q		No	ClinGen gnomAD
rs1281822642 CA399569807	150	E>K		No	ClinGen TOPMed
CA8574510 rs141415687	152	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs750973999 CA8574511	154	V>I		No	ClinGen ExAC gnomAD
CA8574512 COSM706314 rs756814024	155	T>M	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1368267339 CA399569834	155	T>P		No	ClinGen TOPMed
rs1448837748 CA399569843	156	Q>R		No	ClinGen gnomAD
rs572323915 CA8574514	159	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs145314397 CA290749126	160	N>I		No	ClinGen ESP
CA8574516 rs147867237	161	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA399569875 rs1366673239	161	E>K		No	ClinGen TOPMed
rs769454500 CA8574515	161	E>V		No	ClinGen ExAC gnomAD
rs1173383835 CA399569892 COSM979458	163	K>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1450941531 CA399569946	171	Y>H		No	ClinGen gnomAD
CA8574518 rs772217852	173	I>L		No	ClinGen ExAC gnomAD
CA8574519 rs773438507	178	E>G		No	ClinGen ExAC gnomAD
CA399570008 rs1233252277	179	S>N		No	ClinGen gnomAD
rs771078037 CA8574521	181	R>G		No	ClinGen ExAC gnomAD
CA399570025 rs1321035996	182	I>V		No	ClinGen gnomAD
CA399570037 rs1452662057	183	Q>H		No	ClinGen TOPMed
CA399571362 rs1157440560	184	A>V		No	ClinGen gnomAD
rs141565869 CA8574548	187	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs141565869 CA399571416	187	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576311406 CA8574549	188	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1269050625 CA399571466	190	A>V		No	ClinGen TOPMed
rs759535072 CA290751539	191	Q>H		No	ClinGen Ensembl
CA290751544 rs950380490	193	S>R		No	ClinGen TOPMed gnomAD
rs1598360082 CA399571505	193	S>R		No	ClinGen Ensembl
CA399571521 rs1314655783	194	P>A		No	ClinGen TOPMed gnomAD
CA8574551 rs200134221	194	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399571517 rs1314655783	194	P>T		No	ClinGen TOPMed gnomAD
rs1220818628 CA399571533	195	Q>*		No	ClinGen gnomAD
CA399571537 rs1289432511	195	Q>R		No	ClinGen gnomAD
rs1598360102 CA399571553	196	E>A		No	ClinGen Ensembl
rs1231666878 CA399571568	197	R>C		No	ClinGen TOPMed gnomAD
CA8574552 rs766259233	197	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766259233 CA8574553	197	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8574555 rs371007974	200	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1480453414 CA399571595	200	R>W		No	ClinGen gnomAD
rs374346157 CA8574557	202	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs747188957 CA8574556	202	T>P		No	ClinGen ExAC gnomAD
rs1404345784 CA399571614	203	A>V		No	ClinGen TOPMed
rs745891584 CA8574559	204	L>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1308159770 CA399571624	205	Q>P		No	ClinGen gnomAD
CA8574560 rs369438268	207	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8574561 rs776108843	207	K>R		No	ClinGen ExAC gnomAD
rs2230123 CA8574563 RCV000967453	209	V>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA290751593 rs2230123	209	V>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2230123 CA290751599	209	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8574562 rs367568442	209	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1227462811 CA399571664	212	E>K		No	ClinGen gnomAD
CA8574564 rs774846322	213	A>V		No	ClinGen ExAC gnomAD
rs767141937 CA8574566	217	R>C		No	ClinGen ExAC gnomAD
CA8574567 rs527783523	217	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs542759072 CA8574570	226	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs542759072 CA8574571	226	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8574572 rs765087246	226	R>H	Variant assessed as Somatic; 0.0005762 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs765087246 CA8574573	226	R>L		No	ClinGen ExAC gnomAD
rs758149061 CA8574574	227	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8574590 rs765171270	231	E>K		No	ClinGen ExAC TOPMed gnomAD
rs990723381 CA290751780	241	R>Q		No	ClinGen TOPMed gnomAD
CA399571869 rs1598360375	241	R>W		No	ClinGen Ensembl
rs1276725885 CA399571922	249	D>H		No	ClinGen gnomAD
CA399571932 rs1368387559	250	D>V		No	ClinGen gnomAD
CA399571937 rs1205339449	251	E>K		No	ClinGen TOPMed
rs1437357154 CA399571961	254	Q>R		No	ClinGen TOPMed
rs1209707048 CA399571984	257	R>Q		No	ClinGen TOPMed gnomAD
CA399571983 rs1331665794	257	R>W		No	ClinGen TOPMed gnomAD
rs1314110489 CA399571989	258	R>Q		No	ClinGen TOPMed
rs1284206697 CA399571988	258	R>W		No	ClinGen TOPMed gnomAD
rs1352317038 CA399572019	263	G>R		No	ClinGen TOPMed
rs763843816 CA8574593	267	P>A		No	ClinGen ExAC gnomAD
rs763843816 CA399572047	267	P>S		No	ClinGen ExAC gnomAD
CA399572053 rs1472811031	268	P>S		No	ClinGen TOPMed gnomAD
CA399572058 rs1217951206	269	E>K		No	ClinGen TOPMed gnomAD
CA399572073 rs1407076899	271	S>G		No	ClinGen TOPMed gnomAD
rs1324110606 CA399572074	271	S>N		No	ClinGen gnomAD
rs1366284221 CA399572084	273	D>N		No	ClinGen gnomAD
rs750660966 CA399572093	274	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8574594 rs750660966	274	V>M		No	ClinGen ExAC TOPMed gnomAD
CA399572106 rs1279376982	276	Q>R		No	ClinGen gnomAD
CA8574613 rs766661960	284	E>G		No	ClinGen ExAC TOPMed gnomAD
CA399572174 rs1416364034 COSM979459	284	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA8574615 rs536235533	290	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs536235533 CA8574616	290	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754146749 CA8574614	290	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8574617 rs753238236	293	I>V		No	ClinGen ExAC gnomAD
CA8574618 rs758760565	294	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs778262335 CA8574619	294	R>H		No	ClinGen ExAC TOPMed gnomAD
CA399572451 rs778262335	294	R>L		No	ClinGen ExAC TOPMed gnomAD
CA290751993 rs919902354	295	R>S		No	ClinGen TOPMed
CA8574620 rs747321897	298	H>P		No	ClinGen ExAC TOPMed gnomAD
CA399572569 rs1279722258	299	L>F		No	ClinGen gnomAD
CA399572579 rs1262344113	299	L>P		No	ClinGen gnomAD
CA399572602 rs1190441220	300	C>F		No	ClinGen gnomAD
CA399572594 rs1459769051	300	C>G		No	ClinGen gnomAD
rs1371380050 CA399572702	305	I>M		No	ClinGen TOPMed gnomAD
rs1177404299 CA399572727	307	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA399572766 rs1598360953	308	P>L		No	ClinGen Ensembl
CA399572811 rs1288171833	310	E>K		No	ClinGen TOPMed
CA8574621 rs757647502	311	E>D		No	ClinGen ExAC gnomAD
rs780789743 CA8574622	312	M>R		No	ClinGen ExAC gnomAD
rs142232293 CA8574623	313	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs576124844 CA8574625	315	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs368204897 CA8574624	315	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1598360976 CA399572961	316	V>G		No	ClinGen Ensembl
rs748826189 CA8574626	316	V>I		No	ClinGen ExAC gnomAD
rs768770625 CA8574627	317	N>S		No	ClinGen ExAC gnomAD
CA8574630 rs767378397	318	A>D		No	ClinGen ExAC TOPMed gnomAD
CA8574629 rs761738519	318	A>T	Variant assessed as Somatic; 4.769e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767378397 CA8574631	318	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1261073234 CA399573019	321	T>M		No	ClinGen gnomAD
rs1203314995 CA399573046	323	I>V		No	ClinGen gnomAD
CA8574633 rs765359444	328	V>M		No	ClinGen ExAC TOPMed gnomAD
CA399573319 rs1363166765	331	T>I		No	ClinGen gnomAD
rs757694677 CA8574658	331	T>P		No	ClinGen ExAC TOPMed gnomAD
rs757694677 CA399573311	331	T>S		No	ClinGen ExAC TOPMed gnomAD
CA8574661 rs756477925	334	I>L		No	ClinGen ExAC TOPMed gnomAD
CA399573369 rs1227680774	334	I>T		No	ClinGen TOPMed
CA8574662 rs779610995	337	Q>L		No	ClinGen ExAC gnomAD
rs753487488 CA8574663	340	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1360131632 CA399573528	344	T>I		No	ClinGen gnomAD
CA399573546 rs1291214433	346	T>N		No	ClinGen gnomAD
rs754555362 CA8574664	346	T>S		No	ClinGen ExAC gnomAD
CA399573574 rs1357354740	349	A>T		No	ClinGen gnomAD
rs778505142 CA8574665	349	A>V		No	ClinGen ExAC gnomAD
rs777748961 COSM1383353 CA8574668	352	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs369452991 CA8574670	353	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1563832 CA8574671 rs372745237	353	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA8574672 rs763105048	357	G>S		No	ClinGen ExAC gnomAD
rs1434706212 CA399573669	358	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA399573707 rs1567691210	360	L>P		No	ClinGen Ensembl
CA399573744 rs1304411117	362	V>A		No	ClinGen gnomAD
rs761867798 CA8574676	362	V>L		No	ClinGen ExAC TOPMed gnomAD
rs761867798 CA8574675	362	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	362	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1194389509 CA399573762	363	H>L		No	ClinGen TOPMed gnomAD
rs1451895133 CA399573800	364	M>I		No	ClinGen TOPMed gnomAD
rs1383250187 CA399573775	364	M>V		No	ClinGen gnomAD
CA8574680 rs750909459	366	P>A		No	ClinGen ExAC gnomAD
rs766714643 CA8574682	367	P>L		No	ClinGen ExAC gnomAD
CA8574683 rs753551295	369	V>L		No	ClinGen ExAC gnomAD
rs1307177657 CA399573862	370	K>R		No	ClinGen gnomAD
rs1479482140 CA399573908	373	I>V		No	ClinGen Ensembl
CA399573953 rs1242466165	375	S>N		No	ClinGen TOPMed
CA399574110 rs1476119431	384	K>E		No	ClinGen gnomAD
rs199711508 CA290752289	386	E>G		No	ClinGen 1000Genomes
CA399574152 rs1186642966	386	E>K		No	ClinGen gnomAD
CA8574686 rs752308916	387	N>I		No	ClinGen ExAC gnomAD
CA399574188 rs1298789302	388	T>A		No	ClinGen TOPMed
CA290752295 rs866679330	389	R>C		No	ClinGen TOPMed gnomAD
VAR_052073 CA8574687 rs2230134	389	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8574688 rs2230134	389	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757871229	390	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA399574225 rs1598361557	390	N>H		No	ClinGen Ensembl
rs763602853 CA8574708	391	E>K		No	ClinGen ExAC gnomAD
rs751458115 CA8574709	399	N>T		No	ClinGen ExAC gnomAD
TCGA novel	402	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142128597 CA290720164	403	M>T		No	ClinGen ESP TOPMed gnomAD
rs1195366097 CA399572427	403	M>V		No	ClinGen TOPMed
TCGA novel	405	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	406	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8574712 rs745711904	408	A>D		No	ClinGen ExAC gnomAD
CA8574713 rs143067673	409	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772056413 CA8574716	411	T>N		No	ClinGen ExAC TOPMed gnomAD
CA8574715 rs748317864	411	T>S		No	ClinGen ExAC gnomAD
rs1426444776 CA399572620	413	S>N		No	ClinGen gnomAD
TCGA novel	414	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8574719 CA8574718 rs747051071	416	F>L		No	ClinGen ExAC gnomAD
CA399572714 rs1286830073	417	R>K		No	ClinGen TOPMed
CA399572740 rs1567692631	418	N>S		No	ClinGen Ensembl
rs113341557 CA290720263	421	L>P		No	ClinGen Ensembl
CA8574742 rs763214446	423	R>K		No	ClinGen ExAC gnomAD
CA290720269 rs936716601	426	R>H		No	ClinGen TOPMed
TCGA novel	427	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8574743 rs768405412	429	R>Q		No	ClinGen ExAC gnomAD
rs988135840 CA290720272	429	R>W		No	ClinGen TOPMed
CA399572965 rs1242408805	430	R>Q		No	ClinGen gnomAD
rs1204224434 CA399572963	430	R>W		No	ClinGen gnomAD
CA8574744 rs773844030	431	G>S		No	ClinGen ExAC gnomAD
CA290720300 rs933596432	435	V>L		No	ClinGen Ensembl
TCGA novel	440	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1475897965 CA399573120	440	F>V		No	ClinGen gnomAD
rs760537067 CA8574748	441	T>A		No	ClinGen ExAC gnomAD
rs1163992121 CA399573146	441	T>I		No	ClinGen gnomAD
CA399573188 rs1171629103	444	F>V		No	ClinGen TOPMed
CA8574751 rs754704026	454	E>K		No	ClinGen ExAC gnomAD
CA399573430 rs1419518818	458	Q>E		No	ClinGen TOPMed
CA8574772 rs751813910	463	S>F		No	ClinGen ExAC gnomAD
rs757623363 CA8574773	465	P>L		No	ClinGen ExAC gnomAD
CA399573798 rs1241569041	469	I>L		No	ClinGen TOPMed
CA399573815 rs1351526729	470	V>I		No	ClinGen gnomAD
CA399573843 rs1307657759	472	G>S		No	ClinGen TOPMed
rs1261086956 CA399573878	473	S>N		No	ClinGen gnomAD
CA290720814 rs893730531	479	T>M		No	ClinGen Ensembl
rs1268638276 CA399574133	486	N>S		No	ClinGen gnomAD
rs370492942 CA290720835	491	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370492942 CA8574777	491	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770483390 CA8574806	498	V>A		No	ClinGen ExAC TOPMed gnomAD
CA399574338 rs1567693543	498	V>L		No	ClinGen Ensembl
CA399574341 rs1320186166	499	P>T		No	ClinGen gnomAD
CA290721149 rs757085900	505	P>L		No	ClinGen gnomAD
CA399574415 rs1465572170 COSM3819620	505	P>S	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1567693569 CA399574422	506	Q>E		No	ClinGen Ensembl
rs1457544257 CA399574438	507	L>Q		No	ClinGen gnomAD
CA8574808 rs532878442	509	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs540666908 CA8574809	510	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs775536794 CA8574810	510	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8574812 rs763931368	511	L>P		No	ClinGen ExAC TOPMed gnomAD
rs773581830 CA8574813	513	M>T		No	ClinGen ExAC gnomAD
CA399574505 rs1311437002	513	M>V		No	ClinGen TOPMed gnomAD
CA399574547 rs1256728534	516	K>T		No	ClinGen TOPMed
CA8574815 rs766618425	518	E>K	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA399574599 rs1463833189	520	Q>H		No	ClinGen TOPMed gnomAD
rs559393296 COSM472812 CA8574816	522	N>S	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs765699656 CA8574818	523	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA399574632 rs1397391541	523	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8574822 rs747374645	526	T>I		No	ClinGen ExAC gnomAD
rs1277934426 CA399574683	528	E>K		No	ClinGen TOPMed
CA399574706 rs1598365757	529	N>T		No	ClinGen Ensembl
rs745410561 CA8574825	531	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1313035517 CA399574763	534	A>V		No	ClinGen TOPMed gnomAD
rs201822478 CA8574827	539	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749177790 CA8574828	543	S>T		No	ClinGen ExAC gnomAD
rs1567693684 CA399574891	544	H>R		No	ClinGen Ensembl
CA8574829 rs768574177	544	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs774354650 CA8574830	547	D>A		No	ClinGen ExAC TOPMed gnomAD
rs930357979 CA290721273	549	S>G		No	ClinGen TOPMed
rs1413897155 CA399574959	549	S>N		No	ClinGen gnomAD
CA290721274 rs930749798	550	G>C		No	ClinGen Ensembl
CA8574831 rs761653964	550	G>D		No	ClinGen ExAC TOPMed gnomAD
CA399574986 rs1432916053 COSM3819622	553	V>M	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA399574997 rs1289500203	554	S>F		No	ClinGen gnomAD
TCGA novel	555	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8574834 rs759563651	560	R>K		No	ClinGen ExAC gnomAD
CA399575105 rs1234388293	562	N>D		No	ClinGen gnomAD
rs775608800 CA8574853	564	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399575141 rs1437867099	565	G>D		No	ClinGen gnomAD
rs764625941 CA8574855	569	T>N		No	ClinGen ExAC gnomAD
CA8574858 rs554580817	570	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA8574857 rs762109838	570	F>L		No	ClinGen ExAC gnomAD
CA290721750 rs200186355	572	Q>*		No	ClinGen Ensembl
rs1356630133 CA399575191	572	Q>R		No	ClinGen gnomAD
rs750047248 CA8574859	576	G>R		No	ClinGen ExAC gnomAD
CA399575230 rs1340409838	577	V>A		No	ClinGen TOPMed
rs1340409838 CA399575231	577	V>G		No	ClinGen TOPMed
TCGA novel	577	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	578	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149159731 CA290721765	578	M>T		No	ClinGen ESP TOPMed gnomAD
CA399575252 rs1598366783	580	V>G		No	ClinGen Ensembl
rs1598366780 CA399575248	580	V>L		No	ClinGen Ensembl
rs1008319751 CA290721784	585	H>D		No	ClinGen TOPMed
rs1313491113 CA399575308	588	H>Y		No	ClinGen TOPMed
CA8574864 rs754502479	591	D>G		No	ClinGen ExAC gnomAD
CA399575363 rs1598366948	594	I>V		No	ClinGen Ensembl
CA399575390 rs1421917063	598	V>L		No	ClinGen gnomAD
CA290721927 rs947670001	605	D>E		No	ClinGen TOPMed
CA8574898 rs776433599	605	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs759189698 CA8574899	608	I>V		No	ClinGen ExAC gnomAD
rs1325348468 CA399575470	609	N>K		No	ClinGen TOPMed gnomAD
rs1276136467 CA399575467	609	N>S		No	ClinGen gnomAD
rs1233888280 CA399575484	611	P>L		No	ClinGen gnomAD
rs1344427649 CA399575487	612	D>Y		No	ClinGen gnomAD
rs1286424849 CA399575493	613	G>R		No	ClinGen gnomAD
rs981674796 CA290721952	616	L>F		No	ClinGen TOPMed
CA8574906 rs780900178	618	R>H		No	ClinGen ExAC gnomAD
rs755284379 CA8574908	624	I>V		No	ClinGen ExAC gnomAD
CA8574910 rs748298777	625	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1427807254 CA399575590	627	I>T		No	ClinGen gnomAD
rs777929785	636	P>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA8574928 rs758514352	636	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8574912 rs140676473 COSM1227816	636	P>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs747078154 CA8574930	638	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8574931 rs771618032	640	L>V		No	ClinGen ExAC TOPMed gnomAD
CA8574932 rs781756513	645	P>L		No	ClinGen ExAC gnomAD
rs1457694572 CA399576087	647	T>I		No	ClinGen gnomAD
rs746268770 CA8574933	648	T>M		No	ClinGen ExAC TOPMed gnomAD
rs768352237 CA8574937	652	S>F		No	ClinGen ExAC gnomAD
rs138484872 CA290722210	659	R>Q		No	ClinGen ESP TOPMed
rs1331759850 CA399576159	659	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1598367606 CA399576177	662	D>G		No	ClinGen Ensembl
TCGA novel	662	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs965085343 CA290722222	667	I>L		No	ClinGen TOPMed
rs1229109558 CA399576220	668	Y>*		No	ClinGen gnomAD
rs1381360419 CA399576218	668	Y>C		No	ClinGen gnomAD
rs1312231711 CA399576222	669	V>M		No	ClinGen gnomAD
CA399576241 rs1266628382	671	P>L		No	ClinGen TOPMed
CA399576253 COSM1227817 rs1220900989	673	R>H	large_intestine Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs750321108 CA8574941	674	P>R		No	ClinGen ExAC TOPMed gnomAD
rs760537590 CA8574942	676	D>H		No	ClinGen ExAC gnomAD
CA8574943 rs766026826	683	Y>C		No	ClinGen ExAC gnomAD
CA290722229 rs372677304	687	L>R		No	ClinGen ESP TOPMed
CA8574944 rs752966031	688	A>P		No	ClinGen ExAC TOPMed gnomAD
CA8574977 rs778121170	690	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	698	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA290722688 rs147521401	700	K>R		No	ClinGen Ensembl
rs1460597702 CA399576458	702	V>L		No	ClinGen gnomAD
rs759275556 CA8574979	703	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8574999 rs769850987	707	V>L		No	ClinGen ExAC TOPMed gnomAD
CA399576511 rs769850987	707	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8575001 rs762820560	709	A>T		No	ClinGen ExAC
TCGA novel	710	S>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8575003 rs772226127	712	D>G		No	ClinGen ExAC gnomAD
rs1285746050 CA399576586	713	A>D		No	ClinGen TOPMed
TCGA novel	713	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1390078501 CA399576597	714	G>A		No	ClinGen TOPMed
CA399576599 rs1403138936	715	G>S		No	ClinGen gnomAD
CA399576628 rs1448164907	717	S>N		No	ClinGen gnomAD
CA8575006 rs200025445	718	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8575007 rs568644507	719	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753107760 CA8575010	721	M>K		No	ClinGen ExAC gnomAD
rs1259743830 CA399576741	727	P>A		No	ClinGen gnomAD
CA399576743 rs1259743830	727	P>S		No	ClinGen gnomAD
CA399576750 rs1318588874	728	A>T		No	ClinGen gnomAD
rs1197869135 CA399576758	728	A>V		No	ClinGen gnomAD
rs773174845 CA8575012	730	C>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	732	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756725119 CA8575015	733	A>P		No	ClinGen ExAC TOPMed gnomAD
rs756725119 CA8575014	733	A>S		No	ClinGen ExAC TOPMed gnomAD
CA399576835 rs1163310172	734	P>H		No	ClinGen gnomAD
rs745362393 CA8575016	734	P>S		No	ClinGen ExAC gnomAD
CA8575017 rs529491430	737	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1298580306 CA399577691	743	D>A		No	ClinGen TOPMed gnomAD
CA399577739 rs1233865390	744	H>Q		No	ClinGen gnomAD
CA399577748 rs1409077573	745	V>L		No	ClinGen Ensembl
CA399577804 rs749996722	747	D>H		No	ClinGen ExAC gnomAD
rs749996722 CA8575035	747	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1173797469 CA399577826	748	Q>E		No	ClinGen Ensembl
CA290723477 rs199677936	752	F>V		No	ClinGen gnomAD
CA290723486 rs891508249	753	D>E		No	ClinGen TOPMed
rs780160492 CA399577934	753	D>H		No	ClinGen ExAC TOPMed gnomAD
rs780160492 CA8575037	753	D>N		No	ClinGen ExAC TOPMed gnomAD
rs567020134 CA8575038	757	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs778831312 CA8575040	761	A>S		No	ClinGen ExAC gnomAD
rs778831312 CA8575041	761	A>T		No	ClinGen ExAC gnomAD
rs1009941223 CA290723519	762	R>G		No	ClinGen Ensembl
rs1029737475 CA399578082	764	V>L		No	ClinGen gnomAD
rs1029737475 CA290723529	764	V>M		No	ClinGen gnomAD
CA290723530 rs985360712	766	E>D		No	ClinGen gnomAD
CA8575043 rs776801677	766	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1018174304 CA290723536	768	L>I		No	ClinGen TOPMed gnomAD
COSM1266907 CA399578132 rs1387284839	769	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA399578131 rs1387284839	769	R>G		No	ClinGen TOPMed gnomAD
CA8575044 rs745972463	769	R>H		No	ClinGen ExAC gnomAD
rs745972463 CA8575045	769	R>L		No	ClinGen ExAC gnomAD
rs149261935 CA8575046	770	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8575047 rs763584326	772	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1264901339 CA399578151	772	M>V		No	ClinGen TOPMed
rs1007564759 CA290723570	774	S>G		No	ClinGen TOPMed
rs1218057565 CA399578181	774	S>N		No	ClinGen gnomAD
rs1249071270 CA399578193	775	L>F		No	ClinGen TOPMed
CA399578203 rs764500316	776	D>A		No	ClinGen ExAC gnomAD
CA8575048 rs764500316	776	D>V		No	ClinGen ExAC gnomAD
CA290723576 rs1001618444	777	S>P		No	ClinGen Ensembl
CA8575049 rs774831875	778	R>C		No	ClinGen ExAC TOPMed gnomAD
rs762056710 CA8575050	778	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs147384091 CA8575051	780	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1180047828 CA399578253	782	P>L		No	ClinGen gnomAD
CA8575053 rs755696784	782	P>S		No	ClinGen ExAC TOPMed gnomAD
rs201999384 CA290723628	783	A>T		No	ClinGen 1000Genomes gnomAD
rs1441088020 CA399578263	783	A>V		No	ClinGen gnomAD
rs139614126 CA8575057	784	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8575056 rs139614126	784	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs930043096 CA399578325	789	A>D		No	ClinGen gnomAD
rs930043096 CA290723633	789	A>V		No	ClinGen gnomAD
CA399578329 rs1319658760	790	R>G		No	ClinGen TOPMed
TCGA novel	790	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399578347 rs1458262882	791	G>D		No	ClinGen gnomAD
rs758087729 CA8575060	792	S>C		No	ClinGen ExAC gnomAD
rs758087729 CA8575059	792	S>F		No	ClinGen ExAC gnomAD
rs746025610 CA8575061	794	S>P		No	ClinGen ExAC gnomAD

No associated diseases with P42229

No regional properties for P42229

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P42229

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Translocated into the nucleus in response to phosphorylation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

3 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

14 GO annotations of biological process

Name	Definition
cytokine-mediated signaling pathway	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
defense response	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
growth hormone receptor signaling pathway via JAK-STAT	The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
lactation	The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
positive regulation of blood vessel endothelial cell migration	Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
receptor signaling pathway via JAK-STAT	Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
reelin-mediated signaling pathway	The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
regulation of cell population proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of multicellular organism growth	Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to peptide hormone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
taurine metabolic process	The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P61635	STAT3	Signal transducer and activator of transcription 3	Bos taurus (Bovine)	PR
Q6DV79	STAT3	Signal transducer and activator of transcription 3	Gallus gallus (Chicken)	PR
P52630	STAT2	Signal transducer and activator of transcription 2	Homo sapiens (Human)	PR
P40763	STAT3	Signal transducer and activator of transcription 3	Homo sapiens (Human)	PR
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	Homo sapiens (Human)	PR
Q14765	STAT4	Signal transducer and activator of transcription 4	Homo sapiens (Human)	PR
P51692	STAT5B	Signal transducer and activator of transcription 5B	Homo sapiens (Human)	PR
P42228	Stat4	Signal transducer and activator of transcription 4	Mus musculus (Mouse)	PR
P42225	Stat1	Signal transducer and activator of transcription 1	Mus musculus (Mouse)	PR
Q9WVL2	Stat2	Signal transducer and activator of transcription 2	Mus musculus (Mouse)	PR
P42227	Stat3	Signal transducer and activator of transcription 3	Mus musculus (Mouse)	PR
P42230	Stat5a	Signal transducer and activator of transcription 5A	Mus musculus (Mouse)	PR
Q19S50	STAT3	Signal transducer and activator of transcription 3	Sus scrofa (Pig)	PR
P52631	Stat3	Signal transducer and activator of transcription 3	Rattus norvegicus (Rat)	PR
Q9NAD6	sta-1	Signal transducer and activator of transcription 1	Caenorhabditis elegans	PR

10	20	30	40	50	60
MAGWIQAQQL	QGDALRQMQV	LYGQHFPIEV	RHYLAQWIES	QPWDAIDLDN	PQDRAQATQL
70	80	90	100	110	120
LEGLVQELQK	KAEHQVGEDG	FLLKIKLGHY	ATQLQKTYDR	CPLELVRCIR	HILYNEQRLV
130	140	150	160	170	180
REANNCSSPA	GILVDAMSQK	HLQINQTFEE	LRLVTQDTEN	ELKKLQQTQE	YFIIQYQESL
190	200	210	220	230	240
RIQAQFAQLA	QLSPQERLSR	ETALQQKQVS	LEAWLQREAQ	TLQQYRVELA	EKHQKTLQLL
250	260	270	280	290	300
RKQQTIILDD	ELIQWKRRQQ	LAGNGGPPEG	SLDVLQSWCE	KLAEIIWQNR	QQIRRAEHLC
310	320	330	340	350	360
QQLPIPGPVE	EMLAEVNATI	TDIISALVTS	TFIIEKQPPQ	VLKTQTKFAA	TVRLLVGGKL
370	380	390	400	410	420
NVHMNPPQVK	ATIISEQQAK	SLLKNENTRN	ECSGEILNNC	CVMEYHQATG	TLSAHFRNMS
430	440	450	460	470	480
LKRIKRADRR	GAESVTEEKF	TVLFESQFSV	GSNELVFQVK	TLSLPVVVIV	HGSQDHNATA
490	500	510	520	530	540
TVLWDNAFAE	PGRVPFAVPD	KVLWPQLCEA	LNMKFKAEVQ	SNRGLTKENL	VFLAQKLFNN
550	560	570	580	590	600
SSSHLEDYSG	LSVSWSQFNR	ENLPGWNYTF	WQWFDGVMEV	LKKHHKPHWN	DGAILGFVNK
610	620	630	640	650	660
QQAHDLLINK	PDGTFLLRFS	DSEIGGITIA	WKFDSPERNL	WNLKPFTTRD	FSIRSLADRL
670	680	690	700	710	720
GDLSYLIYVF	PDRPKDEVFS	KYYTPVLAKA	VDGYVKPQIK	QVVPEFVNAS	ADAGGSSATY
730	740	750	760	770	780
MDQAPSPAVC	PQAPYNMYPQ	NPDHVLDQDG	EFDLDETMDV	ARHVEELLRR	PMDSLDSRLS
790
PPAGLFTSAR	GSLS