P42228
PR
Gene name |
Stat4 |
Protein name |
Signal transducer and activator of transcription 4 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20849 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P42228
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1BGF | X-ray | 145 A | A | 2-123 | PDB |
| AF-P42228-F1 | Predicted | AlphaFoldDB |
No variants for P42228
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P42228 | |||||
No associated diseases with P42228
7 regional properties for P42228
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH2 domain | 570 - 665 | IPR000980 |
| domain | STAT transcription factor, protein interaction | 2 - 122 | IPR013799 |
| domain | STAT transcription factor, all-alpha domain | 144 - 308 | IPR013800 |
| domain | STAT transcription factor, DNA-binding | 323 - 455 | IPR013801 |
| domain | Signal transducer and activator of transcription 4, DNA-binding domain | 317 - 474 | IPR029839 |
| domain | STAT4, SH2 domain | 554 - 701 | IPR035856 |
| domain | Signal transducer and activator of transcription 4, coiled-coil domain | 140 - 313 | IPR046991 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| identical protein binding | Binding to an identical protein or proteins. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to organic substance | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. |
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| hematopoietic stem cell homeostasis | Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. |
| leukocyte proliferation | The expansion of a leukocyte population by cell division. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to peptide hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61635 | STAT3 | Signal transducer and activator of transcription 3 | Bos taurus (Bovine) | PR |
| Q6DV79 | STAT3 | Signal transducer and activator of transcription 3 | Gallus gallus (Chicken) | PR |
| P40763 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens (Human) | PR |
| P51692 | STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens (Human) | PR |
| P52630 | STAT2 | Signal transducer and activator of transcription 2 | Homo sapiens (Human) | PR |
| P42229 | STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens (Human) | PR |
| P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (Human) | PR |
| Q14765 | STAT4 | Signal transducer and activator of transcription 4 | Homo sapiens (Human) | PR |
| P42227 | Stat3 | Signal transducer and activator of transcription 3 | Mus musculus (Mouse) | PR |
| P42230 | Stat5a | Signal transducer and activator of transcription 5A | Mus musculus (Mouse) | PR |
| P42225 | Stat1 | Signal transducer and activator of transcription 1 | Mus musculus (Mouse) | PR |
| Q9WVL2 | Stat2 | Signal transducer and activator of transcription 2 | Mus musculus (Mouse) | PR |
| Q19S50 | STAT3 | Signal transducer and activator of transcription 3 | Sus scrofa (Pig) | PR |
| P52631 | Stat3 | Signal transducer and activator of transcription 3 | Rattus norvegicus (Rat) | PR |
| Q9NAD6 | sta-1 | Signal transducer and activator of transcription 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQWNQVQQL | EIKFLEQVDQ | FYDDNFPMEI | RHLLAQWIET | QDWEVASNNE | TMATILLQNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIQLDEQLGR | VSKEKNLLLI | HNLKRIRKVL | QGKFHGNPMH | VAVVISNCLR | EERRILAAAN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MPIQGPLEKS | LQSSSVSERQ | RNVEHKVSAI | KNSVQMTEQD | TKYLEDLQDE | FDYRYKTIQT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MDQGDKNSIL | VNQEVLTLLQ | EMLNSLDFKR | KEALSKMTQI | VNETDLLMNS | MLLEELQDWK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRQQIACIGG | PLHNGLDQLQ | NCFTLLAESL | FQLRQQLEKL | QEQSTKMTYE | GDPIPAQRAH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLERATFLIY | NLFKNSFVVE | RQPCMPTHPQ | RPMVLKTLIQ | FTVKLRLLIK | LPELNYQVKV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KASIDKNVST | LSNRRFVLCG | THVKAMSSEE | SSNGSLSVEF | RHLQPKEMKC | STGSKGNEGC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HMVTEELHSI | TFETQICLYG | LTINLETSSL | PVVMISNVSQ | LPNAWASIIW | YNVSTNDSQN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LVFFNNPPSV | TLGQLLEVMS | WQFSSYVGRG | LNSEQLNMLA | EKLTVQSNYN | DGHLTWAKFC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KEHLPGKTFT | FWTWLEAILD | LIKKHILPLW | IDGYIMGFVS | KEKERLLLKD | KMPGTFLLRF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SESHLGGITF | TWVDQSENGE | VRFHSVEPYN | KGRLSALAFA | DILRDYKVIM | AENIPENPLK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YLYPDIPKDK | AFGKHYSSQP | CEVSRPTERG | DKGYVPSVFI | PISTIRSDST | EPQSPSDLLP |
| 730 | 740 | ||||
| MSPSAYAVLR | ENLSPTTIET | AMNSPYSAE |