P61635
PR
Gene name |
STAT3 |
Protein name |
Signal transducer and activator of transcription 3 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:508541 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P61635
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P61635-F1 | Predicted | AlphaFoldDB |
No variants for P61635
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P61635 | |||||
No associated diseases with P61635
No regional properties for P61635
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P61635 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin DNA binding | Binding to DNA that is assembled into chromatin. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
25 GO annotations of biological process
| Name | Definition |
|---|---|
| astrocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. |
| cellular response to leptin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. |
| eating behavior | The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. |
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| eye photoreceptor cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| growth hormone receptor signaling pathway via JAK-STAT | The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| interleukin-6-mediated signaling pathway | The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| leptin-mediated signaling pathway | The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of erythrocyte differentiation | Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. |
| positive regulation of Notch signaling pathway | Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| radial glial cell differentiation | The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of feeding behavior | Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to leptin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. |
| sexual reproduction | A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). |
| T-helper 17 cell lineage commitment | The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. |
| T-helper 17 type immune response | An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22. |
| temperature homeostasis | A homeostatic process in which an organism modulates its internal body temperature. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6DV79 | STAT3 | Signal transducer and activator of transcription 3 | Gallus gallus (Chicken) | PR |
| P51692 | STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens (Human) | PR |
| P52630 | STAT2 | Signal transducer and activator of transcription 2 | Homo sapiens (Human) | PR |
| P42229 | STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens (Human) | PR |
| P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (Human) | PR |
| Q14765 | STAT4 | Signal transducer and activator of transcription 4 | Homo sapiens (Human) | PR |
| P40763 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens (Human) | PR |
| P42230 | Stat5a | Signal transducer and activator of transcription 5A | Mus musculus (Mouse) | PR |
| P42228 | Stat4 | Signal transducer and activator of transcription 4 | Mus musculus (Mouse) | PR |
| P42225 | Stat1 | Signal transducer and activator of transcription 1 | Mus musculus (Mouse) | PR |
| Q9WVL2 | Stat2 | Signal transducer and activator of transcription 2 | Mus musculus (Mouse) | PR |
| P42227 | Stat3 | Signal transducer and activator of transcription 3 | Mus musculus (Mouse) | PR |
| Q19S50 | STAT3 | Signal transducer and activator of transcription 3 | Sus scrofa (Pig) | PR |
| P52631 | Stat3 | Signal transducer and activator of transcription 3 | Rattus norvegicus (Rat) | PR |
| Q9NAD6 | sta-1 | Signal transducer and activator of transcription 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQWNQLQQL | DTRYLEQLHQ | LYSDSFPMEL | RQLLAPWIES | QDWAYAASKE | SHATLVFHNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGEIDQQYSR | FLQESNVLYQ | HNLRRIKQFL | QSRYLEKPME | IARIVARCLW | EESRLLQTAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAAQQGGQAN | HPTAAVVTEK | QQMLEQHLQD | VRKRVQDLEQ | KMKVVENLLD | DFDFNYKTLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQGDMQDLNG | NNQSVTRQKM | QQLEQMLTAL | DQMRRSIVSE | LAGLLSAMEY | VQKTLTDEEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADWKRRQQIA | CIGGPPNICL | DRLENWITSL | AESQLQTRQQ | IKKLEELQQK | VSYKGDPIVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HRPMLEERIV | ELFRNLMKSA | FVVERQPCMP | MHPDRPLVIK | TGVQFTTKVR | LLVKFPELNY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLKIKVCIDK | DSGDVAALRG | SRKFNILGTN | TKVMNMEESN | NGSLSAEFKH | LTLREQRCGN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGRANCDASL | IVTEELHLIT | FETEVYHQGL | KIDLETHSLP | VVVISNICQM | PNAWASILWY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NMLTNNPKNV | NFFTKPPIGT | WDQVAEVLSW | QFSSTTKRGL | SIEQLTTLAE | KLLGPGVNYS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GCQITWAKFC | KENMAGKGFS | FWVWLDNIID | LVKKYILALW | NEGYIMGFIS | KERERAILST |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KPPGTCLLRF | SESSKEGGVT | FTWVEKDISG | KTQIQSVEPY | TKQQLNNMSF | AEIIMGYKIM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DATNILVSPL | VYLYPDIPKE | DAFGKYCRPE | SQEHPEADPG | SAAPYLKTKF | ICVTPTTCSN |
| 730 | 740 | 750 | 760 | ||
| TIDLPMSPRT | LDSLMQFGNN | GEAAEPSAGG | QFESLTFDME | LTSECATSPM |