Q9M338
Gene name |
AKR4C11 (At3g53880, F5K20.180) |
Protein name |
Aldo-keto reductase family 4 member C11 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G53880 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M338
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M338-F1 | Predicted | AlphaFoldDB |
41 variants for Q9M338
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06310454 | 4 | E>D | No | 1000Genomes | |
| ENSVATH02501744 | 6 | G>E | No | 1000Genomes | |
| ENSVATH02501745 | 7 | F>Y | No | 1000Genomes | |
| ENSVATH06310455 | 8 | F>L | No | 1000Genomes | |
| ENSVATH00418162 | 24 | W>* | No | 1000Genomes | |
| tmp_3_19953583_A_T | 54 | N>Y | No | 1000Genomes | |
| ENSVATH06310472 | 65 | L>F | No | 1000Genomes | |
| ENSVATH12748957 | 71 | V>L | No | 1000Genomes | |
| ENSVATH00418170 | 85 | T>P | No | 1000Genomes | |
| tmp_3_19954142_T_C | 92 | V>A | No | 1000Genomes | |
| tmp_3_19954147_G_A | 94 | D>N | No | 1000Genomes | |
| ENSVATH06310477 | 97 | N>D | No | 1000Genomes | |
| tmp_3_19954158_C_A | 97 | N>K | No | 1000Genomes | |
| ENSVATH14430750 | 99 | T>S | No | 1000Genomes | |
| ENSVATH06310481 | 118 | R>Q | No | 1000Genomes | |
| ENSVATH06310482 | 127 | K>N | No | 1000Genomes | |
| ENSVATH06310483 | 128 | P>L | No | 1000Genomes | |
| ENSVATH06310484 | 131 | I>V | No | 1000Genomes | |
| tmp_3_19954433_C_A | 133 | P>H | No | 1000Genomes | |
| ENSVATH12748961 | 142 | A>V | No | 1000Genomes | |
| tmp_3_19954462_A_T | 143 | M>L | No | 1000Genomes | |
| tmp_3_19954508_G_A | 158 | S>N | No | 1000Genomes | |
| tmp_3_19954516_T_G | 161 | S>A | No | 1000Genomes | |
| ENSVATH00418177 | 166 | S>T | No | 1000Genomes | |
| tmp_3_19954537_C_G | 168 | L>V | No | 1000Genomes | |
| ENSVATH00418178 | 174 | V>I | No | 1000Genomes | |
| ENSVATH12748964 | 183 | C>* | No | 1000Genomes | |
| ENSVATH14430751 | 217 | V>L | No | 1000Genomes | |
| ENSVATH06310491 | 220 | D>N | No | 1000Genomes | |
| tmp_3_19954807_A_G | 228 | E>G | No | 1000Genomes | |
| ENSVATH02501799 | 230 | I>V | No | 1000Genomes | |
| tmp_3_19954819_A_T | 232 | K>I | No | 1000Genomes | |
| ENSVATH12749037 | 234 | I>M | No | 1000Genomes | |
| ENSVATH06310493 | 241 | T>S | No | 1000Genomes | |
| ENSVATH12749038 | 244 | R>Q | No | 1000Genomes | |
| tmp_3_19954908_A_T | 262 | R>* | No | 1000Genomes | |
| ENSVATH00418182 | 276 | K>E | No | 1000Genomes | |
| ENSVATH06310495 | 276 | K>N | No | 1000Genomes | |
| tmp_3_19954975_A_G | 284 | K>R | No | 1000Genomes | |
| ENSVATH06310499 | 295 | S>P | No | 1000Genomes | |
| ENSVATH06310500 | 298 | H>N | No | 1000Genomes |
No associated diseases with Q9M338
3 regional properties for Q9M338
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aldo/keto reductase, conserved site | 143 - 160 | IPR018170-1 |
| conserved_site | Aldo/keto reductase, conserved site | 254 - 269 | IPR018170-2 |
| domain | NADP-dependent oxidoreductase domain | 20 - 286 | IPR023210 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| alditol:NADP+ 1-oxidoreductase activity | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16116 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Bos taurus (Bovine) | PR |
| O60218 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Homo sapiens (Human) | PR |
| P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Homo sapiens (Human) | PR |
| P45376 | Akr1b1 | Aldo-keto reductase family 1 member B1 | Mus musculus (Mouse) | PR |
| P45377 | Akr1b8 | Aldose reductase-related protein 2 | Mus musculus (Mouse) | PR |
| P80276 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Sus scrofa (Pig) | PR |
| P07943 | Akr1b1 | Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Rat) | PR |
| Q84TF0 | AKR4C10 | Aldo-keto reductase family 4 member C10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0PGJ6 | AKR4C9 | NADPH-dependent aldo-keto reductase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80944 | AKR4C8 | Aldo-keto reductase family 4 member C8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADEIGFFQL | NTGAKIPSVG | LGTWQAAPGV | VGDAVAAAVK | IGYQHIDCAS | RYGNEIEIGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLKKLFDDGV | VKREKLFITS | KIWLTDLDPP | DVQDALNRTL | QDLQLDYVDL | YLMHWPVRLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGTVDFKPEN | IMPIDIPSTW | KAMEALVDSG | KARAIGVSNF | STKKLSDLVE | AARVPPAVNQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VECHPSWQQH | KLHEFCKSKG | IHLSGYSPLG | SPGTTWVKAD | VLKSPVIEMI | AKEIGKSPAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TALRWGLQMG | HSILPKSTNE | GRIRENFDVL | GWSIPKEMFD | KFSKIEQARL | VQGTSFVHET |
| 310 | |||||
| LSPYKTLEEL | WDGEI |