AiPD: Autoinhibited Protein Database

O60218

Gene name	AKR1B10 (AKR1B11)
Protein name	Aldo-keto reductase family 1 member B10
Names	ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57016
EC number	1.1.1.54: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-52 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

21 structures for O60218

Entry ID	Method	Resolution	Chain	Position	Source
1ZUA	X-ray	125 A	X	1-316	PDB
4GA8	X-ray	194 A	A	1-316	PDB
4GAB	X-ray	160 A	A	1-316	PDB
4GQ0	X-ray	210 A	A	1-316	PDB
4GQG	X-ray	192 A	A	1-316	PDB
4I5X	X-ray	210 A	A	1-316	PDB
4ICC	X-ray	175 A	X	1-316	PDB
4JIH	X-ray	230 A	A	1-316	PDB
4JII	X-ray	220 A	X	1-316	PDB
4WEV	X-ray	145 A	X	1-316	PDB
4XZL	X-ray	170 A	X	1-316	PDB
4XZM	X-ray	175 A	X	1-316	PDB
4XZN	X-ray	170 A	X	1-316	PDB
5LIK	X-ray	205 A	X	1-316	PDB
5LIU	X-ray	175 A	X	1-316	PDB
5LIW	X-ray	175 A	X	1-316	PDB
5LIX	X-ray	195 A	X	1-316	PDB
5LIY	X-ray	205 A	X	1-316	PDB
5M2F	X-ray	150 A	X	1-316	PDB
5Y7N	X-ray	250 A	A	1-316	PDB
AF-O60218-F1	Predicted				AlphaFoldDB

298 variants for O60218

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs774817445 CA4493655	2	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	2	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369322002 rs1562928667 COSM3411601	3	T>M	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA4493657 rs772692413	4	F>S		No	ClinGen ExAC gnomAD
rs773276163 CA4493658	6	E>Q		No	ClinGen ExAC gnomAD
CA369322024 rs572830188	7	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572830188 CA4493660	7	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4493661 rs754091937	9	T>I		No	ClinGen ExAC gnomAD
rs149691678 CA4493664 CA4493665	13	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA369322079 rs1330607273	15	I>T		No	ClinGen gnomAD
CA4493667 rs781283353	15	I>V		No	ClinGen ExAC gnomAD
rs1280067316 CA369322115	21	W>S		No	ClinGen TOPMed gnomAD
rs749890611	22	K>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA369322127 rs749890611	22	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1230908738 CA369322124	22	K>R		No	ClinGen gnomAD
CA369322144 rs138887023	23	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138887023 CA4493698	23	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776573145 CA4493700	24	P>L		No	ClinGen ExAC gnomAD
CA4493699 rs771488063	24	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4493702 rs769854371	26	G>S		No	ClinGen ExAC TOPMed gnomAD
CA369322170 rs1297931009	28	V>L		No	ClinGen TOPMed
rs1297931009 CA369322168	28	V>M		No	ClinGen TOPMed
CA4493704 rs761472134	31	A>V		No	ClinGen ExAC gnomAD
rs767386642 CA4493705	33	K>R		No	ClinGen ExAC gnomAD
CA369322224 rs1562929517	36	I>T		No	ClinGen Ensembl
rs892344383 CA369322233	37	D>E		No	ClinGen TOPMed gnomAD
CA4493707 rs760675156	37	D>N		No	ClinGen ExAC gnomAD
rs1198519963 CA369322250	40	Y>C		No	ClinGen gnomAD
rs144002917 CA4493712	41	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144002917 CA4493711	41	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370452533 CA4493710	41	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs996921542 CA167011873	42	H>Y		No	ClinGen TOPMed
CA369322264 rs1255915499	43	I>V		No	ClinGen gnomAD
CA4493714 rs778100620	45	C>R		No	ClinGen ExAC gnomAD
CA369322285 rs1202552408	46	A>T		No	ClinGen gnomAD
rs1477523518 CA369322295	47	Y>C		No	ClinGen gnomAD
CA369322301 rs1168673332	48	V>D		No	ClinGen gnomAD
rs1028307209 CA167011884	48	V>I		No	ClinGen TOPMed
rs757698460 CA4493716	49	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1458770243 CA369322319	51	N>Y		No	ClinGen TOPMed gnomAD
rs955364465 CA167011890	53	H>R		No	ClinGen TOPMed
rs1301987117 CA369322343	54	E>Q		No	ClinGen gnomAD
CA369322354 rs1198656153	55	V>A		No	ClinGen TOPMed
CA369322382 rs749496966	59	I>M		No	ClinGen ExAC gnomAD
CA4493722 rs769056338	60	Q>E		No	ClinGen ExAC gnomAD
CA4493723 rs773135869	60	Q>P		No	ClinGen ExAC gnomAD
rs1211443532 CA369322390	61	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4493724 rs760550433	63	I>N		No	ClinGen ExAC TOPMed gnomAD
CA369322426 rs1482492767	65	E>D		No	ClinGen gnomAD
CA369322428 rs1219310730	66	K>E		No	ClinGen gnomAD
rs770935295 CA4493725	67	A>S		No	ClinGen ExAC gnomAD
rs1488126019 CA369322440	68	V>M		No	ClinGen TOPMed gnomAD
CA369322451 rs1427373734	69	K>M		No	ClinGen gnomAD
CA4493730 rs752209303	70	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4493729 rs752209303	70	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs541818131 CA4493728	70	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA167011974 rs908761663	71	E>K		No	ClinGen TOPMed
rs763744205 CA4493731	73	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1332658900 CA369322475	74	F>L		No	ClinGen TOPMed
rs1414376779 CA369322479	74	F>S		No	ClinGen TOPMed
rs1414376779 CA369322478	74	F>Y		No	ClinGen TOPMed
rs141386431 CA4493734	76	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369322498 rs1397759211	77	S>N		No	ClinGen gnomAD
CA4493761 rs758605056	79	L>S		No	ClinGen ExAC gnomAD
rs143396171 CA4493759	79	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs953989764 CA167012683	80	W>*		No	ClinGen TOPMed gnomAD
CA4493762 rs781034480	80	W>R		No	ClinGen ExAC TOPMed gnomAD
rs769711685 CA4493764	81	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4493763 rs745653060	81	P>T		No	ClinGen ExAC gnomAD
rs748752793 CA4493766	83	F>Y		No	ClinGen ExAC
rs151300112 CA4493767	86	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4493770 rs2303312	87	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4493769 rs2303312 VAR_020077	87	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA369322571 rs2303312	87	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1222831385 CA369322602	92	A>T		No	ClinGen gnomAD
rs1585751827 CA369322612	93	F>S		No	ClinGen Ensembl
TCGA novel	94	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760962667 CA4493774	98	K>E		No	ClinGen ExAC TOPMed gnomAD
rs568395530 CA167012747	99	D>E		No	ClinGen Ensembl
CA4493776 rs754365410	99	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA369322660 rs1257311364	100	L>P		No	ClinGen gnomAD
CA4493777 rs755590380	101	K>T		No	ClinGen ExAC TOPMed gnomAD
CA369322691 rs1472222737	105	L>V		No	ClinGen gnomAD
CA167012779 rs563657501	106	D>Y		No	ClinGen TOPMed
CA4493781 rs372587864	107	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA369322709 rs1227680120	108	Y>D		No	ClinGen TOPMed gnomAD
rs745623300 CA4493782	109	L>P		No	ClinGen ExAC gnomAD
rs755888697 CA4493783	110	I>F		No	ClinGen ExAC gnomAD
CA369322723 rs1400212055	110	I>T		No	ClinGen gnomAD
rs779869150 CA4493784	111	H>D		No	ClinGen ExAC TOPMed gnomAD
CA4493785 rs138234669	111	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1161467816 CA369322740	112	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA369322736 rs1360139938	112	W>*		No	ClinGen gnomAD
rs140738774 CA4493786	114	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369322753 rs1311265753 CA369322752	114	Q>H		No	ClinGen TOPMed gnomAD
CA4493787 rs146306673	115	G>R		No	ClinGen ESP ExAC gnomAD
rs1001820298 CA167012810 CA167012811	117	K>N		No	ClinGen TOPMed gnomAD
rs759990288 CA4493813	119	G>A		No	ClinGen ExAC gnomAD
CA167013415 CA369322810 rs199767638	121	D>E		No	ClinGen TOPMed gnomAD
CA167013440 rs977797786	122	L>F		No	ClinGen TOPMed gnomAD
CA369322815 rs1228322889	122	L>R		No	ClinGen TOPMed
rs866151329 CA167013445	123	F>L		No	ClinGen Ensembl
rs770373251 CA4493814	124	P>S		No	ClinGen ExAC gnomAD
rs139045134 CA4493815	125	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA369322831 rs1562930252	125	K>R		No	ClinGen Ensembl
rs763551589 CA369322843	127	D>N		No	ClinGen ExAC gnomAD
rs763551589 CA4493816	127	D>Y		No	ClinGen ExAC gnomAD
CA167013464 rs200050710	128	K>E		No	ClinGen 1000Genomes
rs201931122 CA167013470	128	K>N		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	129	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1307110178 CA369322873	131	A>G		No	ClinGen TOPMed
CA4493817 rs764062612	131	A>T		No	ClinGen ExAC TOPMed gnomAD
rs751722171 CA4493818	132	I>T		No	ClinGen ExAC gnomAD
CA4493819 COSM1496511 rs762021185	133	G>S	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM109599 CA167013514 rs148486050	134	G>R	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs767733590 CA4493820	137	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs202241431 CA4493821	138	F>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1240363170 CA369322912	138	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754791433 CA4493822	138	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA167013541 rs574158757	140	D>V		No	ClinGen 1000Genomes
rs201265934 CA167013544	141	A>V		No	ClinGen 1000Genomes
TCGA novel	143	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369322969 rs1278345272	144	A>V		No	ClinGen gnomAD
rs1319148710 CA369322971	145	M>V		No	ClinGen TOPMed gnomAD
rs745488997 CA4493850	146	E>A		No	ClinGen ExAC gnomAD
CA369322997 rs755891882	148	L>P		No	ClinGen ExAC TOPMed gnomAD
rs755891882 CA4493851	148	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1257069883 CA369323001	149	V>A		No	ClinGen TOPMed gnomAD
CA4493852 rs780281780	149	V>M		No	ClinGen ExAC TOPMed gnomAD
CA369323005 rs1415157276	150	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA369323011 rs1468618431	151	E>K		No	ClinGen TOPMed
rs1427808653 CA369323025	153	L>M		No	ClinGen gnomAD
CA369323033 rs1379350334	154	V>G		No	ClinGen gnomAD
CA4493855 rs774946368	154	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	156	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748188770 CA4493857	156	A>T		No	ClinGen ExAC gnomAD
rs772109214 CA4493858	157	L>F		No	ClinGen ExAC gnomAD
rs773330080 CA4493859	159	V>F		No	ClinGen ExAC gnomAD
CA369323063 rs1585755761	159	V>G		No	ClinGen Ensembl
CA4493863 rs372195311	163	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs372195311 CA4493862	163	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs377213229 CA167015464	164	H>Y		No	ClinGen ESP gnomAD
CA4493864 rs763895001	165	F>S		No	ClinGen ExAC gnomAD
TCGA novel	166	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369323126 rs1280079840	168	E>D		No	ClinGen gnomAD
CA4493867 rs148661873	168	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs397842944 CA4493868	169	K>R		No	ClinGen ExAC TOPMed gnomAD
CA4493871 rs141276121	172	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4493870 rs779772332	172	N>S		No	ClinGen ExAC TOPMed gnomAD
CA167015580 rs796162477	174	P>H		No	ClinGen Ensembl
rs1184899886 CA369323172	175	G>V		No	ClinGen gnomAD
CA4493872 rs755403083	177	K>I		No	ClinGen ExAC TOPMed gnomAD
CA369323182 rs755403083	177	K>R		No	ClinGen ExAC TOPMed gnomAD
rs150738610 CA4493873	178	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4493875 rs772625603	180	P>L		No	ClinGen ExAC gnomAD
rs772625603 CA369323204	180	P>R		No	ClinGen ExAC gnomAD
rs1350851971 CA369323201	180	P>S		No	ClinGen TOPMed
CA4493876 rs773208886	181	V>L		No	ClinGen ExAC gnomAD
CA369323224 rs1294847595	184	Q>*		No	ClinGen TOPMed gnomAD
CA167015619 rs1050448037	184	Q>H		No	ClinGen TOPMed gnomAD
TCGA novel	185	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760571364 CA4493904	186	E>*		No	ClinGen ExAC TOPMed gnomAD
CA369323248 rs760571364	186	E>K		No	ClinGen ExAC TOPMed gnomAD
CA369323268 rs1356409573	188	H>L		No	ClinGen TOPMed gnomAD
CA369323266 rs1356409573	188	H>P		No	ClinGen TOPMed gnomAD
CA369323277 rs1562931471	190	Y>H		No	ClinGen Ensembl
rs1585756169 CA369323280	190	Y>S		No	ClinGen Ensembl
CA4493905 rs765893405	191	L>F		No	ClinGen ExAC gnomAD
CA4493906 rs753347797	192	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA369323300 rs1307204411	193	Q>L		No	ClinGen TOPMed
COSM1448187 rs373551927 CA4493908	194	E>D	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1212032622 CA369323320	196	L>P		No	ClinGen gnomAD
rs1485178167 CA369323324	197	I>V		No	ClinGen TOPMed gnomAD
rs753011473 CA369323331	198	Q>*		No	ClinGen ExAC gnomAD
CA4493909 rs753011473	198	Q>K		No	ClinGen ExAC gnomAD
rs1585756228 CA369323340	199	Y>S		No	ClinGen Ensembl
CA369323365 rs1388322315	202	S>C		No	ClinGen TOPMed
rs1479059327 CA369323378	204	G>D		No	ClinGen TOPMed gnomAD
CA369323380 rs1479059327	204	G>V		No	ClinGen TOPMed gnomAD
rs757758746 CA4493913	207	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201852007 CA4493914	208	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4493916 rs770087364	209	A>D		No	ClinGen ExAC gnomAD
rs1414413038 CA369323404	209	A>T		No	ClinGen gnomAD
rs1374540050 CA369323415	210	Y>*		No	ClinGen gnomAD
rs1342487500 CA369323413	210	Y>C		No	ClinGen gnomAD
CA369323419 rs1431628120	211	S>C		No	ClinGen TOPMed gnomAD
rs780448658 CA4493917	211	S>I		No	ClinGen ExAC gnomAD
rs530444398 CA369323423	211	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4493919 rs771963553	213	L>R		No	ClinGen ExAC gnomAD
CA4493921 rs746951927	214	G>A		No	ClinGen ExAC gnomAD
rs772931851 CA4493920	214	G>S		No	ClinGen ExAC gnomAD
CA4493922 rs550212921	216	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	218	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4493946 rs763655379	220	W>*		No	ClinGen ExAC gnomAD
CA369323489 rs1481379459	221	A>T		No	ClinGen gnomAD
rs74623569 CA4493947	223	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs376286162 CA167016284	223	P>S		No	ClinGen ESP gnomAD
rs1233420958 CA369323518	225	D>G		No	ClinGen gnomAD
CA4493949 rs370215939	225	D>Y		No	ClinGen ESP ExAC gnomAD
CA369323528 rs1417880710	226	P>R		No	ClinGen TOPMed
rs1305551581 CA369323522	226	P>T		No	ClinGen TOPMed
COSM106309 rs141614494 CA167016319	231	D>N	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA4493954 rs754040314	232	P>H		No	ClinGen ExAC gnomAD
TCGA novel	233	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402681829 CA369323575	234	I>F		No	ClinGen TOPMed
CA167016326 rs866672883	234	I>M		No	ClinGen Ensembl
CA4493955 rs755186011	235	K>E		No	ClinGen ExAC TOPMed gnomAD
CA4493958 rs756970566	236	E>D		No	ClinGen ExAC gnomAD
rs751327014 CA4493957	236	E>V		No	ClinGen ExAC gnomAD
CA369323597 rs1165817735	237	I>N		No	ClinGen gnomAD
rs1165817735 CA369323595	237	I>T		No	ClinGen gnomAD
rs535675157 CA4493959	239	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs549613668 CA4493960	240	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA167016387 rs918591913	243	K>N		No	ClinGen TOPMed gnomAD
rs1333065534	244	T>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA167016388 rs77786363	244	T>P		No	ClinGen Ensembl
COSM1548675 rs201321507 CA4493962	245	A>T	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs768309305 CA4493964	247	Q>*		No	ClinGen ExAC gnomAD
rs61735100 CA4493966	247	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199962125 CA167016777	248	V>A		No	ClinGen 1000Genomes
rs1217959029 CA369323689	250	I>M		No	ClinGen TOPMed gnomAD
CA4494000 rs778283237	251	R>C		No	ClinGen ExAC TOPMed gnomAD
rs149850087 CA4494001	251	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs757932541 CA4494003	252	F>L		No	ClinGen ExAC gnomAD
CA4494005 rs201705302	253	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4494004 rs746697858	253	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA167016816 rs202078387	254	I>T		No	ClinGen 1000Genomes
rs554196746 CA4494007	256	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA369323728 rs746355936	257	N>D		No	ClinGen ExAC TOPMed gnomAD
rs746355936 CA4494009	257	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA4494010 rs574090393	259	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4494013 rs775372358	260	V>F		No	ClinGen ExAC TOPMed gnomAD
rs775372358 CA369323746	260	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	262	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1449369428 CA369323770	263	K>N		No	ClinGen gnomAD
CA4494015 rs200000745	265	V>M		No	ClinGen ExAC TOPMed gnomAD
rs774527077 CA4494016	266	T>K		No	ClinGen ExAC
CA369323789 rs1204053030	267	P>A		No	ClinGen TOPMed
TCGA novel	268	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142388608 CA4494018	269	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4494017 rs142388608	269	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146556418 CA4494019	269	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM370923 rs146556418 CA369323801	269	R>L	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs146556418 CA4494020	269	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	269	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4494022 rs752101060	274	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1381585380 CA369323841	275	Q>R		No	ClinGen TOPMed
rs773515819 CA369323857	276	V>I		No	ClinGen ExAC TOPMed gnomAD
rs773515819 CA4494053	276	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4494054 rs760854354	278	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1333022461 CA369323879	279	F>I		No	ClinGen TOPMed
CA369323884 rs1428077112	279	F>L		No	ClinGen TOPMed gnomAD
rs1333022461 CA369323877	279	F>V		No	ClinGen TOPMed
rs1234330238 CA369323892	280	K>N		No	ClinGen Ensembl
CA369323895 rs1429310006	281	L>*		No	ClinGen TOPMed
rs1314771281 CA369323894	281	L>M		No	ClinGen gnomAD
rs1356140056 CA369323901	282	S>G		No	ClinGen gnomAD
CA4494055 rs769617480	282	S>N		No	ClinGen ExAC gnomAD
rs1364080546 CA369323936	286	M>I		No	ClinGen gnomAD
CA4494056 rs3735042 VAR_020078	286	M>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1459825737 CA369323941	287	A>G		No	ClinGen TOPMed
rs762917699 CA4494057	287	A>T		No	ClinGen ExAC gnomAD
rs1262360285 CA369323945	288	T>A		No	ClinGen TOPMed
CA4494058 rs764135857	289	I>T		No	ClinGen ExAC gnomAD
CA369323951 rs1305353313	289	I>V		No	ClinGen gnomAD
rs751062036 CA4494059	290	L>F		No	ClinGen ExAC TOPMed gnomAD
rs751062036 CA4494060	290	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1346446776 CA369323967	291	S>R		No	ClinGen TOPMed
rs1249091012 CA369323984	294	R>G		No	ClinGen TOPMed
rs1185236820 CA369324001	296	W>R		No	ClinGen gnomAD
rs766972954 CA4494061	297	R>K		No	ClinGen ExAC gnomAD
CA4494063 rs755782533	299	C>F		No	ClinGen ExAC TOPMed gnomAD
rs750070714 CA4494062	299	C>R		No	ClinGen ExAC gnomAD
CA369324022 rs755782533	299	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs780466117 CA4494064	300	N>D		No	ClinGen ExAC TOPMed gnomAD
rs754210435 CA4494065	300	N>S		No	ClinGen ExAC TOPMed gnomAD
CA369324033 rs201074083	301	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4494068 rs201074083	301	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167409743 CA369324039	302	L>*		No	ClinGen TOPMed
rs1395012695 CA369324038	302	L>M		No	ClinGen TOPMed
rs1167409743 CA369324041	302	L>S		No	ClinGen TOPMed
CA4494070 rs779419227	303	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs572616596 CA4494071	303	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs563438026 CA4494095 COSM3698185	304	S>F	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4494096 rs781593224	305	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs746129203 CA4494097	308	E>K		No	ClinGen ExAC gnomAD
rs1471418488 CA369324101	309	D>E		No	ClinGen TOPMed gnomAD
CA369324098 rs1355629626	309	D>G		No	ClinGen TOPMed
CA167018808 rs1056397001	310	Y>H		No	ClinGen TOPMed
rs1234861201 CA369324113	311	P>R		No	ClinGen gnomAD
rs140467402 CA4494099	312	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA167018813 rs17856271 CA167018812	312	F>L		No	ClinGen ExAC TOPMed gnomAD
CA4494101 VAR_013287 rs4728329	313	N>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs4728329 CA369324120	313	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369324121 rs4728329	313	N>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4494102 rs180742689	314	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1165313370 CA369324144	316	Y>C		No	ClinGen gnomAD
rs1384899015 CA369324149	317	Y>R		No	ClinGen gnomAD

No associated diseases with O60218

2 regional properties for O60218

Type	Name	Position	InterPro Accession
domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	141 - 383	IPR002181
conserved_site	Fibrinogen, conserved site	333 - 345	IPR020837

Functions

		Description
EC Number	1.1.1.54	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Lysosome Secreted	Secreted through a lysosome-mediated non-classical pathway
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

8 GO annotations of molecular function

Name	Definition
alcohol dehydrogenase (NADP+) activity	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.
alditol:NADP+ 1-oxidoreductase activity	Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
aldo-keto reductase (NADP) activity	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
allyl-alcohol dehydrogenase activity	Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.
geranylgeranyl reductase activity	Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.
indanol dehydrogenase activity	Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+.
NADP-retinol dehydrogenase activity	Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
retinal dehydrogenase activity	Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

5 GO annotations of biological process

Name	Definition
cellular detoxification of aldehyde	Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
daunorubicin metabolic process	The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
doxorubicin metabolic process	The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
farnesol catabolic process	The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.
retinoid metabolic process	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16116	AKR1B1	Aldo-keto reductase family 1 member B1	Bos taurus (Bovine)	PR
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Homo sapiens (Human)	PR
P45376	Akr1b1	Aldo-keto reductase family 1 member B1	Mus musculus (Mouse)	PR
P45377	Akr1b8	Aldose reductase-related protein 2	Mus musculus (Mouse)	PR
P80276	AKR1B1	Aldo-keto reductase family 1 member B1	Sus scrofa (Pig)	PR
P07943	Akr1b1	Aldo-keto reductase family 1 member B1	Rattus norvegicus (Rat)	PR
Q84TF0	AKR4C10	Aldo-keto reductase family 4 member C10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M338	AKR4C11	Aldo-keto reductase family 4 member C11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0PGJ6	AKR4C9	NADPH-dependent aldo-keto reductase, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
O80944	AKR4C8	Aldo-keto reductase family 4 member C8	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MATFVELSTK	AKMPIVGLGT	WKSPLGKVKE	AVKVAIDAGY	RHIDCAYVYQ	NEHEVGEAIQ
70	80	90	100	110	120
EKIQEKAVKR	EDLFIVSKLW	PTFFERPLVR	KAFEKTLKDL	KLSYLDVYLI	HWPQGFKSGD
130	140	150	160	170	180
DLFPKDDKGN	AIGGKATFLD	AWEAMEELVD	EGLVKALGVS	NFSHFQIEKL	LNKPGLKYKP
190	200	210	220	230	240
VTNQVECHPY	LTQEKLIQYC	HSKGITVTAY	SPLGSPDRPW	AKPEDPSLLE	DPKIKEIAAK
250	260	270	280	290	300
HKKTAAQVLI	RFHIQRNVIV	IPKSVTPARI	VENIQVFDFK	LSDEEMATIL	SFNRNWRACN
310
VLQSSHLEDY	PFNAEY