AiPD: Autoinhibited Protein Database

Gene name	AKR4C9 (At2g37770, F13M22, T8P21.32)
Protein name	NADPH-dependent aldo-keto reductase, chloroplastic
Names	AtChlAKR, Aldo-keto reductase family 4 member C9
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G37770
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

173-255 (Predicted disordered autoinhibitory region) PR

173-255 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3H7U	X-ray	125 A	A	1-315	PDB
AF-Q0PGJ6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH05673381	4	A>T	No	1000Genomes
ENSVATH13564572	8	F>V	No	1000Genomes
ENSVATH01961892	9	K>E	No	1000Genomes
ENSVATH01961893	9	K>M	No	1000Genomes
ENSVATH14593938	28	P>S	No	1000Genomes
tmp_2_15834973_G_A	29	G>D	No	1000Genomes
ENSVATH00263776	33	D>G	No	1000Genomes
ENSVATH05673382	34	A>V	No	1000Genomes
tmp_2_15835163_T_C	46	I>T	No	1000Genomes
tmp_2_15835183_G_T	53	G>C	No	1000Genomes
ENSVATH13564596	82	L>V	No	1000Genomes
ENSVATH05673386	88	D>G	No	1000Genomes
ENSVATH01961918	106	E>D	No	1000Genomes
tmp_2_15835659_A_T	109	D>V	No	1000Genomes
tmp_2_15835935_C_A	133	P>T	No	1000Genomes
ENSVATH01961939	138	S>R	No	1000Genomes
tmp_2_15835958_G_A	140	W>*	No	1000Genomes
tmp_2_15835977_T_A	147	Y>N	No	1000Genomes
ENSVATH01961942	204	S>C	No	1000Genomes
tmp_2_15836299_G_A	230	V>I	No	1000Genomes
tmp_2_15836326_G_A	239	A>T	No	1000Genomes
ENSVATH01961948	248	Q>E	No	1000Genomes
ENSVATH01961949	248	Q>L	No	1000Genomes
ENSVATH13564618	258	T>I	No	1000Genomes
ENSVATH05673393	265	E>K	No	1000Genomes
tmp_2_15836422_G_T	271	D>Y	No	1000Genomes
tmp_2_15836431_A_G	274	I>V	No	1000Genomes
ENSVATH01961952	276	D>N	No	1000Genomes
ENSVATH01961953	277	Y>D	No	1000Genomes
ENSVATH01961954	282	F>L	No	1000Genomes
ENSVATH00263779	283	A>S	No	1000Genomes
tmp_2_15836603_C_T	298	H>Y	No	1000Genomes
ENSVATH05673394	313	G>A	No	1000Genomes
ENSVATH13564620	314	E>K	No	1000Genomes
tmp_2_15836656_A_G	315	I>M	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Rieske [2Fe-2S] iron-sulphur domain	70 - 165	IPR017941
domain	FAD/NAD(P)-binding domain	196 - 493	IPR023753
domain	Reductase, C-terminal	512 - 583	IPR028202

		Description
EC Number
Subcellular Localization	Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

Name	Definition
alcohol dehydrogenase (NADP+) activity	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.
alditol:NADP+ 1-oxidoreductase activity	Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
aldo-keto reductase (NADP) activity	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
NADP+ binding	Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
steroid dehydrogenase activity	Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.

Name	Definition
response to cold	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to salt stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
response to toxic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
response to water deprivation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16116	AKR1B1	Aldo-keto reductase family 1 member B1	Bos taurus (Bovine)	PR
O60218	AKR1B10	Aldo-keto reductase family 1 member B10	Homo sapiens (Human)	PR
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Homo sapiens (Human)	PR
P45376	Akr1b1	Aldo-keto reductase family 1 member B1	Mus musculus (Mouse)	PR
P45377	Akr1b8	Aldose reductase-related protein 2	Mus musculus (Mouse)	PR
P80276	AKR1B1	Aldo-keto reductase family 1 member B1	Sus scrofa (Pig)	PR
P07943	Akr1b1	Aldo-keto reductase family 1 member B1	Rattus norvegicus (Rat)	PR
Q84TF0	AKR4C10	Aldo-keto reductase family 4 member C10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M338	AKR4C11	Aldo-keto reductase family 4 member C11	Arabidopsis thaliana (Mouse-ear cress)	PR
O80944	AKR4C8	Aldo-keto reductase family 4 member C8	Arabidopsis thaliana (Mouse-ear cress)	PR