AiPD: Autoinhibited Protein Database

Gene name	AKR4C8 (At2g37760, F13M22, T8P21.6)
Protein name	Aldo-keto reductase family 4 member C8
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G37760
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

173-250 (Predicted disordered autoinhibitory region) PR

173-250 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3H7R	X-ray	140 A	A	1-311	PDB
AF-O80944-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_2_15832011_G_A	6	R>Q	No	1000Genomes
ENSVATH00263770	13	G>A	No	1000Genomes
ENSVATH05673348	17	P>H	No	1000Genomes
ENSVATH01961838	26	M>V	No	1000Genomes
tmp_2_15832077_C_T	28	A>V	No	1000Genomes
ENSVATH05673349	36	K>T	No	1000Genomes
tmp_2_15832208_C_G	42	I>M	No	1000Genomes
ENSVATH14593913	70	E>D	No	1000Genomes
ENSVATH14593925	110	H>D	No	1000Genomes
tmp_2_15832913_C_A	124	P>H	No	1000Genomes
ENSVATH05673358	141	A>P	No	1000Genomes
ENSVATH01961857	156	F>L	No	1000Genomes
ENSVATH05673359	158	S>L	No	1000Genomes
ENSVATH01961858	162	T>K	No	1000Genomes
ENSVATH14593926	169	R>H	No	1000Genomes
ENSVATH13564447	169	R>S	No	1000Genomes
tmp_2_15833092_C_G	184	Q>E	No	1000Genomes
ENSVATH05673360	185	Q>H	No	1000Genomes
tmp_2_15833270_G_T	213	V>F	No	1000Genomes
tmp_2_15833290_A_T	219	Q>H	No	1000Genomes
ENSVATH13564451	224	T>A	No	1000Genomes
ENSVATH05673364	224	T>I	No	1000Genomes
ENSVATH05673365	227	A>T	No	1000Genomes
tmp_2_15833343_T_C	237	V>A	No	1000Genomes
ENSVATH01961866	256	G>E	No	1000Genomes
ENSVATH14593928	270	I>K	No	1000Genomes
ENSVATH01961868	272	E>A	No	1000Genomes
ENSVATH01961869	276	T>A	No	1000Genomes
ENSVATH05673368	283	Q>H	No	1000Genomes

Type	Name	Position	InterPro Accession
conserved_site	Aldo/keto reductase, conserved site	38 - 55	IPR018170-1
conserved_site	Aldo/keto reductase, conserved site	139 - 156	IPR018170-2
conserved_site	Aldo/keto reductase, conserved site	250 - 265	IPR018170-3
domain	NADP-dependent oxidoreductase domain	27 - 278	IPR023210

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

Name	Definition
alditol:NADP+ 1-oxidoreductase activity	Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
aldo-keto reductase (NADP) activity	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
NADP+ binding	Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
steroid dehydrogenase activity	Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.

Name	Definition
response to cold	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to salt stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
response to toxic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
response to water deprivation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16116	AKR1B1	Aldo-keto reductase family 1 member B1	Bos taurus (Bovine)	PR
O60218	AKR1B10	Aldo-keto reductase family 1 member B10	Homo sapiens (Human)	PR
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Homo sapiens (Human)	PR
P45376	Akr1b1	Aldo-keto reductase family 1 member B1	Mus musculus (Mouse)	PR
P45377	Akr1b8	Aldose reductase-related protein 2	Mus musculus (Mouse)	PR
P80276	AKR1B1	Aldo-keto reductase family 1 member B1	Sus scrofa (Pig)	PR
P07943	Akr1b1	Aldo-keto reductase family 1 member B1	Rattus norvegicus (Rat)	PR
Q0PGJ6	AKR4C9	NADPH-dependent aldo-keto reductase, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q84TF0	AKR4C10	Aldo-keto reductase family 4 member C10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M338	AKR4C11	Aldo-keto reductase family 4 member C11	Arabidopsis thaliana (Mouse-ear cress)	PR