P80276

PR
Gene name
AKR1B1 (ALR2)
Protein name
Aldo-keto reductase family 1 member B1
Names
Aldehyde reductase, Aldose reductase, AR
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396816
EC number
1.1.1.21: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

90-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P80276

Entry ID Method Resolution Chain Position Source
1AH0 X-ray 230 A A 2-316 PDB
1AH3 X-ray 230 A A 2-316 PDB
1AH4 X-ray 200 A A 2-316 PDB
1DLA X-ray 300 A A/B/C/D 3-316 PDB
1EKO X-ray 220 A A 2-316 PDB
AF-P80276-F1 Predicted AlphaFoldDB

No variants for P80276

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P80276

No associated diseases with P80276

2 regional properties for P80276

Type Name Position InterPro Accession
domain Glycosyl transferase, family 1 288 - 446 IPR001296
domain Glycosyltransferase subfamily 4-like, N-terminal domain 75 - 245 IPR028098

Functions

Description
EC Number 1.1.1.21 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

6 GO annotations of molecular function

Name Definition
alditol:NADP+ 1-oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
allyl-alcohol dehydrogenase activity Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.
glycerol dehydrogenase [NADP+] activity Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH.
NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
prostaglandin H2 endoperoxidase reductase activity Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).
retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

1 GO annotations of biological process

Name Definition
retinoid metabolic process The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P16116 AKR1B1 Aldo-keto reductase family 1 member B1 Bos taurus (Bovine) PR
O60218 AKR1B10 Aldo-keto reductase family 1 member B10 Homo sapiens (Human) PR
P15121 AKR1B1 Aldo-keto reductase family 1 member B1 Homo sapiens (Human) PR
P45377 Akr1b8 Aldose reductase-related protein 2 Mus musculus (Mouse) PR
P45376 Akr1b1 Aldo-keto reductase family 1 member B1 Mus musculus (Mouse) PR
P07943 Akr1b1 Aldo-keto reductase family 1 member B1 Rattus norvegicus (Rat) PR
Q84TF0 AKR4C10 Aldo-keto reductase family 4 member C10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M338 AKR4C11 Aldo-keto reductase family 4 member C11 Arabidopsis thaliana (Mouse-ear cress) PR
Q0PGJ6 AKR4C9 NADPH-dependent aldo-keto reductase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
O80944 AKR4C8 Aldo-keto reductase family 4 member C8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASHLVLYTG AKMPILGLGT WKSPPGKVTE AVKVAIDLGY RHIDCAHVYQ NENEVGLGLQ
70 80 90 100 110 120
EKLQGQVVKR EDLFIVSKLW CTDHEKNLVK GACQTTLRDL KLDYLDLYLI HWPTGFKPGK
130 140 150 160 170 180
DPFPLDGDGN VVPDESDFVE TWEAMEELVD EGLVKAIGVS NFNHLQVEKI LNKPGLKYKP
190 200 210 220 230 240
AVNQIEVHPY LTQEKLIEYC KSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK
250 260 270 280 290 300
YNKTTAQVLI RFPMQRNLIV IPKSVTPERI AENFQVFDFE LSPEDMNTLL SYNRNWRVCA
310
LMSCASHKDY PFHEEY