AiPD: Autoinhibited Protein Database

P15121

Gene name	AKR1B1 (ALDR1, ALR2)
Protein name	Aldo-keto reductase family 1 member B1
Names	Aldehyde reductase, Aldose reductase, AR
Species	Homo sapiens (Human)
KEGG Pathway	hsa:231
EC number	1.1.1.21: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

182-267 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

182-267 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

173 structures for P15121

Entry ID	Method	Resolution	Chain	Position	Source
1ABN	X-ray	240 A	A	2-316	PDB
1ADS	X-ray	165 A	A	2-316	PDB
1AZ1	X-ray	180 A	A	2-316	PDB
1AZ2	X-ray	290 A	A	2-316	PDB
1EF3	X-ray	280 A	A/B	2-316	PDB
1EL3	X-ray	170 A	A	1-316	PDB
1IEI	X-ray	250 A	A	1-316	PDB
1MAR	X-ray	180 A	A	2-316	PDB
1PWL	X-ray	110 A	A	1-316	PDB
1PWM	X-ray	092 A	A	1-316	PDB
1T40	X-ray	180 A	A	1-316	PDB
1T41	X-ray	105 A	A	1-316	PDB
1US0	X-ray	066 A	A	1-316	PDB
1X96	X-ray	140 A	A	1-316	PDB
1X97	X-ray	140 A	A	1-316	PDB
1X98	X-ray	130 A	A	1-316	PDB
1XGD	X-ray	210 A	A	2-316	PDB
1Z3N	X-ray	104 A	A	1-316	PDB
1Z89	X-ray	143 A	A	1-316	PDB
1Z8A	X-ray	095 A	A	1-316	PDB
2ACQ	X-ray	176 A	A	2-316	PDB
2ACR	X-ray	176 A	A	2-316	PDB
2ACS	X-ray	176 A	A	2-316	PDB
2ACU	X-ray	176 A	A	2-316	PDB
2AGT	X-ray	100 A	A	1-316	PDB
2DUX	X-ray	160 A	A	1-316	PDB
2DUZ	X-ray	160 A	A	1-316	PDB
2DV0	X-ray	162 A	A	1-316	PDB
2F2K	X-ray	194 A	A	1-316	PDB
2FZ8	X-ray	148 A	A	1-316	PDB
2FZ9	X-ray	160 A	A	1-316	PDB
2FZB	X-ray	150 A	A	6-316	PDB
2FZD	X-ray	108 A	A	6-316	PDB
2HV5	X-ray	159 A	A	1-316	PDB
2HVN	X-ray	158 A	A	1-316	PDB
2HVO	X-ray	165 A	A	1-316	PDB
2I16	X-ray	081 A	A	1-316	PDB
2I17	X-ray	081 A	A	1-316	PDB
2IKG	X-ray	143 A	A	1-316	PDB
2IKH	X-ray	155 A	A	1-316	PDB
2IKI	X-ray	147 A	A	1-316	PDB
2IKJ	X-ray	155 A	A	1-316	PDB
2INE	X-ray	190 A	A	2-316	PDB
2INZ	X-ray	195 A	A	2-316	PDB
2IPW	X-ray	200 A	A	2-316	PDB
2IQ0	X-ray	195 A	A	2-316	PDB
2IQD	X-ray	200 A	A	2-316	PDB
2IS7	X-ray	170 A	A	2-316	PDB
2ISF	X-ray	200 A	A	2-316	PDB
2J8T	X-ray	082 A	A	6-316	PDB
2NVC	X-ray	165 A	A	1-316	PDB
2NVD	X-ray	155 A	A	1-316	PDB
2PD5	X-ray	160 A	A	1-316	PDB
2PD9	X-ray	155 A	A	1-316	PDB
2PDB	X-ray	160 A	A	1-316	PDB
2PDC	X-ray	165 A	A	1-316	PDB
2PDF	X-ray	156 A	A	1-316	PDB
2PDG	X-ray	142 A	A	1-316	PDB
2PDH	X-ray	145 A	A	1-316	PDB
2PDI	X-ray	155 A	A	1-316	PDB
2PDJ	X-ray	157 A	A	1-316	PDB
2PDK	X-ray	155 A	A	1-316	PDB
2PDL	X-ray	147 A	A	1-316	PDB
2PDM	X-ray	175 A	A	1-316	PDB
2PDN	X-ray	170 A	A	1-316	PDB
2PDP	X-ray	165 A	A	1-316	PDB
2PDQ	X-ray	173 A	A	1-316	PDB
2PDU	X-ray	155 A	A	1-316	PDB
2PDW	X-ray	155 A	A	1-316	PDB
2PDX	X-ray	165 A	A	1-316	PDB
2PDY	X-ray	165 A	A	1-316	PDB
2PEV	X-ray	090 A	A	1-316	PDB
2PF8	X-ray	085 A	A	1-316	PDB
2PFH	X-ray	085 A	A	1-316	PDB
2PZN	X-ray	100 A	A	1-316	PDB
2QXW	X-ray	080 A	A	1-316	PDB
2R24	X-ray	175 A	A	1-316	PDB
3BCJ	X-ray	078 A	A	1-316	PDB
3DN5	X-ray	145 A	A	1-316	PDB
3G5E	X-ray	180 A	A	1-316	PDB
3GHR	X-ray	100 A	A	1-316	PDB
3GHS	X-ray	100 A	A	1-316	PDB
3GHT	X-ray	110 A	A	1-316	PDB
3GHU	X-ray	120 A	A	1-316	PDB
3LBO	X-ray	110 A	A	1-316	PDB
3LD5	X-ray	127 A	A	1-316	PDB
3LEN	X-ray	121 A	A	1-316	PDB
3LEP	X-ray	099 A	A	1-316	PDB
3LQG	X-ray	135 A	A	1-316	PDB
3LQL	X-ray	113 A	A	1-316	PDB
3LZ3	X-ray	103 A	A	1-316	PDB
3LZ5	X-ray	095 A	A	1-316	PDB
3M0I	X-ray	107 A	A	1-316	PDB
3M4H	X-ray	094 A	A	1-316	PDB
3M64	X-ray	130 A	A	1-316	PDB
3MB9	X-ray	165 A	A	1-316	PDB
3MC5	X-ray	114 A	A	1-316	PDB
3ONB	X-ray	145 A	A	2-316	PDB
3ONC	X-ray	106 A	A	2-316	PDB
3P2V	X-ray	169 A	A	1-316	PDB
3Q65	X-ray	209 A	A/B	1-316	PDB
3Q67	X-ray	155 A	A/B	1-316	PDB
3RX2	X-ray	190 A	A	1-316	PDB
3RX3	X-ray	190 A	A	1-316	PDB
3RX4	X-ray	200 A	A	1-316	PDB
3S3G	X-ray	180 A	A	1-316	PDB
3T42	X-ray	128 A	A	1-316	PDB
3U2C	X-ray	100 A	A	1-316	PDB
3V35	X-ray	190 A	A	1-316	PDB
3V36	X-ray	200 A	A	1-316	PDB
4GCA	X-ray	090 A	A	2-316	PDB
4GQ0	X-ray	210 A	A	1-316	PDB
4IGS	X-ray	085 A	A	1-316	PDB
4JIR	X-ray	200 A	A	1-316	PDB
4LAU	X-ray	084 A	A	1-316	PDB
4LAZ	X-ray	085 A	A	1-316	PDB
4LB3	X-ray	080 A	A	1-316	PDB
4LB4	X-ray	080 A	A	1-316	PDB
4LBR	X-ray	080 A	A	1-316	PDB
4LBS	X-ray	076 A	A	1-316	PDB
4NKC	X-ray	112 A	A	2-316	PDB
4PR4	X-ray	106 A	A	2-316	PDB
4PRR	X-ray	101 A	A	2-316	PDB
4PRT	X-ray	096 A	A	1-316	PDB
4PUU	X-ray	114 A	A	1-316	PDB
4PUW	X-ray	112 A	A	1-316	PDB
4Q7B	X-ray	119 A	A	2-316	PDB
4QBX	X-ray	098 A	A	1-316	PDB
4QR6	X-ray	105 A	A	1-316	PDB
4QX4	X-ray	126 A	A	1-316	PDB
4QXI	X-ray	087 A	A	1-316	PDB
4RPQ	X-ray	120 A	A	2-316	PDB
4XZH	X-ray	100 A	A/B	1-316	PDB
4XZI	X-ray	245 A	A	1-316	PDB
4YS1	X-ray	107 A	A	1-316	PDB
4YU1	X-ray	102 A	A	1-316	PDB
5HA7	X-ray	165 A	A/B	1-316	PDB
5OU0	X-ray	094 A	A	1-316	PDB
5OUJ	X-ray	096 A	A	1-316	PDB
5OUK	X-ray	096 A	A	1-316	PDB
6F7R	X-ray	092 A	A	1-316	PDB
6F81	X-ray	097 A	A	1-316	PDB
6F82	X-ray	103 A	A	1-316	PDB
6F84	X-ray	109 A	A	1-316	PDB
6F8O	X-ray	117 A	A	1-316	PDB
6SYW	X-ray	093 A	A	1-316	PDB
6T27	X-ray	111 A	A	1-316	PDB
6T3P	X-ray	097 A	A	1-316	PDB
6T5G	X-ray	128 A	A	1-316	PDB
6T7Q	X-ray	101 A	A	1-316	PDB
6TD8	X-ray	097 A	A	1-316	PDB
6TUC	X-ray	106 A	A	1-316	PDB
6TUF	X-ray	115 A	A	1-316	PDB
6TXP	X-ray	095 A	A	1-316	PDB
6XUM	X-ray	097 A	A	1-316	PDB
6Y03	X-ray	169 A	A	1-316	PDB
6Y1P	X-ray	094 A	A	1-316	PDB
8A4N	X-ray	093 A	A	1-316	PDB
8AE9	X-ray	095 A	A	1-316	PDB
8AQG	X-ray	095 A	A	1-313	PDB
8AQP	X-ray	096 A	A	1-316	PDB
8AUU	X-ray	095 A	A	1-316	PDB
8B34	X-ray	097 A	A	1-316	PDB
8B3N	X-ray	103 A	A	1-316	PDB
8B3R	X-ray	096 A	A	1-316	PDB
8B66	X-ray	095 A	A	1-316	PDB
8BJL	X-ray	097 A	A	1-316	PDB
8FH5	X-ray	162 A	A	2-316	PDB
8FH6	X-ray	195 A	A	1-316	PDB
8FH7	X-ray	145 A	A	1-316	PDB
8FH8	X-ray	160 A	A	1-316	PDB
8FH9	X-ray	170 A	A	1-316	PDB
AF-P15121-F1	Predicted				AlphaFoldDB

252 variants for P15121

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1227903553	1	M>?	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA369321969 rs776171717	2	A>E		No	ClinGen ExAC TOPMed gnomAD
rs749387574 CA167003447	2	A>T		No	ClinGen Ensembl
CA4493610 rs776171717	2	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4493609 rs770560951	3	S>G		No	ClinGen ExAC gnomAD
TCGA novel	3	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369321961 rs772775959	4	R>C		No	ClinGen ExAC TOPMed gnomAD
CA167003436 rs772775959	4	R>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	4	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4493607 rs772775959	4	R>S		No	ClinGen ExAC TOPMed gnomAD
CA4493606 rs772045888	5	L>F		No	ClinGen ExAC gnomAD
rs1286167481 CA369321955	5	L>H		No	ClinGen gnomAD
rs1019342899 CA167003430	6	L>Q		No	ClinGen Ensembl
rs754789251 CA4493603	9	N>S		No	ClinGen ExAC TOPMed gnomAD
rs577826776 CA4493602	10	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1379579977 CA369321926	10	G>R		No	ClinGen gnomAD
CA369321927 rs1379579977	10	G>S		No	ClinGen gnomAD
rs757493252 CA4493600	11	A>G		No	ClinGen ExAC gnomAD
CA4493599 rs751652725	12	K>E		No	ClinGen ExAC gnomAD
CA369321902 CA369321904 rs1490571862	13	M>I		No	ClinGen gnomAD
rs1294495813 CA369321896	14	P>L		No	ClinGen gnomAD
rs5054 CA167003421 VAR_014743	15	I>F		No	ClinGen UniProt TOPMed dbSNP gnomAD
rs759016088 CA4493597	15	I>N		No	ClinGen ExAC gnomAD
rs5054 CA369321894	15	I>V		No	ClinGen TOPMed gnomAD
CA369321881 rs1392886142	17	G>A		No	ClinGen TOPMed
CA4493596 rs143744154	18	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	19	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759994468 CA4493594	20	T>A		No	ClinGen ExAC TOPMed gnomAD
CA369321866 rs759994468	20	T>S		No	ClinGen ExAC TOPMed gnomAD
CA369321050 rs1292342051	24	P>L		No	ClinGen TOPMed gnomAD
rs1376636728 CA369321039	26	G>E		No	ClinGen gnomAD
rs1462112449 CA369321035	27	Q>*		No	ClinGen TOPMed
rs773845040 CA4493570	27	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA4493569 rs555243165	28	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA369321024 rs1408411023	29	T>A		No	ClinGen gnomAD
rs371350653 CA4493568	29	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs764315032 CA4493564	32	V>M		No	ClinGen ExAC gnomAD
CA369320979 rs1422453741	36	I>V		No	ClinGen gnomAD
rs748304576 CA4493562	38	V>I		No	ClinGen ExAC TOPMed gnomAD
rs754399252 CA4493559	39	G>A		No	ClinGen ExAC TOPMed gnomAD
CA4493560 rs201718247	39	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1585715092 CA369320951	40	Y>S		No	ClinGen Ensembl
rs200105058 CA4493558	41	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369320946 rs1229108905	41	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA167001198 rs5056 VAR_014744	42	H>L		No	ClinGen UniProt Ensembl dbSNP
rs1314041501 CA369320941	42	H>Y		No	ClinGen TOPMed gnomAD
CA167001192 rs996513111	43	I>V		No	ClinGen TOPMed
rs1485185263 CA369320927	44	D>A		No	ClinGen TOPMed
CA369320929 rs1329437875	44	D>N		No	ClinGen gnomAD
CA369320913 rs1185528972	46	A>T		No	ClinGen TOPMed
rs1390867326 CA369320909	46	A>V		No	ClinGen gnomAD
CA369320903 rs1397237724	47	H>P		No	ClinGen gnomAD
CA167001187 rs892828323	47	H>Q		No	ClinGen Ensembl
TCGA novel	48	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369320875 rs1429030704	51	N>S		No	ClinGen TOPMed
rs1370806069 CA369320858	53	N>K		No	ClinGen TOPMed
rs751115722 CA4493553	53	N>S		No	ClinGen ExAC TOPMed gnomAD
CA167001172 rs934410375	54	E>D		No	ClinGen Ensembl
rs553878004 CA4493552	56	G>A		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	56	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369320835 rs1436218117	57	V>A		No	ClinGen TOPMed
CA167001166 rs903328570	57	V>L		No	ClinGen Ensembl
rs775523523 CA4493549	58	A>S		No	ClinGen ExAC gnomAD
rs1464196240 CA369320827	59	I>V		No	ClinGen Ensembl
TCGA novel	61	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769563589 CA4493548	61	E>K		No	ClinGen ExAC gnomAD
CA369320813 rs769563589	61	E>Q		No	ClinGen ExAC gnomAD
rs903237372 CA167001156	64	R>G		No	ClinGen TOPMed gnomAD
rs1436755087 CA369320783	65	E>G		No	ClinGen gnomAD
CA369320774 rs1376445662	66	Q>R		No	ClinGen TOPMed
rs772483114 CA4493545	67	V>A		No	ClinGen ExAC gnomAD
CA4493546 rs776564021	67	V>M		No	ClinGen ExAC gnomAD
rs768801970 CA4493542	69	K>*		No	ClinGen ExAC
rs749268678 CA369320755 CA4493541	69	K>N		No	ClinGen ExAC TOPMed gnomAD
CA369320757 rs1246402712	69	K>R		No	ClinGen TOPMed gnomAD
rs780615158 CA4493540 COSM238747	70	R>C	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4493539 rs756570400	70	R>H		No	ClinGen ExAC TOPMed gnomAD
CA369320751 rs756570400	70	R>L		No	ClinGen ExAC TOPMed gnomAD
rs781510920 CA4493537	72	E>A		No	ClinGen ExAC TOPMed gnomAD
rs11544686 CA167001126	72	E>D		No	ClinGen TOPMed
CA4493538 rs781510920	72	E>G		No	ClinGen ExAC TOPMed gnomAD
rs5057 VAR_014745 CA167001124	73	L>V		No	ClinGen UniProt Ensembl dbSNP
CA4493535 rs751246702	76	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4493491 rs754547262	82	T>M		No	ClinGen ExAC TOPMed gnomAD
CA369320658 rs754547262	82	T>R		No	ClinGen ExAC TOPMed gnomAD
CA167000819 rs1036613744	83	Y>N		No	ClinGen Ensembl
CA4493489 rs780206909	84	H>R		No	ClinGen ExAC gnomAD
CA4493488 VAR_048213 rs2229542	90	K>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs890428946 CA167000810	91	G>R		No	ClinGen Ensembl
CA369320587 rs1341776306	93	C>F		No	ClinGen TOPMed
rs767183202 CA4493486	94	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA167000800 rs932031834	95	K>N		No	ClinGen gnomAD
rs148084524 CA4493485	97	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs143736441 CA167000789	98	S>G		No	ClinGen ESP TOPMed
rs116793843 CA369320554	98	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4493482 rs765362829	99	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4493481 rs374068972	100	L>M		No	ClinGen ESP ExAC gnomAD
rs761065461 CA4493479	101	K>E		No	ClinGen ExAC gnomAD
CA167000777 rs755435675	102	L>R		No	ClinGen Ensembl
rs115638419 CA4493477	103	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1470382501 CA369320502	107	L>I		No	ClinGen TOPMed gnomAD
rs200955767 CA167000768	108	Y>C		No	ClinGen 1000Genomes
rs754080850 CA4493475	109	L>F		No	ClinGen ExAC TOPMed gnomAD
CA167000763 rs754080850	109	L>V		No	ClinGen ExAC TOPMed gnomAD
CA369320475 rs1161442982	110	I>T		No	ClinGen gnomAD
rs768419303 CA4493473 COSM69608	113	P>L	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1395921638 CA369320428	115	G>S		No	ClinGen TOPMed
CA369319930 rs1341068342	118	P>S		No	ClinGen TOPMed
CA4493452 rs145091628	120	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs267601301 CA167000430	124	P>L		No	ClinGen Ensembl
rs1403878780 CA369319863	124	P>S		No	ClinGen gnomAD
CA4493451 rs371173126	128	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	129	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146644885 CA4493449	129	G>S		No	ClinGen ESP ExAC gnomAD
rs373907248 CA369319793	130	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373907248 CA4493448	130	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1047476538 CA167000418	132	V>A		No	ClinGen TOPMed
CA369319765 rs746868477	133	P>H		No	ClinGen ExAC TOPMed gnomAD
rs746868477 CA4493447	133	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	134	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4493446 rs777521530	137	N>D		No	ClinGen ExAC gnomAD
TCGA novel	139	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755234075 CA369319680	140	D>E		No	ClinGen ExAC gnomAD
CA4493443 rs766541770	141	T>M		No	ClinGen ExAC TOPMed gnomAD
rs754091936 CA4493444	141	T>S		No	ClinGen ExAC gnomAD
TCGA novel	142	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs17856148 CA167000400	142	W>R		No	ClinGen Ensembl
rs567860325 CA167000397	143	A>T		No	ClinGen 1000Genomes
CA4493441 rs750511168	143	A>V		No	ClinGen ExAC TOPMed gnomAD
CA369319556 rs1361125949	144	A>T		No	ClinGen Ensembl
CA369319547 CA4493414 rs770505903	145	M>L		No	ClinGen ExAC TOPMed gnomAD
CA4493413 rs770505903	145	M>V		No	ClinGen ExAC TOPMed gnomAD
CA4493412 rs760130465	147	E>K		No	ClinGen ExAC gnomAD
CA369319495 rs1170869525	149	V>L		No	ClinGen gnomAD
rs773147883 CA4493411	150	D>V		No	ClinGen ExAC TOPMed gnomAD
rs771990751 CA4493410	151	E>K		No	ClinGen ExAC gnomAD
rs1023543431 CA166999960	152	G>R		No	ClinGen TOPMed gnomAD
rs1312968929 CA369319440	154	V>L		No	ClinGen gnomAD
rs1270285190 CA369319416	156	A>S		No	ClinGen TOPMed
rs747992861 CA4493409	156	A>V		No	ClinGen ExAC gnomAD
CA4493408 rs778745784	158	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1480104657 CA369319370	160	S>Y		No	ClinGen gnomAD
CA166999946 rs367750648	164	H>R		No	ClinGen ESP TOPMed
rs1419904939 CA369319271	168	E>D		No	ClinGen TOPMed
rs1207008888 CA369319266	169	M>T		No	ClinGen gnomAD
CA166999938 rs1003776570	171	L>S		No	ClinGen Ensembl
rs11544687 CA166999929	174	P>L		No	ClinGen Ensembl
CA166999934 rs905427503	174	P>S		No	ClinGen gnomAD
CA166999931 rs905427503	174	P>T		No	ClinGen gnomAD
CA4493402 rs757422740	175	G>D		No	ClinGen ExAC TOPMed gnomAD
CA369319207 rs1310289314	178	Y>H		No	ClinGen gnomAD
CA4493399 rs758962979	179	K>E		No	ClinGen ExAC gnomAD
CA369319181 rs1164777704	182	V>I		No	ClinGen TOPMed gnomAD
TCGA novel rs765608056 CA4493397	183	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
rs1402962430 CA369319165	184	Q>P		No	ClinGen TOPMed
rs1470875799 CA369319133	187	C>S		No	ClinGen TOPMed
rs944534411 CA166999738	188	H>N		No	ClinGen Ensembl
rs755384865 CA4493376	189	P>Q		No	ClinGen ExAC gnomAD
CA369319077 rs1562907046	195	K>E		No	ClinGen Ensembl
CA4493372 rs755740371	200	C>F		No	ClinGen ExAC gnomAD
rs767044900 CA4493370	201	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs749975265 CA4493371	201	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs946646731 CA166999721	202	S>C		No	ClinGen gnomAD
CA369319018 rs1585710996	203	K>R		No	ClinGen Ensembl
VAR_014746 rs5061 CA166999719	204	G>S		No	ClinGen UniProt Ensembl dbSNP
CA4493368 rs201899655	206	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs763868392 CA4493367	207	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4493365 rs775137066	209	A>T		No	ClinGen ExAC gnomAD
rs1325010981 CA369318982	209	A>V		No	ClinGen gnomAD
rs756616387 CA4493364	210	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA166999700 rs746316716	211	S>G		No	ClinGen Ensembl
rs1321971782 CA369318953	214	G>C		No	ClinGen TOPMed gnomAD
rs1321971782 CA369318955	214	G>S		No	ClinGen TOPMed gnomAD
rs1467939858 CA369318947	215	S>A		No	ClinGen gnomAD
rs1428133282 CA369318942	216	P>A		No	ClinGen gnomAD
CA369318929 rs1181863874	218	R>G		No	ClinGen TOPMed
rs772301030 CA4493361	219	P>S		No	ClinGen ExAC gnomAD
CA4493360 rs748119899	220	W>S		No	ClinGen ExAC TOPMed gnomAD
rs1449861244 CA369318896	221	A>S		No	ClinGen gnomAD
rs1449861244 CA369318898	221	A>T		No	ClinGen gnomAD
CA369318881 rs1327710888	223	P>H		No	ClinGen gnomAD
TCGA novel	223	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757886145 CA4493330	224	E>G		No	ClinGen ExAC TOPMed gnomAD
CA4493331 rs777117648	224	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1585710433 CA369318869	225	D>A		No	ClinGen Ensembl
CA4493329 rs752703695	225	D>E		No	ClinGen ExAC gnomAD
rs765212760 CA4493328	226	P>A		No	ClinGen ExAC gnomAD
rs200903070 CA4493327	226	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1232540536 CA369318856	227	S>F		No	ClinGen gnomAD
CA369318861 rs1468838236	227	S>P		No	ClinGen gnomAD
rs151130700 CA166999552	228	L>H		No	ClinGen ESP TOPMed
rs151130700 CA369318853	228	L>P		No	ClinGen ESP TOPMed
CA4493326 rs753684976	228	L>V		No	ClinGen ExAC gnomAD
rs1484242051 CA369318845	230	E>Q		No	ClinGen gnomAD
CA369318838 rs1222473564	231	D>N		No	ClinGen gnomAD
rs199858307 CA4493323	236	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA166999540 rs762963189	237	I>M		No	ClinGen ExAC TOPMed gnomAD
rs768636967 CA4493321	237	I>V		No	ClinGen ExAC gnomAD
CA4493319 rs770279911	238	A>S		No	ClinGen ExAC TOPMed gnomAD
CA4493318 rs770279911 COSM204342	238	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4493317 rs746287907	239	A>P		No	ClinGen ExAC gnomAD
CA4493315 rs753491056	241	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1378323150 CA369318764	242	N>S		No	ClinGen TOPMed
rs1585710275 CA369318756	243	K>R		No	ClinGen Ensembl
CA4493314 rs368616250	244	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA369318742 rs1399057016	245	T>I		No	ClinGen gnomAD
CA369318738 rs1562906624	246	A>G		No	ClinGen Ensembl
rs1407261115 CA369318741	246	A>T		No	ClinGen gnomAD
TCGA novel	248	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369318702 rs1585709662	250	I>N		No	ClinGen Ensembl
CA4493284 rs145261078	251	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4493285 rs752815623	251	R>W		No	ClinGen ExAC TOPMed gnomAD
rs759564198 CA4493283	254	M>T		No	ClinGen ExAC gnomAD
rs777017519 CA4493282	255	Q>*		No	ClinGen ExAC gnomAD
CA4493281 rs766847306	256	R>G		No	ClinGen ExAC gnomAD
rs139647493 CA4493280	256	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4493279 rs773615800	258	L>F		No	ClinGen ExAC gnomAD
CA369318643 rs1257585858	259	V>G		No	ClinGen gnomAD
rs1483371908 CA369318646	259	V>L		No	ClinGen TOPMed gnomAD
rs201921941 CA4493278	263	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA4493277 rs147442012	268	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369318583 rs1230446062	269	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM204341 CA369318581 rs1380748552	269	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	272	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748760893 CA4493274	274	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1472056924 CA369318238	276	V>A		No	ClinGen gnomAD
rs768419190 CA4493252	278	D>H		No	ClinGen ExAC gnomAD
CA4493251 rs762426984	279	F>I		No	ClinGen ExAC gnomAD
rs995091941 CA369318155	283	S>R		No	ClinGen gnomAD
rs755585273 CA166998612	284	Q>H		No	ClinGen TOPMed gnomAD
CA4493249 rs750121058	285	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	286	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_014747 rs5062 CA4493248	288	T>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs770727307 CA4493245	292	Y>H		No	ClinGen ExAC gnomAD
CA4493244 rs201721722	296	W>C		No	ClinGen 1000Genomes ExAC gnomAD
CA4493243 rs779176563	299	C>S		No	ClinGen ExAC gnomAD
rs755184764 CA369318033	300	A>G		No	ClinGen ExAC gnomAD
rs755184764 CA4493242	300	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs749559219 CA4493218	304	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1348439607 CA369317991	305	T>A		No	ClinGen TOPMed
CA369317990 rs1348439607	305	T>P		No	ClinGen TOPMed
rs1040268676 CA166997772	308	K>M		No	ClinGen Ensembl
CA369317946 rs1442026734	311	P>S		No	ClinGen gnomAD
CA4493215 rs781778959	313	H>L		No	ClinGen ExAC gnomAD
CA369317931 rs781778959	313	H>P		No	ClinGen ExAC gnomAD
CA4493214 rs781778959	313	H>R		No	ClinGen ExAC gnomAD
CA4493213 rs757815855	314	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	315	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1274552433 CA369317917	315	E>G		No	ClinGen gnomAD
CA166997758 rs764619605	316	F>C		No	ClinGen gnomAD
CA4493212 rs752010122	316	F>I		No	ClinGen ExAC gnomAD
CA4493211 rs764583222	317	F>R		No	ClinGen ExAC gnomAD

No associated diseases with P15121

4 regional properties for P15121

Type	Name	Position	InterPro Accession
conserved_site	Aldo/keto reductase, conserved site	39 - 56	IPR018170-1
conserved_site	Aldo/keto reductase, conserved site	145 - 162	IPR018170-2
conserved_site	Aldo/keto reductase, conserved site	261 - 276	IPR018170-3
domain	NADP-dependent oxidoreductase domain	16 - 289	IPR023210

Functions

		Description
EC Number	1.1.1.21	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

8 GO annotations of molecular function

Name	Definition
alditol:NADP+ 1-oxidoreductase activity	Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
allyl-alcohol dehydrogenase activity	Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.
electron transfer activity	Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
glyceraldehyde oxidoreductase activity	Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+).
glycerol dehydrogenase [NADP+] activity	Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH.
NADP-retinol dehydrogenase activity	Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
prostaglandin H2 endoperoxidase reductase activity	Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).
retinal dehydrogenase activity	Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

12 GO annotations of biological process

Name	Definition
C21-steroid hormone biosynthetic process	The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cellular hyperosmotic salinity response	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
daunorubicin metabolic process	The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
doxorubicin metabolic process	The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
epithelial cell maturation	The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
fructose biosynthetic process	The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.
metanephric collecting duct development	The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
regulation of urine volume	Any process that modulates the amount of urine excreted from the body over a unit of time.
renal water homeostasis	Renal process involved in the maintenance of an internal steady state of water in the body.
retinoid metabolic process	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16116	AKR1B1	Aldo-keto reductase family 1 member B1	Bos taurus (Bovine)	PR
O60218	AKR1B10	Aldo-keto reductase family 1 member B10	Homo sapiens (Human)	PR
P45377	Akr1b8	Aldose reductase-related protein 2	Mus musculus (Mouse)	PR
P45376	Akr1b1	Aldo-keto reductase family 1 member B1	Mus musculus (Mouse)	PR
P80276	AKR1B1	Aldo-keto reductase family 1 member B1	Sus scrofa (Pig)	PR
P07943	Akr1b1	Aldo-keto reductase family 1 member B1	Rattus norvegicus (Rat)	PR
Q84TF0	AKR4C10	Aldo-keto reductase family 4 member C10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M338	AKR4C11	Aldo-keto reductase family 4 member C11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0PGJ6	AKR4C9	NADPH-dependent aldo-keto reductase, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
O80944	AKR4C8	Aldo-keto reductase family 4 member C8	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MASRLLLNNG	AKMPILGLGT	WKSPPGQVTE	AVKVAIDVGY	RHIDCAHVYQ	NENEVGVAIQ
70	80	90	100	110	120
EKLREQVVKR	EELFIVSKLW	CTYHEKGLVK	GACQKTLSDL	KLDYLDLYLI	HWPTGFKPGK
130	140	150	160	170	180
EFFPLDESGN	VVPSDTNILD	TWAAMEELVD	EGLVKAIGIS	NFNHLQVEMI	LNKPGLKYKP
190	200	210	220	230	240
AVNQIECHPY	LTQEKLIQYC	QSKGIVVTAY	SPLGSPDRPW	AKPEDPSLLE	DPRIKAIAAK
250	260	270	280	290	300
HNKTTAQVLI	RFPMQRNLVV	IPKSVTPERI	AENFKVFDFE	LSSQDMTTLL	SYNRNWRVCA
310
LLSCTSHKDY	PFHEEF