P45377
PR
Gene name |
Akr1b8 (Fgfrp) |
Protein name |
Aldose reductase-related protein 2 |
Names |
AR, Aldehyde reductase, Fibroblast growth factor-regulated protein, Protein FR-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14187 |
EC number |
1.1.1.21: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P45377
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1FRB | X-ray | 170 A | A | 2-316 | PDB |
| AF-P45377-F1 | Predicted | AlphaFoldDB |
23 variants for P45377
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3396678669 | 4 | F>I | No | EVA | |
| rs3388816505 | 17 | G>C | No | EVA | |
| rs3388814994 | 36 | I>F | No | EVA | |
| rs585048019 | 69 | Q>K | No | EVA | |
| rs3388805718 | 106 | D>G | No | EVA | |
| rs3388814542 | 146 | E>G | No | EVA | |
| rs37187587 | 159 | V>I | No | EVA | |
| rs3388822942 | 161 | N>D | No | EVA | |
| rs231075541 | 206 | S>T | No | EVA | |
| rs217666289 | 207 | V>I | No | EVA | |
| rs3388814541 | 213 | L>Q | No | EVA | |
| rs3388814986 | 217 | D>H | No | EVA | |
| rs583190156 | 229 | L>V | No | EVA | |
| rs36267008 | 233 | K>R | No | EVA | |
| rs225357632 | 242 | E>K | No | EVA | |
| rs3388821553 | 257 | N>I | No | EVA | |
| rs3388808296 | 259 | V>A | No | EVA | |
| rs3396465586 | 276 | V>A | No | EVA | |
| rs3396693602 | 276 | V>L | No | EVA | |
| rs585114148 | 284 | E>K | No | EVA | |
| rs3396678696 | 292 | F>L | No | EVA | |
| rs3388823992 | 307 | M>K | No | EVA | |
| rs580288184 | 307 | M>L | No | EVA |
No associated diseases with P45377
1 regional properties for P45377
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal | 40 - 621 | IPR002553 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.21 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| alcohol dehydrogenase (NADP+) activity | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. |
| alditol:NADP+ 1-oxidoreductase activity | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
| estradiol 17-beta-dehydrogenase activity | Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. |
| geranylgeranyl reductase activity | Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. |
| indanol dehydrogenase activity | Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. |
| NADP+ binding | Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| NADP-retinol dehydrogenase activity | Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. |
| NADPH binding | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| retinal binding | Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. |
| retinal dehydrogenase activity | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| polyol metabolic process | The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. |
| retinal metabolic process | The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16116 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Bos taurus (Bovine) | PR |
| P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Homo sapiens (Human) | PR |
| O60218 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Homo sapiens (Human) | PR |
| P45376 | Akr1b1 | Aldo-keto reductase family 1 member B1 | Mus musculus (Mouse) | PR |
| P80276 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Sus scrofa (Pig) | PR |
| P07943 | Akr1b1 | Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Rat) | PR |
| Q84TF0 | AKR4C10 | Aldo-keto reductase family 4 member C10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M338 | AKR4C11 | Aldo-keto reductase family 4 member C11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0PGJ6 | AKR4C9 | NADPH-dependent aldo-keto reductase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80944 | AKR4C8 | Aldo-keto reductase family 4 member C8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATFVELSTK | AKMPIVGLGT | WKSPPNQVKE | AVKAAIDAGY | RHIDCAYAYC | NENEVGEAIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKIKEKAVQR | EDLFIVSKLW | PTCFEKKLLK | EAFQKTLTDL | KLDYLDLYLI | HWPQGLQPGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELFPKDDQGR | ILTSKTTFLE | AWEGMEELVD | QGLVKALGVS | NFNHFQIERL | LNKPGLKHKP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTNQVECHPY | LTQEKLIQYC | HSKGISVTAY | SPLGSPDRPS | AKPEDPSLLE | DPKIKEIAAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HEKTSAQVLI | RFHIQRNVVV | IPKSVTPSRI | QENIQVFDFQ | LSDEEMATIL | SFNRNWRACL |
| 310 | |||||
| LPETVNMEEY | PYDAEY |