AiPD: Autoinhibited Protein Database

Gene name	TPR2 (At3g16830, K20I9.6)
Protein name	Topless-related protein 2
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G16830
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

217-311 (Predicted disordered autoinhibitory region) PR

217-311 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LRZ0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH10727998	23	E>A	No	1000Genomes
tmp_3_5731908_A_G	39	K>E	No	1000Genomes
tmp_3_5731940_G_T	49	E>D	No	1000Genomes
tmp_3_5732898_A_T	256	M>L	No	1000Genomes
ENSVATH02154049	268	G>S	No	1000Genomes
tmp_3_5732941_T_C	270	V>A	No	1000Genomes
ENSVATH05846509	287	H>R	No	1000Genomes
ENSVATH02154051	324	P>S	No	1000Genomes
tmp_3_5733425_C_T	345	R>C	No	1000Genomes
ENSVATH05846516	387	P>L	No	1000Genomes
tmp_3_5733861_C_T	403	S>F	No	1000Genomes
tmp_3_5734355_G_A	483	D>N	No	1000Genomes
ENSVATH10728058	583	L>S	No	1000Genomes
ENSVATH13932919	593	V>I	No	1000Genomes
ENSVATH00327930	672	A>V	No	1000Genomes
ENSVATH10728060	690	A>T	No	1000Genomes
ENSVATH00327931	692	A>T	No	1000Genomes
ENSVATH10728061	701	K>N	No	1000Genomes
ENSVATH00327933	723	M>I	No	1000Genomes
ENSVATH00327934	738	K>M	No	1000Genomes
ENSVATH13932920	741	P>L	No	1000Genomes
ENSVATH10728087	833	S>T	No	1000Genomes
ENSVATH13932921	835	P>L	No	1000Genomes
ENSVATH10728121	944	A>S	No	1000Genomes
tmp_3_5736797_C_T	946	S>L	No	1000Genomes
tmp_3_5736803_A_G	948	E>G	No	1000Genomes
tmp_3_5736828_G_T	956	Q>H	No	1000Genomes
ENSVATH05846545	968	R>G	No	1000Genomes
tmp_3_5736932_C_G	991	A>G	No	1000Genomes
tmp_3_5736949_A_G	997	I>V	No	1000Genomes
ENSVATH13932945	1033	V>L	No	1000Genomes
tmp_3_5737155_G_T	1039	L>F	No	1000Genomes
tmp_3_5737159_C_T	1041	L>F	No	1000Genomes
tmp_3_5737356_A_G	1074	N>S	No	1000Genomes
tmp_3_5737422_G_A	1096	R>K	No	1000Genomes
tmp_3_5737430_G_T	1099	V>F	No	1000Genomes
tmp_3_5737485_G_T	1117	S>I	No	1000Genomes
tmp_3_5737493_G_C	1120	A>P	No	1000Genomes

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	337 - 376	IPR001680-1
repeat	WD40 repeat	393 - 437	IPR001680-2
repeat	WD40 repeat	442 - 526	IPR001680-3
repeat	WD40 repeat	529 - 572	IPR001680-4
repeat	WD40 repeat	575 - 615	IPR001680-5
repeat	WD40 repeat	817 - 858	IPR001680-6
repeat	WD40 repeat	861 - 901	IPR001680-7
repeat	WD40 repeat	904 - 952	IPR001680-8
repeat	WD40 repeat	993 - 1035	IPR001680-9
repeat	WD40 repeat	1055 - 1089	IPR001680-10
domain	LIS1 homology motif	4 - 36	IPR006594
domain	CTLH, C-terminal LisH motif	34 - 92	IPR006595
conserved_site	WD40 repeat, conserved site	470 - 484	IPR019775

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
No GO annotations for molecular function

Name	Definition
primary shoot apical meristem specification	The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0V8J1	WSB2	WD repeat and SOCS box-containing protein 2	Bos taurus (Bovine)	PR
Q6ZMY6	WDR88	WD repeat-containing protein 88	Homo sapiens (Human)	PR
Q8N157	AHI1	Jouberin	Homo sapiens (Human)	PR
Q9NYS7	WSB2	WD repeat and SOCS box-containing protein 2	Homo sapiens (Human)	PR
Q8TEB1	DCAF11	DDB1- and CUL4-associated factor 11	Homo sapiens (Human)	PR
Q5F201	Cfap52	Cilia- and flagella-associated protein 52	Mus musculus (Mouse)	PR
O54929	Wsb2	WD repeat and SOCS box-containing protein 2	Mus musculus (Mouse)	PR
Q8K3E5	Ahi1	Jouberin	Mus musculus (Mouse)	PR
A6H603	Nwd1	NACHT domain- and WD repeat-containing protein 1	Mus musculus (Mouse)	PR
Q23256	wdr-5.3	WD repeat-containing protein wdr-5.3	Caenorhabditis elegans	PR
Q94AI7	TPL	Protein TOPLESS	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WV90	TPR1	Topless-related protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR