AiPD: Autoinhibited Protein Database

Gene name	Cfap52
Protein name	Cilia- and flagella-associated protein 52
Names	WD repeat-containing protein 16
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71860
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

421-497 (Predicted disordered autoinhibitory region) PR

421-497 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8I7O	EM	450 A	P1/P2	1-620	PDB
8I7R	EM	650 A	P1/P2/P3	1-620	PDB
8IYJ	EM	350 A	e/f/g	1-620	PDB
8TO0	EM	770 A	BG/Ba/Bo	1-620	PDB
AF-Q5F201-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389166650	116	A>S	No	EVA
rs3389143083	126	L>V	No	EVA
rs241696364	146	D>E	No	EVA
rs3389139020	176	T>S	No	EVA
rs3389162497	180	G>E	No	EVA
rs3389131288	181	T>R	No	EVA
rs3389181610	194	I>F	No	EVA
rs28201388	214	A>D	No	EVA
rs240432561	214	A>T	No	EVA
rs244469639	222	L>V	No	EVA
rs3389167258	252	G>A	No	EVA
rs3411652431	257	R>W	No	EVA
rs236320890	287	V>I	No	EVA
rs3389174907	307	V>SDG*	No	EVA
rs3412457484	310	E>G	No	EVA
rs3389143075	361	T>S	No	EVA
rs3389166656	365	R>Q	No	EVA
rs3389174878	443	V>M	No	EVA
rs231412524	449	Q>E	No	EVA
rs3389162524	458	K>*	No	EVA
rs3389131222	463	S>F	No	EVA
rs3389170180	492	R>L	No	EVA
rs3389169647	493	L>H	No	EVA
rs3402251743	525	K>L*	No	EVA
rs3389169619	572	W>S	No	EVA
rs224739401	576	E>Q	No	EVA
rs3389167589	599	N>K	No	EVA

Type	Name	Position	InterPro Accession
domain	von Willebrand factor, type A	319 - 483	IPR002035

		Description
EC Number
Subcellular Localization	Cytoplasm Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme	Located in the proximal region of respiratory cilia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
9+2 motile cilium	A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
axonemal microtubule	A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

Name	Definition
No GO annotations for molecular function

Name	Definition
cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
establishment of left/right asymmetry	The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves.
flagellated sperm motility	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0V8J1	WSB2	WD repeat and SOCS box-containing protein 2	Bos taurus (Bovine)	PR
Q6ZMY6	WDR88	WD repeat-containing protein 88	Homo sapiens (Human)	PR
Q8N157	AHI1	Jouberin	Homo sapiens (Human)	PR
Q9NYS7	WSB2	WD repeat and SOCS box-containing protein 2	Homo sapiens (Human)	PR
Q8TEB1	DCAF11	DDB1- and CUL4-associated factor 11	Homo sapiens (Human)	PR
O54929	Wsb2	WD repeat and SOCS box-containing protein 2	Mus musculus (Mouse)	PR
Q8K3E5	Ahi1	Jouberin	Mus musculus (Mouse)	PR
A6H603	Nwd1	NACHT domain- and WD repeat-containing protein 1	Mus musculus (Mouse)	PR
Q23256	wdr-5.3	WD repeat-containing protein wdr-5.3	Caenorhabditis elegans	PR
Q94AI7	TPL	Protein TOPLESS	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WV90	TPR1	Topless-related protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LRZ0	TPR2	Topless-related protein 2	Arabidopsis thaliana (Mouse-ear cress)	PR