Q94AI7

PR
Gene name
TPL (WSIP1, At1g15750, F7H2.9)
Protein name
Protein TOPLESS
Names
WUS-interacting protein 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G15750
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

217-309 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q94AI7

Entry ID Method Resolution Chain Position Source
5NQS X-ray 261 A A/B 3-184 PDB
5NQV X-ray 195 A A/B/C/D 3-184 PDB
AF-Q94AI7-F1 Predicted AlphaFoldDB

28 variants for Q94AI7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01056252 53 V>I No 1000Genomes
tmp_1_5419238_C_A 237 G>V No 1000Genomes
ENSVATH04582884 269 A>T No 1000Genomes
ENSVATH11291479 291 A>S No 1000Genomes
ENSVATH04582877 309 P>S No 1000Genomes
ENSVATH11291476 379 D>N No 1000Genomes
ENSVATH11291475 384 E>D No 1000Genomes
tmp_1_5418529_C_T 386 G>D No 1000Genomes
tmp_1_5418197_A_T 445 S>T No 1000Genomes
tmp_1_5418168_T_G 454 Q>H No 1000Genomes
ENSVATH00025571 628 A>T No 1000Genomes
tmp_1_5417087_C_T 703 A>T No 1000Genomes
ENSVATH00025568 707 G>S No 1000Genomes
ENSVATH11291410 709 A>G No 1000Genomes
ENSVATH13903432 722 N>T No 1000Genomes
tmp_1_5416617_C_T 804 A>T No 1000Genomes
tmp_1_5416465_G_T 830 A>D No 1000Genomes
ENSVATH11291316 952 E>Q No 1000Genomes
ENSVATH04582854 953 K>N No 1000Genomes
ENSVATH00025565 957 K>M No 1000Genomes
ENSVATH04582852 992 L>F No 1000Genomes
ENSVATH00025561 1020 F>L No 1000Genomes
tmp_1_5415543_C_T 1023 D>N No 1000Genomes
ENSVATH04582850 1048 C>Y No 1000Genomes
ENSVATH11291293 1050 V>L No 1000Genomes
tmp_1_5415286_G_A 1066 H>Y No 1000Genomes
ENSVATH00025559 1115 A>T No 1000Genomes
ENSVATH11291266 1130 Q>R No 1000Genomes

No associated diseases with Q94AI7

13 regional properties for Q94AI7

Type Name Position InterPro Accession
repeat WD40 repeat 345 - 384 IPR001680-1
repeat WD40 repeat 406 - 445 IPR001680-2
repeat WD40 repeat 451 - 536 IPR001680-3
repeat WD40 repeat 539 - 582 IPR001680-4
repeat WD40 repeat 585 - 634 IPR001680-5
repeat WD40 repeat 825 - 862 IPR001680-6
repeat WD40 repeat 865 - 905 IPR001680-7
repeat WD40 repeat 908 - 956 IPR001680-8
repeat WD40 repeat 999 - 1040 IPR001680-9
repeat WD40 repeat 1053 - 1093 IPR001680-10
domain LIS1 homology motif 4 - 36 IPR006594
domain CTLH, C-terminal LisH motif 34 - 92 IPR006595
conserved_site WD40 repeat, conserved site 479 - 493 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.

6 GO annotations of biological process

Name Definition
jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
primary shoot apical meristem specification The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
response to auxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
xylem and phloem pattern formation The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0V8J1 WSB2 WD repeat and SOCS box-containing protein 2 Bos taurus (Bovine) PR
Q6ZMY6 WDR88 WD repeat-containing protein 88 Homo sapiens (Human) PR
Q8N157 AHI1 Jouberin Homo sapiens (Human) PR
Q9NYS7 WSB2 WD repeat and SOCS box-containing protein 2 Homo sapiens (Human) PR
Q8TEB1 DCAF11 DDB1- and CUL4-associated factor 11 Homo sapiens (Human) PR
Q5F201 Cfap52 Cilia- and flagella-associated protein 52 Mus musculus (Mouse) PR
O54929 Wsb2 WD repeat and SOCS box-containing protein 2 Mus musculus (Mouse) PR
Q8K3E5 Ahi1 Jouberin Mus musculus (Mouse) PR
A6H603 Nwd1 NACHT domain- and WD repeat-containing protein 1 Mus musculus (Mouse) PR
Q23256 wdr-5.3 WD repeat-containing protein wdr-5.3 Caenorhabditis elegans PR
Q9LRZ0 TPR2 Topless-related protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WV90 TPR1 Topless-related protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSSLSRELVF LILQFLDEEK FKETVHKLEQ ESGFFFNMKY FEDEVHNGNW DEVEKYLSGF
70 80 90 100 110 120
TKVDDNRYSM KIFFEIRKQK YLEALDKHDR PKAVDILVKD LKVFSTFNEE LFKEITQLLT
130 140 150 160 170 180
LENFRENEQL SKYGDTKSAR AIMLVELKKL IEANPLFRDK LQFPTLRNSR LRTLINQSLN
190 200 210 220 230 240
WQHQLCKNPR PNPDIKTLFV DHSCGPPNGA RAPSPVNNPL LGGIPKAGGF PPLGAHGPFQ
250 260 270 280 290 300
PTASPVPTPL AGWMSSPSSV PHPAVSAGAI ALGGPSIPAA LKHPRTPPTN ASLDYPSADS
310 320 330 340 350 360
EHVSKRTRPM GISDEVNLGV NMLPMSFSGQ AHGHSPAFKA PDDLPKTVAR TLSQGSSPMS
370 380 390 400 410 420
MDFHPIKQTL LLVGTNVGDI GLWEVGSRER LVQKTFKVWD LSKCSMPLQA ALVKEPVVSV
430 440 450 460 470 480
NRVIWSPDGS LFGVAYSRHI VQLYSYHGGE DMRQHLEIDA HVGGVNDISF STPNKQLCVI
490 500 510 520 530 540
TCGDDKTIKV WDAATGVKRH TFEGHEAPVY SVCPHYKENI QFIFSTALDG KIKAWLYDNM
550 560 570 580 590 600
GSRVDYDAPG RWCTTMAYSA DGTRLFSCGT SKDGESFIVE WNESEGAVKR TYQGFHKRSL
610 620 630 640 650 660
GVVQFDTTKN RYLAAGDDFS IKFWDMDAVQ LLTAIDGDGG LQASPRIRFN KEGSLLAVSG
670 680 690 700 710 720
NENVIKIMAN SDGLRLLHTF ENISSESSKP AINSIAAAAA AAATSAGHAD RSANVVSIQG
730 740 750 760 770 780
MNGDSRNMVD VKPVITEESN DKSKIWKLTE VSEPSQCRSL RLPENLRVAK ISRLIFTNSG
790 800 810 820 830 840
NAILALASNA IHLLWKWQRN ERNATGKATA SLPPQQWQPA SGILMTNDVA ETNPEEAVPC
850 860 870 880 890 900
FALSKNDSYV MSASGGKISL FNMMTFKTMA TFMPPPPAAT FLAFHPQDNN IIAIGMDDST
910 920 930 940 950 960
IQIYNVRVDE VKSKLKGHSK RITGLAFSNV LNVLVSSGAD AQLCVWNTDG WEKQRSKVLP
970 980 990 1000 1010 1020
LPQGRPNSAP SDTRVQFHQD QAHFLVVHET QLAIYETTKL ECMKQWAVRE SLAPITHATF
1030 1040 1050 1060 1070 1080
SCDSQLVYAS FMDATVCVFS SANLRLRCRV NPSAYLPASL SNSNVHPLVI AAHPQEPNMF
1090 1100 1110 1120 1130
AVGLSDGGVH IFEPLESEGK WGVAPPAENG SASGAPTAPS VGASASDQPQ R