Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6H603
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6H603-F1 | Predicted | AlphaFoldDB |
90 variants for A6H603
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388991940 | 3 | T>K | No | EVA | |
| rs3388973620 | 11 | T>I | No | EVA | |
| rs211797561 | 26 | A>V | No | EVA | |
| rs3388961660 | 29 | V>A | No | EVA | |
| rs3388961688 | 66 | F>L | No | EVA | |
| rs3413112120 | 89 | E>G | No | EVA | |
| rs108371156 | 178 | S>N | No | EVA | |
| rs3388944202 | 198 | K>R | No | EVA | |
| rs3388996080 | 211 | R>W | No | EVA | |
| rs33895624 | 213 | V>A | No | EVA | |
| rs3388992443 | 224 | L>P | No | EVA | |
| rs3412866979 | 250 | D>N | No | EVA | |
| rs3388992287 | 253 | N>Y | No | EVA | |
| rs3388988994 | 256 | N>K | No | EVA | |
| rs33896221 | 326 | Q>R | No | EVA | |
| rs3388992278 | 372 | R>M | No | EVA | |
| rs3388991829 | 374 | L>V | No | EVA | |
| rs247552589 | 410 | A>V | No | EVA | |
| rs3388985680 | 419 | H>Q | No | EVA | |
| rs261096798 | 427 | Q>P | No | EVA | |
| rs261096798 | 427 | Q>R | No | EVA | |
| rs3388996018 | 459 | C>Y | No | EVA | |
| rs3388996635 | 478 | N>S | No | EVA | |
| rs3388968062 | 480 | Q>* | No | EVA | |
| rs3399285359 | 483 | L>PVGAGVLEGLLQVM* | No | EVA | |
| rs3398815647 | 501 | Q>* | No | EVA | |
| rs250936266 | 505 | Q>H | No | EVA | |
| rs3388988791 | 514 | M>T | No | EVA | |
| rs3388961648 | 518 | G>A | No | EVA | |
| rs3388988857 | 557 | T>I | No | EVA | |
| rs3388992213 | 560 | E>D | No | EVA | |
| rs3388944148 | 573 | T>I | No | EVA | |
| rs3399456684 | 575 | G>E | No | EVA | |
| rs227148998 | 611 | A>S | No | EVA | |
| rs3398981310 | 624 | L>Q | No | EVA | |
| rs3399248470 | 625 | R>L | No | EVA | |
| rs3388996623 | 638 | L>P | No | EVA | |
| rs3399174605 | 655 | I>F | No | EVA | |
| rs3388961713 | 678 | H>Y | No | EVA | |
| rs238932709 | 696 | L>R | No | EVA | |
| rs3388996582 | 719 | F>I | No | EVA | |
| rs3388992218 | 733 | P>L | No | EVA | |
| rs3388984819 | 735 | H>R | No | EVA | |
| rs3388992238 | 743 | E>* | No | EVA | |
| rs3399258786 | 752 | N>D | No | EVA | |
| rs3388979568 | 764 | G>D | No | EVA | |
| rs3388979487 | 776 | A>V | No | EVA | |
| rs49149947 | 780 | N>D | No | EVA | |
| rs3388988980 | 786 | L>Q | No | EVA | |
| rs3388973665 | 790 | A>V | No | EVA | |
| rs3388992284 | 793 | L>Q | No | EVA | |
| rs50165233 | 807 | V>I | No | EVA | |
| rs3388944158 | 815 | R>* | No | EVA | |
| rs3388996025 | 843 | Y>* | No | EVA | |
| rs3388988863 | 846 | L>M | No | EVA | |
| rs3388984781 | 873 | A>T | No | EVA | |
| rs3388973661 | 898 | E>G | No | EVA | |
| rs3388992277 | 990 | K>* | No | EVA | |
| rs3388984726 | 992 | V>A | No | EVA | |
| rs3388968055 | 1003 | W>C | No | EVA | |
| rs46272481 | 1031 | M>T | No | EVA | |
| rs3388992268 | 1042 | S>G | No | EVA | |
| rs47839072 | 1096 | D>E | No | EVA | |
| rs3388992280 | 1101 | A>P | No | EVA | |
| rs218917474 | 1135 | V>A | No | EVA | |
| rs3388991953 | 1160 | Q>K | No | EVA | |
| rs3388979551 | 1167 | L>I | No | EVA | |
| rs213838935 | 1178 | V>I | No | EVA | |
| rs3399245080 | 1180 | G>D | No | EVA | |
| rs3399285357 | 1240 | I>N | No | EVA | |
| rs3398981350 | 1241 | W>C | No | EVA | |
| rs3399248449 | 1246 | G>C | No | EVA | |
| rs3388992411 | 1268 | K>M | No | EVA | |
| rs3388996053 | 1289 | D>H | No | EVA | |
| rs3388988801 | 1338 | G>C | No | EVA | |
| rs3388985612 | 1372 | F>I | No | EVA | |
| rs3388968086 | 1382 | F>L | No | EVA | |
| rs3399245186 | 1398 | H>P | No | EVA | |
| rs3388991933 | 1410 | A>E | No | EVA | |
| rs237177178 | 1428 | Y>C | No | EVA | |
| rs253523251 | 1433 | C>G | No | EVA | |
| rs3398797994 | 1434 | R>K | No | EVA | |
| rs3388992456 | 1439 | A>D | No | EVA | |
| rs3388984814 | 1481 | I>T | No | EVA | |
| rs49268482 | 1481 | I>V | No | EVA | |
| rs50005393 | 1500 | R>C | No | EVA | |
| rs3388988877 | 1507 | R>I | No | EVA | |
| rs3388961659 | 1521 | V>M | No | EVA | |
| rs52063264 | 1535 | A>T | No | EVA | |
| rs3388988795 | 1536 | E>V | No | EVA |
No associated diseases with A6H603
11 regional properties for A6H603
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 857 - 947 | IPR001680-1 |
| repeat | WD40 repeat | 988 - 1028 | IPR001680-2 |
| repeat | WD40 repeat | 1118 - 1198 | IPR001680-3 |
| repeat | WD40 repeat | 1245 - 1283 | IPR001680-4 |
| repeat | WD40 repeat | 1286 - 1326 | IPR001680-5 |
| repeat | WD40 repeat | 1340 - 1375 | IPR001680-6 |
| repeat | WD40 repeat | 1377 - 1418 | IPR001680-7 |
| repeat | WD40 repeat | 1421 - 1461 | IPR001680-8 |
| domain | NACHT nucleoside triphosphatase | 338 - 505 | IPR007111 |
| conserved_site | WD40 repeat, conserved site | 1403 - 1417 | IPR019775 |
| domain | Anaphase-promoting complex subunit 4-like, WD40 domain | 869 - 916 | IPR024977 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of NF-kappaB transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8J1 | WSB2 | WD repeat and SOCS box-containing protein 2 | Bos taurus (Bovine) | PR |
| Q6ZMY6 | WDR88 | WD repeat-containing protein 88 | Homo sapiens (Human) | PR |
| Q8N157 | AHI1 | Jouberin | Homo sapiens (Human) | PR |
| Q9NYS7 | WSB2 | WD repeat and SOCS box-containing protein 2 | Homo sapiens (Human) | PR |
| Q8TEB1 | DCAF11 | DDB1- and CUL4-associated factor 11 | Homo sapiens (Human) | PR |
| Q149M9 | NWD1 | NACHT domain- and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q5F201 | Cfap52 | Cilia- and flagella-associated protein 52 | Mus musculus (Mouse) | PR |
| O54929 | Wsb2 | WD repeat and SOCS box-containing protein 2 | Mus musculus (Mouse) | PR |
| Q8K3E5 | Ahi1 | Jouberin | Mus musculus (Mouse) | PR |
| Q23256 | wdr-5.3 | WD repeat-containing protein wdr-5.3 | Caenorhabditis elegans | PR |
| Q94AI7 | TPL | Protein TOPLESS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WV90 | TPR1 | Topless-related protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ0 | TPR2 | Topless-related protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTEREALQC | TAYPEVQSFC | QRHGLAFEVV | DLRWGIPNTQ | ATDYLTTELC | LEELERCQKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SIGPAFVALL | GDQYGPCPVP | RRIEEKEWEA | LRAQLTSRPR | DLELVTRHFQ | RDDNTIPPTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLQPSGSLVV | PGPEEATLTS | VLRGGAQEAW | RLGLISQEQW | MCYHRSVIEW | EIELGLLSSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGDQGATVFL | RDVQDLNKHI | LDDCSLKMVD | RLVDGCLDTN | AQSLLSGLKG | RILDAQPGAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSHHLSWSRD | LVNPKNKAHA | RYLKQLSEQF | VARTNHQVLE | QLRELELARQ | ELGWLYQEIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HHLWQSTEST | KVFCGHQELL | AQLRQQLRQD | ESRTHTPLVL | FGPPGIGKTS | LMCKLAQQVP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELLGHKTVVV | LRLLGTSKLS | LDARSLLRSL | SFQVCLAYGL | PLPPAQVLEA | HSRVGHFFHT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLHTVSQRNF | ESLVLLLDSV | DDLDSICHSP | RVSWLPLKCP | PRVHLILSTC | SGQQVLHNLQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QTLKDPSTYW | EVKALSGSQG | QEFIQLLLAA | EKRMLSPGQR | DVLWASLPEC | GHPGRLRLAF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EEARKWASFT | VPVPLATTAE | EATHQLCIRL | EETHGALLVA | HVLGYIVSSR | YGLSEAELKD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLSLDDEVLQ | AVYRDWTPPS | KELLRFPPLL | WVRLRRDLGH | CLVRRPVDGC | MLLAIAHRQL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SQVIQVRYLS | GPERAKRHGV | LAEFFSGAWS | QGIKKLITLP | LVGKPLNLDR | KVAPQPLWFS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| STVANLRKLT | ELPFHLLHAG | RLEELKQEVL | GNMSWISCRG | ISGGIEVLLD | DFDMCAPHMN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SPEVDLVREA | IQLCGPAVEL | RGLEKSVLYT | ELLARLLFFA | ASHPAMIGQL | CQQAQSWFRA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| CPYPMLVPLA | GFLQPPGGPL | RATLTGCHKG | ITAIAWSLEE | KLLVVGTQDG | AMVVWDVEEQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QVVHVLMGHT | AEVKCVRVFA | QGTLAISASK | DHTLRLWSLL | SGQEKVTILD | GGSQNPTEPQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SWDLHVDERN | NVVYSTSGAR | INMWNLETSK | LVFCITGDVS | DPWVCVALLA | AQGLLLALSK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GGQVSLWSSA | MGKLQEKHQL | SSIKEETPTC | AVSIQSRARL | VAGFSSGSIA | LVSAGEDRLL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EKLPEAVGFL | VVSEDDSLLV | AGFGRFVRIF | LADSQGFHRF | MASDLEHEDM | VETAVLGPEN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NLIITGSRDA | LIQVWSLSEQ | GTLLNVLEGV | GAPVSLLVRG | GTLVVSASRK | SSSFKVWDLK |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| STKKLQSPTP | FLDRTGLAAV | SHHGSFVYFP | KVGDKNKVTI | WDLAEGEEQD | CLDTSNEVRC |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LEVAEQAKLL | FTGLVSGIVL | VFPLNSRQDV | LCIPPPEARK | AVNCMSLSKS | ENRLAIAYDN |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| IVLVLDISPG | DPCPAIEGPT | YTFYTQLPET | IVSVAVLADY | RVVYGMSDGS | LFLYDCACSK |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| VFPLEAHGSR | VSCVEVSHSE | QLAVSGAEDA | LLCLWDLQAC | RGMFEMSYEN | SCCRGVRCAC |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FSRDDKHVFA | GMEDRSVTAW | STVDGTLLAV | QFVHAVINRI | IPTSNGFMAP | TSHGYLIRER |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| FQCPSVRASQ | QDPLKNFKKA | VWLVKTRQRE | ELAAAEASQD | AEPVAVEGKE | SKSNKRSQVC |
| LIL |