O54929

PR
Gene name
Wsb2 (Swip2)
Protein name
WD repeat and SOCS box-containing protein 2
Names
WSB-2, SOCS box-containing WD protein SWiP-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:59043
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O54929

Entry ID Method Resolution Chain Position Source
AF-O54929-F1 Predicted AlphaFoldDB

22 variants for O54929

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388770936 55 W>* No EVA
rs3388776031 75 N>K No EVA
rs3388781752 76 D>N No EVA
rs3388784111 81 G>D No EVA
rs3388790818 86 K>N No EVA
rs3388784924 94 V>M No EVA
rs3388786301 101 P>S No EVA
rs3388767251 121 V>D No EVA
rs3388784730 139 E>V No EVA
rs3388756695 147 L>M No EVA
rs3388785296 211 M>I No EVA
rs3388756765 266 W>* No EVA
rs3395400180 269 Y>C No EVA
rs3388784718 288 D>V No EVA
rs3388784768 296 L>Q No EVA
rs3388771003 332 P>Q No EVA
rs3388781780 334 T>S No EVA
rs3388773396 358 Q>H No EVA
rs3396225944 368 S>* No EVA
rs3388767303 390 P>S No EVA
rs3388785331 396 K>R No EVA
rs3388786293 397 E>V No EVA

No associated diseases with O54929

No regional properties for O54929

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O54929

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0V8J1 WSB2 WD repeat and SOCS box-containing protein 2 Bos taurus (Bovine) PR
Q6ZMY6 WDR88 WD repeat-containing protein 88 Homo sapiens (Human) PR
Q8N157 AHI1 Jouberin Homo sapiens (Human) PR
Q8TEB1 DCAF11 DDB1- and CUL4-associated factor 11 Homo sapiens (Human) PR
Q9NYS7 WSB2 WD repeat and SOCS box-containing protein 2 Homo sapiens (Human) PR
Q5F201 Cfap52 Cilia- and flagella-associated protein 52 Mus musculus (Mouse) PR
Q8K3E5 Ahi1 Jouberin Mus musculus (Mouse) PR
A6H603 Nwd1 NACHT domain- and WD repeat-containing protein 1 Mus musculus (Mouse) PR
Q23256 wdr-5.3 WD repeat-containing protein wdr-5.3 Caenorhabditis elegans PR
Q94AI7 TPL Protein TOPLESS Arabidopsis thaliana (Mouse-ear cress) PR
Q0WV90 TPR1 Topless-related protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ0 TPR2 Topless-related protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCVV KLVPWPLEEQ
70 80 90 100 110 120
FIPKGFEAKS RSSKNDPKGR GSLKEKTLDC GQIVWGLAFS PWPSPPSRKL WARHHPQAPD
130 140 150 160 170 180
VSCLILATGL NDGQIKIWEV QTGLLLLNLS GHQDVVRDLS FTPSGSLILV SASRDKTLRI
190 200 210 220 230 240
WDLNKHGKQI QVLSGHLQWV YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS
250 260 270 280 290 300
SVVSCDFSPD SALLVTASYD TSVIMWDPYT GERLRSLHHT QLEPTMDDSD VHMSSLRSVC
310 320 330 340 350 360
FSPEGLYLAT VADDRLLRIW ALELKAPVAF APMTNGLCCT FFPHGGIIAT GTRDGHVQFW
370 380 390 400
TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT YRTF