Q0WV90
PR
Gene name |
TPR1 (MOS10, At1g80490, F7H12, T21F11.18) |
Protein name |
Topless-related protein 1 |
Names |
Protein MODIFIER OF SNC1 10 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G80490 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0WV90
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0WV90-F1 | Predicted | AlphaFoldDB |
47 variants for Q0WV90
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_30266233_C_T | 48 | G>S | No | 1000Genomes | |
| ENSVATH14496654 | 205 | R>H | No | 1000Genomes | |
| tmp_1_30265356_G_A | 243 | P>L | No | 1000Genomes | |
| ENSVATH05179644 | 261 | P>S | No | 1000Genomes | |
| ENSVATH13845048 | 263 | P>S | No | 1000Genomes | |
| tmp_1_30265264_C_T | 274 | A>T | No | 1000Genomes | |
| tmp_1_30265261_G_A | 275 | P>S | No | 1000Genomes | |
| ENSVATH00800292 | 299 | D>E | No | 1000Genomes | |
| tmp_1_30265047_A_C | 300 | S>A | No | 1000Genomes | |
| ENSVATH05179641 | 317 | S>N | No | 1000Genomes | |
| ENSVATH13845041 | 385 | V>I | No | 1000Genomes | |
| ENSVATH13845040 | 388 | R>Q | No | 1000Genomes | |
| tmp_1_30264554_G_C | 395 | T>S | No | 1000Genomes | |
| tmp_1_30264524_G_A | 405 | S>L | No | 1000Genomes | |
| tmp_1_30264385_C_T | 423 | V>M | No | 1000Genomes | |
| tmp_1_30264102_T_A | 468 | I>F | No | 1000Genomes | |
| tmp_1_30264065_G_T | 480 | T>N | No | 1000Genomes | |
| tmp_1_30263924_T_C | 495 | T>A | No | 1000Genomes | |
| tmp_1_30262909_A_T | 707 | I>N | No | 1000Genomes | |
| ENSVATH05179623 | 731 | K>N | No | 1000Genomes | |
| tmp_1_30262720_C_T | 741 | G>D | No | 1000Genomes | |
| ENSVATH14496649 | 774 | A>T | No | 1000Genomes | |
| ENSVATH05179622 | 791 | R>C | No | 1000Genomes | |
| tmp_1_30262502_C_T | 791 | R>H | No | 1000Genomes | |
| tmp_1_30262097_G_A | 869 | T>M | No | 1000Genomes | |
| tmp_1_30261947_A_T | 919 | V>E | No | 1000Genomes | |
| tmp_1_30261948_C_T | 919 | V>I | No | 1000Genomes | |
| tmp_1_30261939_C_A | 922 | V>F | No | 1000Genomes | |
| ENSVATH07699565 | 934 | V>I | No | 1000Genomes | |
| tmp_1_30261782_C_G | 947 | V>L | No | 1000Genomes | |
| tmp_1_30261763_C_T | 953 | G>E | No | 1000Genomes | |
| tmp_1_30261751_G_A | 957 | S>F | No | 1000Genomes | |
| tmp_1_30261733_C_T | 963 | R>H | No | 1000Genomes | |
| ENSVATH00800289 | 990 | E>D | No | 1000Genomes | |
| tmp_1_30261643_T_G | 993 | K>T | No | 1000Genomes | |
| tmp_1_30261548_G_C | 996 | P>R | No | 1000Genomes | |
| ENSVATH14496647 | 1007 | A>G | No | 1000Genomes | |
| ENSVATH13845026 | 1031 | A>E | No | 1000Genomes | |
| tmp_1_30261291_G_A | 1056 | P>S | No | 1000Genomes | |
| ENSVATH13845024 | 1067 | N>I | No | 1000Genomes | |
| ENSVATH05179614 | 1071 | V>A | No | 1000Genomes | |
| tmp_1_30261234_C_T | 1075 | D>N | No | 1000Genomes | |
| tmp_1_30261214_G_A,T | 1081 | F>L | No | 1000Genomes | |
| ENSVATH13845023 | 1087 | E>A | No | 1000Genomes | |
| ENSVATH13845022 | 1105 | T>P | No | 1000Genomes | |
| ENSVATH13845021 | 1107 | T>K | No | 1000Genomes | |
| ENSVATH01562719 | 1116 | D>V | No | 1000Genomes |
No associated diseases with Q0WV90
13 regional properties for Q0WV90
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 345 - 384 | IPR001680-1 |
| repeat | WD40 repeat | 406 - 445 | IPR001680-2 |
| repeat | WD40 repeat | 451 - 536 | IPR001680-3 |
| repeat | WD40 repeat | 539 - 582 | IPR001680-4 |
| repeat | WD40 repeat | 585 - 669 | IPR001680-5 |
| repeat | WD40 repeat | 814 - 851 | IPR001680-6 |
| repeat | WD40 repeat | 854 - 894 | IPR001680-7 |
| repeat | WD40 repeat | 897 - 945 | IPR001680-8 |
| repeat | WD40 repeat | 988 - 1029 | IPR001680-9 |
| repeat | WD40 repeat | 1042 - 1082 | IPR001680-10 |
| domain | LIS1 homology motif | 4 - 36 | IPR006594 |
| domain | CTLH, C-terminal LisH motif | 34 - 92 | IPR006595 |
| conserved_site | WD40 repeat, conserved site | 479 - 493 | IPR019775 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| primary shoot apical meristem specification | The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8J1 | WSB2 | WD repeat and SOCS box-containing protein 2 | Bos taurus (Bovine) | PR |
| Q6ZMY6 | WDR88 | WD repeat-containing protein 88 | Homo sapiens (Human) | PR |
| Q8N157 | AHI1 | Jouberin | Homo sapiens (Human) | PR |
| Q9NYS7 | WSB2 | WD repeat and SOCS box-containing protein 2 | Homo sapiens (Human) | PR |
| Q8TEB1 | DCAF11 | DDB1- and CUL4-associated factor 11 | Homo sapiens (Human) | PR |
| Q5F201 | Cfap52 | Cilia- and flagella-associated protein 52 | Mus musculus (Mouse) | PR |
| O54929 | Wsb2 | WD repeat and SOCS box-containing protein 2 | Mus musculus (Mouse) | PR |
| Q8K3E5 | Ahi1 | Jouberin | Mus musculus (Mouse) | PR |
| A6H603 | Nwd1 | NACHT domain- and WD repeat-containing protein 1 | Mus musculus (Mouse) | PR |
| Q23256 | wdr-5.3 | WD repeat-containing protein wdr-5.3 | Caenorhabditis elegans | PR |
| Q94AI7 | TPL | Protein TOPLESS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ0 | TPR2 | Topless-related protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSLSRELVF | LILQFLDEEK | FKETVHKLEQ | ESGFFFNMKY | FEDEVHNGNW | DEVEKYLSGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKVDDNRYSM | KIFFEIRKQK | YLEALDRHDR | PKAVDILVKD | LKVFSTFNEE | LFKEITQLLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LENFRENEQL | SKYGDTKSAR | AIMLVELKKL | IEANPLFRDK | LQFPTLRTSR | LRTLINQSLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WQHQLCKNPR | PNPDIKTLFV | DHSCRLPNDA | RAPSPVNNPL | LGSLPKAEGF | PPLGAHGPFQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PTPSPVPTPL | AGWMSSPSSV | PHPAVSGGPI | ALGAPSIQAA | LKHPRTPPSN | SAVDYPSGDS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DHVSKRTRPM | GISDEVSLGV | NMLPMTFPGQ | AHGHNQTFKA | PDDLPKTVAR | TLSQGSSPMS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MDFHPIKQTL | LLVGTNVGDI | GLWEVGSRER | LVQKTFKVWD | LSKCSMPLQA | ALVKEPVVSV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NRVIWSPDGS | LFGVAYSRHI | VQLYSYHGGE | DMRQHLEIDA | HVGGVNDIAF | STPNKQLCVT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TCGDDKTIKV | WDAATGVKRY | TFEGHEAPVY | SICPHYKENI | QFIFSTALDG | KIKAWLYDNM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GSRVDYEAPG | RWCTTMAYSA | DGTRLFSCGT | SKDGESFIVE | WNESEGAVKR | TYQGFHKRSL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GVVQFDTTKN | RYLAAGDDFS | IKFWDMDTIQ | LLTAIDADGG | LQASPRIRFN | KEGSLLAVSA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NDNMIKVMAN | SDGLRLLHTV | ENLSSESSKP | AINSIPMVER | PASVVSIPGM | NGDSRNMVDV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KPVITEESND | KSKVWKLTEV | GEPSQCRSLR | LPENMRVTKI | SRLIFTNSGN | AILALASNAI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HLLWKWQRND | RNATGKATAS | LPPQQWQPAS | GILMTNDVAE | TNPEEAVPCF | ALSKNDSYVM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SASGGKISLF | NMMTFKTMAT | FMPPPPAATF | LAFHPQDNNI | IAIGMDDSTI | QIYNVRVDEV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KSKLKGHSKR | ITGLAFSNVL | NVLVSSGADA | QLCVWNTDGW | EKQKSKVLQI | PQGRSTSSLS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DTRVQFHQDQ | VHFLVVHETQ | LAIYETTKLE | CMKQWPVRES | AAPITHATFS | CDSQLIYTSF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| MDATICVFSS | ANLRLRCRVN | PSAYLPASLS | NSNVHPLVIA | AHPQESNMFA | VGLSDGGVHI |
| 1090 | 1100 | 1110 | |||
| FEPLESEGKW | GVAPPPENGS | ASAVTATPSV | GASASDQPQR |