Q9JJV9
PR
Gene name |
Scn5a |
Protein name |
Sodium channel protein type 5 subunit alpha |
Names |
Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5, mH1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20271 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JJV9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JJV9-F1 | Predicted | AlphaFoldDB |
91 variants for Q9JJV9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389070286 | 17 | T>N | No | EVA | |
| rs252874141 | 39 | S>L | No | EVA | |
| rs3389087304 | 40 | Q>H | No | EVA | |
| rs226263944 | 43 | R>H | No | EVA | |
| rs3389082425 | 48 | E>D | No | EVA | |
| rs3389083633 | 52 | P>S | No | EVA | |
| rs3389070296 | 71 | P>L | No | EVA | |
| rs3389082443 | 74 | E>D | No | EVA | |
| rs3389077605 | 75 | L>F | No | EVA | |
| rs3399647459 | 86 | F>V | No | EVA | |
| rs3389026705 | 106 | S>N | No | EVA | |
| rs3389057505 | 120 | V>E | No | EVA | |
| rs3389093119 | 139 | C>* | No | EVA | |
| rs3400793959 | 166 | A>D | No | EVA | |
| rs3389083693 | 175 | K>E | No | EVA | |
| rs3389080972 | 199 | S>N | No | EVA | |
| rs3389080963 | 200 | V>E | No | EVA | |
| rs3389082545 | 211 | D>N | No | EVA | |
| rs3389077550 | 213 | G>D | No | EVA | |
| rs3389062407 | 251 | A>V | No | EVA | |
| rs3389062405 | 299 | I>M | No | EVA | |
| rs3389093124 | 300 | V>F | No | EVA | |
| rs3389077609 | 301 | W>R | No | EVA | |
| rs3389026755 | 303 | S>F | No | EVA | |
| rs3389082586 | 341 | C>Y | No | EVA | |
| rs3389074712 | 345 | G>S | No | EVA | |
| rs3389083651 | 475 | R>S | No | EVA | |
| rs3389082594 | 490 | G>R | No | EVA | |
| rs3389050471 | 501 | D>E | No | EVA | |
| rs3389083643 | 562 | L>P | No | EVA | |
| rs3389050487 | 566 | P>L | No | EVA | |
| rs3389026743 | 609 | A>T | No | EVA | |
| rs3389086015 | 652 | G>D | No | EVA | |
| rs3389077582 | 664 | S>R | No | EVA | |
| rs3389050451 | 671 | S>R | No | EVA | |
| rs3389093167 | 823 | P>H | No | EVA | |
| rs3389077621 | 950 | T>I | No | EVA | |
| rs3389082393 | 952 | P>R | No | EVA | |
| rs3389062370 | 965 | L>V | No | EVA | |
| rs3389050535 | 968 | I>T | No | EVA | |
| rs3389082446 | 979 | T>I | No | EVA | |
| rs3400884179 | 984 | C>R | No | EVA | |
| rs3389050441 | 992 | K>* | No | EVA | |
| rs3389083652 | 993 | K>N | No | EVA | |
| rs3389082379 | 1001 | S>T | No | EVA | |
| rs30071926 | 1008 | A>T | No | EVA | |
| rs3389070277 | 1009 | A>G | No | EVA | |
| rs30428633 | 1009 | A>T | No | EVA | |
| rs3389057506 | 1009 | A>V | No | EVA | |
| rs3402644545 | 1011 | R>G | No | EVA | |
| rs3389077620 | 1018 | V>M | No | EVA | |
| rs3389080912 | 1037 | G>VSDG* | No | EVA | |
| rs3389087314 | 1039 | G>V | No | EVA | |
| rs3389082374 | 1040 | T>S | No | EVA | |
| rs3389057490 | 1061 | Q>H | No | EVA | |
| rs3389057424 | 1062 | E>* | No | EVA | |
| rs3389082433 | 1073 | E>G | No | EVA | |
| rs248039010 | 1133 | T>S | No | EVA | |
| rs46738906 | 1191 | K>M | No | EVA | |
| rs3389091743 | 1231 | L>M | No | EVA | |
| rs3389062410 | 1292 | T>N | No | EVA | |
| rs3389062403 | 1305 | R>T | No | EVA | |
| rs3389087297 | 1314 | R>K | No | EVA | |
| rs3389090783 | 1316 | L>V | No | EVA | |
| rs3389082623 | 1319 | F>I | No | EVA | |
| rs3389082555 | 1332 | A>P | No | EVA | |
| rs3389087352 | 1350 | F>S | No | EVA | |
| rs1134658765 | 1391 | V>M | No | EVA | |
| rs3389057437 | 1398 | T>I | No | EVA | |
| rs3389087348 | 1409 | A>T | No | EVA | |
| rs3389082394 | 1453 | V>A | No | EVA | |
| rs3389026770 | 1454 | V>F | No | EVA | |
| rs3389091690 | 1464 | L>P | No | EVA | |
| rs3389091658 | 1477 | Q>R | No | EVA | |
| rs3400174286 | 1534 | V>A | No | EVA | |
| rs3389081001 | 1554 | Q>H | No | EVA | |
| rs3389074768 | 1561 | I>N | No | EVA | |
| rs3389057460 | 1564 | K>N | No | EVA | |
| rs3389085961 | 1592 | S>I | No | EVA | |
| rs3389057472 | 1642 | A>D | No | EVA | |
| rs3389057454 | 1647 | T>M | No | EVA | |
| rs3389074779 | 1654 | M>L | No | EVA | |
| rs3389085977 | 1676 | F>I | No | EVA | |
| rs3389062428 | 1730 | C>F | No | EVA | |
| rs3389080957 | 1756 | T>I | No | EVA | |
| rs3389062393 | 1774 | L>Q | No | EVA | |
| rs3400536625 | 1830 | A>G | No | EVA | |
| rs3389062397 | 1939 | L>I | No | EVA | |
| rs3389062429 | 1957 | E>V | No | EVA | |
| rs221725406 | 1963 | S>G | No | EVA | |
| rs3389082629 | 2016 | E>* | No | EVA |
No associated diseases with Q9JJV9
7 regional properties for Q9JJV9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ion transport domain | 130 - 422 | IPR005821-1 |
| domain | Ion transport domain | 718 - 945 | IPR005821-2 |
| domain | Ion transport domain | 1206 - 1481 | IPR005821-3 |
| domain | Ion transport domain | 1530 - 1784 | IPR005821-4 |
| domain | Sodium ion transport-associated domain | 955 - 1202 | IPR010526 |
| domain | Voltage-gated Na+ ion channel, cytoplasmic domain | 508 - 667 | IPR024583 |
| domain | Voltage-gated sodium channel alpha subunit, inactivation gate | 1473 - 1525 | IPR044564 |
Functions
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| sodium channel complex | An ion channel complex through which sodium ions pass. |
| T-tubule | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. |
| voltage-gated sodium channel complex | A sodium channel in a cell membrane whose opening is governed by the membrane potential. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
17 GO annotations of molecular function
| Name | Definition |
|---|---|
| ankyrin binding | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| fibroblast growth factor binding | Binding to a fibroblast growth factor. |
| nitric-oxide synthase binding | Binding to nitric-oxide synthase. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| scaffold protein binding | Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in AV node cell action potential | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in bundle of His cell action potential | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in Purkinje myocyte action potential | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity involved in SA node cell action potential | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
36 GO annotations of biological process
| Name | Definition |
|---|---|
| atrial cardiac muscle cell action potential | An action potential that occurs in an atrial cardiac muscle cell. |
| AV node cell action potential | An action potential that occurs in an atrioventricular node cardiac muscle cell. |
| AV node cell to bundle of His cell communication | The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. |
| bundle of His cell action potential | An action potential that occurs in a bundle of His cell. |
| cardiac muscle cell action potential involved in contraction | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. |
| cardiac muscle contraction | Muscle contraction of cardiac muscle tissue. |
| cardiac ventricle development | The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. |
| cellular response to calcium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| membrane depolarization | The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during atrial cardiac muscle cell action potential | The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during AV node cell action potential | The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during bundle of His cell action potential | The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during cardiac muscle cell action potential | The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during Purkinje myocyte cell action potential | The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| membrane depolarization during SA node cell action potential | The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| neuronal action potential | An action potential that occurs in a neuron. |
| positive regulation of action potential | Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
| positive regulation of heart rate | Any process that activates or increases the frequency or rate of heart contraction. |
| positive regulation of sodium ion transport | Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of atrial cardiac muscle cell membrane depolarization | Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. |
| regulation of atrial cardiac muscle cell membrane repolarization | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. |
| regulation of cardiac muscle cell contraction | Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. |
| regulation of heart rate | Any process that modulates the frequency or rate of heart contraction. |
| regulation of heart rate by cardiac conduction | A cardiac conduction process that modulates the frequency or rate of heart contraction. |
| regulation of sodium ion transmembrane transport | Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. |
| regulation of ventricular cardiac muscle cell membrane depolarization | Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte. |
| regulation of ventricular cardiac muscle cell membrane repolarization | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. |
| response to denervation involved in regulation of muscle adaptation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. |
| response to organic cyclic compound | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| SA node cell action potential | An action potential that occurs in a sinoatrial node cardiac muscle cell. |
| sodium ion import across plasma membrane | The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ventricular cardiac muscle cell action potential | An action potential that occurs in a ventricular cardiac muscle cell. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANFLLPRGT | SSFRRFTRES | LAAIEKRMAE | KQARGSATSQ | ESREGLPEEE | APRPQLDLQA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKKLPDLYGN | PPRELIGEPL | EDLDPFYSTQ | KTFIVLNKGK | TIFRFSATNA | LYVLSPFHPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRAAVKILVH | SLFSMLIMCT | ILTNCVFMAQ | HDPPPWTKYV | EYTFTAIYTF | ESLVKILARG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FCLHAFTFLR | DPWNWLDFSV | IVMAYTTEFV | DLGNVSALRT | FRVLRALKTI | SVISGLKTIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GALIQSVKKL | ADVMVLTVFC | LSVFALIGLQ | LFMGNLRHKC | VRNFTELNGT | NGSVEADGIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WNSLDVYLND | PANYLLKNGT | TDVLLCGNSS | DAGTCPEGYR | CLKAGENPDH | GYTSFDSFAW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFLALFRLMT | QDCWERLYQQ | TLRSAGKIYM | IFFMLVIFLG | SFYLVNLILA | VVAMAYEEQN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QATIAETEEK | EKRFQEAMEM | LKKEHEALTI | RGVDTVSRSS | LEMSPLAPVT | NHERRSKRRK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLSSGTEDGG | DDRLPKSDSE | DGPRALNQLS | LTHGLSRTSM | RPRSSRGSIF | TFRRRDQGSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ADFADDENST | AGESESHRTS | LLVPWPLRRP | STQGQPGFGT | SAPGHVLNGK | RNSTVDCNGV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VSLLGAGDAE | ATSPGSHLLR | PIVLDRPPDT | TTPSEEPGGP | QMLTPQAPCA | DGFEEPGARQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RALSAVSVLT | SALEELEESH | RKCPPCWNRF | AQHYLIWECC | PLWMSIKQKV | KFVVMDPFAD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LTITMCIVLN | TLFMALEHYN | MTAEFEEMLQ | VGNLVFTGIF | TAEMTFKIIA | LDPYYYFQQG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| WNIFDSIIVI | LSLMELGLSR | MGNLSVLRSF | RLLRVFKLAK | SWPTLNTLIK | IIGNSVGALG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NLTLVLAIIV | FIFAVVGMQL | FGKNYSELRH | RISDSGLLPR | WHMMDFFHAF | LIIFRILCGE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WIETMWDCME | VSGQSLCLLV | FLLVMVIGNL | VVLNLFLALL | LSSFSADNLT | APDEDGEMNN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LQLALARIQR | GLRFVKRTTW | DFCCGLLRRR | PKKPAALATH | SQLPSCIAAP | RSPPPPEVEK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| APPARKETRF | EEDKRPGQGT | PGDTEPVCVP | IAVAESDTDD | QEEDEENSLG | TEEEESSKQE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SQVVSGGHEP | PQEPRAWSQV | SETTSSEAEA | STSQADWQQE | REAEPRAPGC | GETPEDSYSE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GSTADMTNTA | DLLEQIPDLG | EDVKDPEDCF | TEGCVRRCPC | CMVDTTQAPG | KVWWRLRKTC |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| YRIVEHSWFE | TFIIFMILLS | SGALAFEDIY | LEERKTIKVL | LEYADKMFTY | VFVLEMLLKW |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VAYGFKKYFT | NAWCWLDFLI | VDVSLVSLVA | NTLGFAEMGP | IKSLRTLRAL | RPLRALSRFE |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GMRVVVNALV | GAIPSIMNVL | LVCLIFWLIF | SIMGVNLFAG | KFGRCINQTE | GDLPLNYTIV |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| NNKSECESFN | VTGELYWTKV | KVNFDNVGAG | YLALLQVATF | KGWMDIMYAA | VDSRGYEEQP |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| QWEDNLYMYI | YFVVFIIFGS | FFTLNLFIGV | IIDNFNQQKK | KLGGQDIFMT | EEQKKYYNAM |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KKLGSKKPQK | PIPRPLNKYQ | GFIFDIVTKQ | AFDVTIMFLI | CLNMVTMMVE | TDDQSPEKVN |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| ILAKINLLFV | AIFTGECIVK | MAALRHYYFT | NSWNIFDFVV | VILSIVGTVL | SDIIQKYFFS |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| PTLFRVIRLA | RIGRILRLIR | GAKGIRTLLF | ALMMSLPALF | NIGLLLFLVM | FIYSIFGMAN |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| FAYVKWEAGI | DDMFNFQTFA | NSMLCLFQIT | TSAGWDGLLS | PILNTGPPYC | DPNLPNSNGS |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| RGNCGSPAVG | ILFFTTYIII | SFLIVVNMYI | AIILENFSVA | TEESTEPLSE | DDFDMFYEIW |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| EKFDPEATQF | IEYLALSDFA | DALSEPLRIA | KPNQISLINM | DLPMVSGDRI | HCMDILFAFT |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| KRVLGESGEM | DALKIQMEEK | FMAANPSKIS | YEPITTTLRR | KHEEVSATVI | QRAFRRHLLQ |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| RSVKHASFLF | RQQAGSSGLS | DEDAPEREGL | IAYMMNENFS | RRSGPLSSSS | ISSTSFPPSY |
| 1990 | 2000 | 2010 | |||
| DSVTRATSDN | LPVRASDYSR | SEDLADFPPS | PDRDRESIV |