Q6QIY3
PR
Gene name |
Scn10a (Sns) |
Protein name |
Sodium channel protein type 10 subunit alpha |
Names |
Peripheral nerve sodium channel 3, PN3, Sensory neuron sodium channel, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20264 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6QIY3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6QIY3-F1 | Predicted | AlphaFoldDB |
No variants for Q6QIY3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6QIY3 | |||||
No associated diseases with Q6QIY3
6 regional properties for Q6QIY3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ion transport domain | 129 - 405 | IPR005821-1 |
| domain | Ion transport domain | 665 - 893 | IPR005821-2 |
| domain | Ion transport domain | 1152 - 1428 | IPR005821-3 |
| domain | Ion transport domain | 1477 - 1733 | IPR005821-4 |
| domain | Sodium ion transport-associated domain | 903 - 1148 | IPR010526 |
| domain | Voltage-gated sodium channel alpha subunit, inactivation gate | 1420 - 1472 | IPR044564 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| C-fiber | The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. |
| clathrin complex | A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| voltage-gated sodium channel complex | A sodium channel in a cell membrane whose opening is governed by the membrane potential. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| AV node cell action potential | An action potential that occurs in an atrioventricular node cardiac muscle cell. |
| bundle of His cell action potential | An action potential that occurs in a bundle of His cell. |
| cardiac conduction | Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| neuronal action potential | An action potential that occurs in a neuron. |
| regulation of atrial cardiac muscle cell membrane depolarization | Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. |
| regulation of cardiac muscle contraction | Any process that modulates the frequency, rate or extent of cardiac muscle contraction. |
| regulation of heart rate | Any process that modulates the frequency or rate of heart contraction. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| sensory perception of pain | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEFPFGSVGT | TNFRRFTPES | LAEIEKQIAA | HRAAKKGRPK | QRGQKDKSEK | PRPQLDLKAC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQLPRFYGEL | PAELVGEPLE | DLDPFYSTHR | TFIVLDKSRT | ISRFSATWAL | WLFSPFNLIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTAIKVSVHS | WFSIFITVTI | LVNCVCMTRT | DLPEKLEYAF | TVVYTFEALI | KILARGFCLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EFTYLRDPWN | WLDFSVITLA | YVGAAIDLRG | ISGLRTFRVL | RALKTVSVIP | GLKVIVGALI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HSVRKLADVT | ILTVFCLSVF | ALVGLQLFKG | NLKNKCIKNG | TDPHKADNLS | SEMAGDIFIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGTTDPLLCG | NGSDAGHCPN | DYVCRKTSDN | PDFNYTSFDS | FAWAFLSLFR | LMTQDSWERL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQQTLRASGK | MYMVFFVLVI | FLGSFYLVNL | ILAVVTMAYE | EQSQATIAEI | EAKEKKFKEA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEVLQKEQEV | LAALGIDTTS | LYSHNGSPLA | PKNANERRPR | VKSRMSEGST | DDNRSLQSDP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YNQRRMSFLG | LSSGRRRASH | SSVFHFRAPS | QDVSFPDGIL | DDGVFHGDQE | SRRSSILLGR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GAGQAGPLPR | SPLPQSPNPG | PRRGEEGQRG | VPTGELATGA | PEGPALDAAG | QKNFLSADYL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NEPFRAQRAM | SVVSIMTSVI | EELEESKLKC | PPCLISLAQK | YLIWECCPKW | KKFKMVLFEL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VTDPFAELTI | TLCIVVNTVF | MAMEHYPMTD | AFDAMLQAGN | IVFTVFFTME | MAFKIIAFDP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YYYFQKKWNI | FDCVIVTVSL | LELSTSKKGS | LSVLRTFRLL | RVFKLAKSWP | TLNMLIKIIG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NSVGALGNLT | FILAIIVFIF | ALVGKQLLSE | NYGCRRDGIS | VWNGERLRWH | MCDFFHSFLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VFRILCGEWI | ENMWVCMEVS | QDYICLTLFL | TVMVLGNLVV | LNLFIALLLN | SFSADNLTAP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EDDGEVNNLQ | VALARIQVFG | HRASRAITSY | IRSHCRLRWP | KVETQLGMKP | PLTSCKAENH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IATDAVNAAV | GNLAKPALGG | PKENHGDFIT | DPNVWVSVPI | AEGESDLDEL | EEDVEHASQS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SWQEESPKGQ | QELLQQVQKC | EDHQAARSPP | SGMSSEDLAP | YLGERWQREE | SPRVPAEGVD |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DTSSSEGSTV | DCPDPEEILR | KIPELAEELD | EPDDCFPEGC | TRRCPCCKVN | TSKFPWATGW |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| QVRKTCYRIV | EHSWFESFII | FMILLSSGAL | AFEDNYLEEK | PRVKSVLEYT | DRVFTFIFVF |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| EMLLKWVAYG | FKKYFTNAWC | WLDFLIVNIS | LTSLIAKILE | YSDVASIKAL | RTLRALRPLR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ALSRFEGMRV | VVDALVGAIP | SIMNVLLVCL | IFWLIFSIMG | VNLFAGKFSR | CVDTRSNPFS |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| VVNSTFVTNK | SDCYNQNNTG | HFFWVNVKVN | FDNVAMGYLA | LLQVATFKGW | MDIMYAAVDS |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RDINSQPNWE | ESLYMYLYFV | VFIIFGGFFT | LNLFVGVIID | NFNQQKKKLG | GQDIFMTEEQ |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| KKYYNAMKKL | GSKKPQKPIP | RPLNKYQGFV | FDIVTRQAFD | IIIMALICLN | MITMMVETDN |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| QSEEKTKVLG | RINQFFVAVF | TGECVMKMFA | LRQYYFTNGW | NVFDFIVVIL | SISSLLFSAI |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| LSSLESYFSP | TLLRVIRLAR | IGRILRLIRA | AKGIRTLLFA | LMMSLPALFN | IGLLLFLVMF |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| IYSIFGMASF | ANVIDEAGID | DMFNFKTFGN | SMLCLFQITT | SAGWDGLLSP | ILNTGPPYCD |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| PNRPNSNGSK | GNCGSPAVGI | LFFTTYIIIS | FLIVVNMYIA | VILENFNVAT | EESTEPLSED |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| DFDMFYETWE | KFDPEATQFI | AFSALSDFAD | TLSGPLRIPK | PNQNILIQMD | LPLVPGDKIH |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| CLDILFAFTK | NVLGESGELD | SLKTNMEEKF | MATNLSKASY | EPIATTLRCK | QEDISATIIQ |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| KAYRNYMLQR | SLMLSNPLHV | PRAEEDGVSL | PREGYVTFMA | NDNGGLPDKS | ETASATSFPP |
| 1930 | 1940 | 1950 | |||
| SYDSVTRGLS | DRANISTSSS | MQNEDEVTAK | EGKSPGPQ |