Q5QM84
PR
Gene name |
TPC1 (Os01g0678500, LOC_Os01g48680, B1144G04.26-1, OsJ_03004) |
Protein name |
Two pore calcium channel protein 1 |
Names |
OsTPC1, Voltage-dependent calcium channel protein TPC1 |
Species |
Oryza sativa subsp japonica (Rice) |
KEGG Pathway |
osa:4325272 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5QM84
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5QM84-F1 | Predicted | AlphaFoldDB |
No variants for Q5QM84
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5QM84 | |||||
No associated diseases with Q5QM84
4 regional properties for Q5QM84
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 351 - 379 | IPR002048-1 |
| domain | EF-hand domain | 388 - 423 | IPR002048-2 |
| domain | Ion transport domain | 159 - 336 | IPR005821-1 |
| domain | Ion transport domain | 455 - 701 | IPR005821-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| identical protein binding | Binding to an identical protein or proteins. |
| voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| regulation of jasmonic acid biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid. |
| regulation of stomatal movement | Any process that modulates the frequency, rate or extent of stomatal movement. |
| seed germination | The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRERGEMREA | KAPLIAEAAE | HISHSHGSGS | SGTGSHTSGG | GGGWRGSRQY | QRRSDALAYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRYQKAAALV | DLAEDGVGIP | EDVLNDTRFE | RAMRFYFVYL | RLDWLWSLNL | FALILLNFLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPLWCRGYSQ | HACDQRDLYF | LGQLPYLSKT | ESLIYEGLTL | VILVMDIFYP | LSYEGLNLFW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNTINKLKVL | LLFILACDIL | VFAFSPQPFR | VAPYIRVAFL | IMNIRELRMC | AVTLVGMVGT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YLNVLALSLL | FLLFASWLAY | VTFEDTPQGK | TVFSSYGTTL | YQMFILFTTS | NNPDVWVPAY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSSRWSSLFF | IVYVLLGVYF | LTNLILAVIY | DSFKEQLAKQ | VSQADCTRKS | ILEKAFGIID |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATGQGYLNKE | QCLSLLDELN | KYRSLPKTSR | EDFELIFAEL | DQSGDFKVTS | EEFATLCNTI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIKFQKEPPP | SYLEKYPSFY | HSALCEWLKS | FVRSPLFEYI | VIFVLLMNLV | AVIIETTLDI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ENSSSQKVWQ | EVEFVFGWIY | VIEMALKIFS | LGFGAYWMEG | QNKFDFVLTW | TIFIGETLTF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AFPSKLSFLS | NGEWIRYLLL | GRMLRLTRIL | LQVRRFRAFV | ATFFTLMSSL | MPYLGIVFCT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LCIYCSLGLQ | IFGGIVYAGN | PTLEETDLFS | NDYLLFNFND | YPSGMVTLFN | LLVMGNWQAW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MESYRQLTGS | YWSLIYFVSF | YLISVLLLLN | LIVAFVLEAF | FAEMELEKDG | EADIQDPTLE |
| 730 | 740 | 750 | |||
| GRNRRRSVRV | RTKGTMVDIL | LHHMLSNELD | GSQNRDQ |