O88457
PR
Gene name |
Scn11a (Nan, Sns2) |
Protein name |
Sodium channel protein type 11 subunit alpha |
Names |
NaN, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29701 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88457
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88457-F1 | Predicted | AlphaFoldDB |
No variants for O88457
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O88457 | |||||
No associated diseases with O88457
6 regional properties for O88457
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ion transport domain | 128 - 404 | IPR005821-1 |
| domain | Ion transport domain | 573 - 807 | IPR005821-2 |
| domain | Ion transport domain | 1033 - 1297 | IPR005821-3 |
| domain | Ion transport domain | 1346 - 1594 | IPR005821-4 |
| domain | Sodium ion transport-associated domain | 815 - 1029 | IPR010526 |
| domain | Voltage-gated sodium channel alpha subunit, inactivation gate | 1289 - 1341 | IPR044564 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| C-fiber | The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| voltage-gated sodium channel complex | A sodium channel in a cell membrane whose opening is governed by the membrane potential. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| neuronal action potential | An action potential that occurs in a neuron. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| regulation of sensory perception of pain | Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEERYYPVIF | PDERNFRPFT | SDSLAAIEKR | IAIQKERKKS | KDKAAAEPQP | RPQLDLKASR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLPKLYGDIP | PELVAKPLED | LDPFYKDHKT | FMVLNKKRTI | YRFSAKRALF | ILGPFNPLRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LMIRISVHSV | FSMFIICTVI | INCMFMANSM | ERSFDNDIPE | YVFIGIYILE | AVIKILARGF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IVDEFSFLRD | PWNWLDFIVI | GTAIATCFPG | SQVNLSALRT | FRVFRALKAI | SVISGLKVIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GALLRSVKKL | VDVMVLTLFC | LSIFALVGQQ | LFMGILNQKC | IKHNCGPNPA | SNKDCFEKEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSEDFIMCGT | WLGSRPCPNG | STCDKTTLNP | DNNYTKFDNF | GWSFLAMFRV | MTQDSWERLY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RQILRTSGIY | FVFFFVVVIF | LGSFYLLNLT | LAVVTMAYEE | QNRNVAAETE | AKEKMFQEAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLLREEKEAL | VAMGIDRSSL | NSLQASSFSP | KKRKFFGSKT | RKSFFMRGSK | TAQASASDSE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DDASKNPQLL | EQTKRLSQNL | PVDLFDEHVD | PLHRQRALSA | VSILTITMQE | QEKFQEPCFP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CGKNLASKYL | VWDCSPQWLC | IKKVLRTIMT | DPFTELAITI | CIIINTVFLA | VEHHNMDDNL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KTILKIGNWV | FTGIFIAEMC | LKIIALDPYH | YFRHGWNVFD | SIVALLSLAD | VLYNTLSDNN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RSFLASLRVL | RVFKLAKSWP | TLNTLIKIIG | HSVGALGNLT | VVLTIVVFIF | SVVGMRLFGT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KFNKTAYATQ | ERPRRRWHMD | NFYHSFLVVF | RILCGEWIEN | MWGCMQDMDG | SPLCIIVFVL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IMVIGKLVVL | NLFIALLLNS | FSNEEKDGSL | EGETRKTKVQ | LALDRFRRAF | SFMLHALQSF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| CCKKCRRKNS | PKPKETTESF | AGENKDSILP | DARPWKEYDT | DMALYTGQAG | APLAPLAEVE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DDVEYCGEGG | ALPTSQHSAG | VQAGDLPPET | KQLTSPDDQG | VEMEVFSEED | LHLSIQSPRK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KSDAVSMLSE | CSTIDLNDIF | RNLQKTVSPK | KQPDRCFPKG | LSCHFLCHKT | DKRKSPWVLW |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| WNIRKTCYQI | VKHSWFESFI | IFVILLSSGA | LIFEDVNLPS | RPQVEKLLRC | TDNIFTFIFL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LEMILKWVAF | GFRRYFTSAW | CWLDFLIVVV | SVLSLMNLPS | LKSFRTLRAL | RPLRALSQFE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GMKVVVYALI | SAIPAILNVL | LVCLIFWLVF | CILGVNLFSG | KFGRCINGTD | INMYLDFTEV |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PNRSQCNISN | YSWKVPQVNF | DNVGNAYLAL | LQVATYKGWL | EIMNAAVDSR | EKDEQPDFEA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| NLYAYLYFVV | FIIFGSFFTL | NLFIGVIIDN | FNQQQKKLGG | QDIFMTEEQK | KYYNAMKKLG |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| TKKPQKPIPR | PLNKCQAFVF | DLVTSQVFDV | IILGLIVLNM | IIMMAESADQ | PKDVKKTFDI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LNIAFVVIFT | IECLIKVFAL | RQHYFTNGWN | LFDCVVVVLS | IISTLVSRLE | DSDISFPPTL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FRVVRLARIG | RILRLVRAAR | GIRTLLFALM | MSLPSLFNIG | LLLFLVMFIY | AIFGMSWFSK |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| VKKGSGIDDI | FNFETFTGSM | LCLFQITTSA | GWDTLLNPML | EAKEHCNSSS | QDSCQQPQIA |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| VVYFVSYIII | SFLIVVNMYI | AVILENFNTA | TEESEDPLGE | DDFEIFYEVW | EKFDPEASQF |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| IQYSALSDFA | DALPEPLRVA | KPNKFQFLVM | DLPMVMGDRL | HCMDVLFAFT | TRVLGDSSGL |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| DTMKTMMEEK | FMEANPFKKL | YEPIVTTTKR | KEEEQGAAVI | QRAYRKHMEK | MVKLRLKDRS |
| 1750 | 1760 | ||||
| SSSHQVFCNG | DLSSLDVAKV | KVHND |