Q62205
PR
Gene name |
Scn9a |
Protein name |
Sodium channel protein type 9 subunit alpha |
Names |
Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20274 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62205
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62205-F1 | Predicted | AlphaFoldDB |
75 variants for Q62205
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388557861 | 52 | D>E | No | EVA | |
| rs3388548156 | 55 | A>S | No | EVA | |
| rs264947397 | 68 | P>A | No | EVA | |
| rs3391721275 | 68 | P>R | No | EVA | |
| rs264947397 | 68 | P>S | No | EVA | |
| rs3388558944 | 75 | L>M | No | EVA | |
| rs3388558997 | 83 | A>T | No | EVA | |
| rs220266186 | 149 | P>S | No | EVA | |
| rs3388553216 | 168 | L>I | No | EVA | |
| rs3388558938 | 176 | F>L | No | EVA | |
| rs3391721293 | 209 | N>S | No | EVA | |
| rs3391442574 | 240 | Q>E | No | EVA | |
| rs3391714228 | 240 | Q>R | No | EVA | |
| rs3388555689 | 279 | D>Y | No | EVA | |
| rs3388558953 | 378 | Y>* | No | EVA | |
| rs3391442594 | 434 | Q>K | No | EVA | |
| rs239037404 | 522 | R>Q | No | EVA | |
| rs264672698 | 551 | T>A | No | EVA | |
| rs3388555735 | 593 | P>L | No | EVA | |
| rs3388557835 | 594 | R>L | No | EVA | |
| rs3388551722 | 598 | S>N | No | EVA | |
| rs3388557891 | 617 | M>K | No | EVA | |
| rs3388558952 | 649 | I>K | No | EVA | |
| rs3391680958 | 708 | K>I | No | EVA | |
| rs3391647716 | 708 | K>N | No | EVA | |
| rs3388557004 | 728 | Y>C | No | EVA | |
| rs3388558950 | 777 | V>D | No | EVA | |
| rs3388558100 | 832 | V>L | No | EVA | |
| rs3388555580 | 858 | I>F | No | EVA | |
| rs3388550009 | 860 | N>K | No | EVA | |
| rs587521005 | 900 | E>K | No | EVA | |
| rs584030037 | 901 | N>D | No | EVA | |
| rs3388558026 | 929 | E>* | No | EVA | |
| rs3388559817 | 1000 | Y>N | No | EVA | |
| rs3388555063 | 1007 | E>V | No | EVA | |
| rs3388557819 | 1064 | S>N | No | EVA | |
| rs3388559802 | 1067 | K>N | No | EVA | |
| rs3388557886 | 1084 | L>H | No | EVA | |
| rs3388555705 | 1088 | V>L | No | EVA | |
| rs3388551957 | 1102 | T>S | No | EVA | |
| rs3388558053 | 1110 | D>E | No | EVA | |
| rs3388551981 | 1112 | D>E | No | EVA | |
| rs3388558067 | 1137 | E>G | No | EVA | |
| rs3388551984 | 1138 | E>G | No | EVA | |
| rs28035698 | 1170 | S>P | No | EVA | |
| rs28035698 | 1170 | S>T | No | EVA | |
| rs3388551971 | 1187 | V>A | No | EVA | |
| rs3388550094 | 1201 | L>V | No | EVA | |
| rs3388557887 | 1235 | F>V | No | EVA | |
| rs3391646560 | 1271 | L>F* | No | EVA | |
| rs234874101 | 1360 | S>F | No | EVA | |
| rs3388558030 | 1372 | M>K | No | EVA | |
| rs3388558086 | 1390 | V>L | No | EVA | |
| rs264184905 | 1428 | N>S | No | EVA | |
| rs234345401 | 1437 | I>V | No | EVA | |
| rs3388555182 | 1483 | M>I | No | EVA | |
| rs3391646540 | 1524 | C>* | No | EVA | |
| rs3391717909 | 1524 | C>* | No | EVA | |
| rs3391701728 | 1525 | L>HDGDIKSLVCH* | No | EVA | |
| rs3391755441 | 1525 | L>R | No | EVA | |
| rs3388548187 | 1590 | G>A | No | EVA | |
| rs3388558881 | 1638 | S>T | No | EVA | |
| rs3388555849 | 1642 | L>M | No | EVA | |
| rs3388550161 | 1661 | M>V | No | EVA | |
| rs3388551687 | 1670 | E>K | No | EVA | |
| rs3388548229 | 1675 | D>G | No | EVA | |
| rs3388555567 | 1720 | P>L | No | EVA | |
| rs28051092 | 1723 | S>P | No | EVA | |
| rs3388559800 | 1735 | I>V | No | EVA | |
| rs3388551683 | 1742 | I>F | No | EVA | |
| rs3388555721 | 1750 | V>E | No | EVA | |
| rs3388555822 | 1772 | L>Q | No | EVA | |
| rs3388551696 | 1803 | F>S | No | EVA | |
| rs3388559837 | 1855 | D>G | No | EVA | |
| rs3388555766 | 1943 | K>R | No | EVA |
No associated diseases with Q62205
8 regional properties for Q62205
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | IQ motif, EF-hand binding site | 1886 - 1908 | IPR000048 |
| domain | Ion transport domain | 125 - 411 | IPR005821-1 |
| domain | Ion transport domain | 744 - 972 | IPR005821-2 |
| domain | Ion transport domain | 1189 - 1464 | IPR005821-3 |
| domain | Ion transport domain | 1513 - 1768 | IPR005821-4 |
| domain | Sodium ion transport-associated domain | 981 - 1185 | IPR010526 |
| domain | Voltage-gated Na+ ion channel, cytoplasmic domain | 534 - 693 | IPR024583 |
| domain | Voltage-gated sodium channel alpha subunit, inactivation gate | 1456 - 1508 | IPR044564 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| voltage-gated sodium channel complex | A sodium channel in a cell membrane whose opening is governed by the membrane potential. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| sodium channel activity | Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| sodium ion binding | Binding to a sodium ion (Na+). |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| behavioral response to formalin induced pain | Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus. |
| behavioral response to pain | Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| negative regulation of action potential | Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| neuronal action potential | An action potential that occurs in a neuron. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
| sensory perception of pain | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMLPPPGPQ | SFVHFTKQSL | ALIEQRISEE | KAKGHKDEKK | DDEEEGPKPS | SDLEAGKQLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIYGDIPPGM | VSEPLEDLDP | YYADKKTFIV | LNKGKAIFRF | NATPALYMLS | PFSPLRRISI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KILVHSLFSM | LIMCTILTNC | IFMTMSNPPD | WTKNVEYTFT | GIYTFESLIK | ILARGFCVGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FTFLRDPWNW | LDFVVIVFAY | LTEFVNLGNV | SALRTFRVLR | ALKTISVIPG | LKTIVGALIQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVKKLSDVMI | LTVFCLSVFA | LIGLQLFMGN | LKHKCFRKDL | EQNETLESIM | STAESEEELK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYFYYLEGSK | DALLCGFSTD | SGQCPEGYEC | VTAGRNPDYG | YTSFDTFGWA | FLALFRLMTQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DYWENLYQQT | LRAAGKTYMI | FFVVVIFLGS | FYLINLILAV | VAMAYEEQNQ | ANIEEAKQKE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEFQQMLDRL | KKEQEEAEAI | AAAAAEYTSL | GRSRIMGLSE | SSSETSRLSS | KSAKERRNRR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKKKQKLSSG | EEKGDDEKLS | KSGSEESIRK | KSFHLGVEGH | HRAREKRLST | PNQSPLSIRG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLFSARRSSR | TSLFSFKGRG | RDLGSETEFA | DDEHSIFGDN | ESRRGSLFVP | HRPRERRSSN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ISQASRSPPV | LPVNGKMHSA | VDCNGVVSLV | DGPSALMLPN | GQLLPEVIID | KATSDDSGTT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NQMRKKRLSS | SYFLSEDMLN | DPHLRQRAMS | RASILTNTVE | ELEESRQKCP | PWWYRFAHTF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LIWNCSPYWI | KFKKFIYFIV | MDPFVDLAIT | ICIVLNTLFM | AMEHHPMTDE | FKNVLAVGNL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VFTGIFAAEM | VLKLIAMDPY | EYFQVGWNIF | DSLIVTLSLV | ELFLADVEGL | SVLRSFRLLR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VFKLAKSWPT | LNMLIKIIGN | SVGALGNLTL | VLAIIVFIFA | VVGMQLFGKS | YKECVCKINE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NCKLPRWHMN | DFFHSFLIVF | RVLCGEWIET | MWDCMEVAGQ | TMCLIVYMMV | MVIGNLVVLN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LFLALLLSSF | SSDNLTAIEE | DTDANNLQIA | VARIKRGINY | VKQTLREFIL | KSFSKKPKGS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KDTKRTADPN | NKRENYISNR | TLAEISKDHN | FLKEKDKISG | FSSSLDKSFM | DENDYQSFIH |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NPSLTVTVPI | APGESDLENM | NTEELSSDSD | SDYSKERRNR | SSSSECSTVD | NPLPGEEEAE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| AEPINADEPE | ACFTDGCVRR | FPCCQVNIDS | GKGKVWWTIR | KTCYRIVEHS | WFESFIVLMI |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LLSSGALAFE | DIYIEKKKTI | KIILEYADKI | FTYIFILEML | LKWVAYGYKT | YFTNAWCWLD |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| FLIVDVSLVT | LVANTLGYSD | LGPIKSLRTL | RALRPLRALS | RFEGMRVVVN | ALIGAIPSIM |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| NVLLVCLIFW | LIFSIMGVNL | FAGKFYECVN | TTDGSRFSVS | QVANRSECFA | LMNVSGNVRW |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| KNLKVNFDNV | GLGYLSLLQV | ATFKGWMDIM | YAAVDSVNVN | AQPIYEYNLY | MYIYFVIFII |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FGSFFTLNLF | IGVIIDNFNQ | QKKKLGGQDI | FMTEEQKKYY | NAMKKLGSKK | PQKPIPRPGN |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KFQGCIFDLV | TNQAFDITIM | VLICLNMVTM | MVEKEGQTDY | MSFVLYWINV | VFIILFTGEC |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| VLKLISLRHY | YFTVGWNIFD | FVVVILSIVG | MFLAEMIEKY | FVSPTLFRVI | RLARIGRILR |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LIKGAKGIRT | LLFALMMSLP | ALFNIGLLLF | LVMFIYAIFG | MSNFAYVKKE | AGINDMFNFE |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| TFGNSMICLF | QITTSAGWDG | LLAPILNSAP | PDCDPKKVHP | GSSVEGDCGN | PSVGIFYFVS |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| YIIISFLVVV | NMYIAVILEN | FSVATEESTE | PLSEDDFEMF | YEVWEKFDPD | ATQFIEFCKL |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| SDFAAALDPP | LLIAKPNKVQ | LIAMDLPMVS | GDRIHCLDIL | FAFTKRVLGE | SGEMDSLRSQ |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| MEERFMSANP | SKVSYEPITT | TLKRKQEDVS | ATIIQRAYRR | YRLRQNVKNI | SSIYIKDGDR |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| DDDLPNKEDI | VFDNVNENSS | PEKTDATAST | ISPPSYDSVT | KPDQEKYETD | KTEKEDKEKD |
| ESRK |