P91645
PR
Gene name |
MED20 (Tmr, Trfp, CG18780) |
Protein name |
Voltage-dependent calcium channel type A subunit alpha-1 |
Names |
Protein cacophony, Protein nightblind A, Protein no-on-transient B, Dmca1A |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG43368 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P91645
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4Z89 | X-ray | 264 A | a/b/c/d/e/f/g/h/i/j | 1688-1702 | PDB |
| 4Z8A | X-ray | 176 A | B | 1688-1702 | PDB |
| AF-P91645-F1 | Predicted | AlphaFoldDB |
3 variants for P91645
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 284 | L>del | cac-J; lethal at an embryonic stage; loss of synaptic transmission [UniProt] | No | ||
| 989 | E>K | cac-F; lethal at the larval stage 3; loss of synaptic transmission [UniProt] | No | ||
| 1029 | F>I | cac-S; exhibits defects in the patterning of courtship lovesong and a subtle abnormality in visual physiology [UniProt] | No |
No associated diseases with P91645
1 regional properties for P91645
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cationic amino acid transporter, C-terminal | 538 - 588 | IPR029485 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| presynaptic active zone | A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. |
| voltage-gated calcium channel complex | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| high voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. |
| low voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. |
| voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
23 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| autophagosome maturation | Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| calcium ion import across plasma membrane | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| courtship behavior | The behavior of an organism for the purpose of attracting sexual partners. |
| detection of light stimulus involved in visual perception | The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. |
| epithelial fluid transport | The directed movement of fluid across epithelia. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| male courtship behavior, veined wing generated song production | The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song. |
| neuron cellular homeostasis | The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. |
| neuron remodeling | The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. |
| neurotransmitter secretion | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. |
| phototransduction | The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. |
| positive regulation of calcium ion transport into cytosol | Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. |
| positive regulation of synaptic assembly at neuromuscular junction | Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction. |
| regulation of heart rate | Any process that modulates the frequency or rate of heart contraction. |
| regulation of membrane potential in photoreceptor cell | Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. |
| regulation of neurotransmitter secretion | Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. |
| visual behavior | The behavior of an organism in response to a visual stimulus. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGPKKEENP | PGGGPTSLFI | LTEDNPIRKY | TRFIIEWPPF | EYAVLLTIIA | NCVVLALEEH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPGGDKTVLA | QKLEKTEAYF | LCIFCVEASL | KILALGLVLH | KHSYLRNIWN | IMDFFVVVTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FMTQYPQIGP | EVDLRTLRAI | RVLRPLKLVS | GIPSLQVVLK | SIIKAMAPLL | QIGLLVLFAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIFAIIGLEF | YSGALHKTCY | SLEDPNKLVK | EGESETPCNT | DNILEKATGS | FVCNNTTSMC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEKWEGPNSG | ITSFDNIGFA | MLTVFQCITM | EGWTAILYWT | NDALGSAFNW | IYFVPLIVIG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SFFMLNLVLG | VLSGEFSNER | NRVERRMEFQ | KCRFRAMFQT | AMVSYLDWIT | QAEEVILAEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTTEEEKMHI | MEARRRNAAK | RKKLKSLGKS | KSTDTEEEEA | EEDYGDDGYL | KTRSKPQGSC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGFWRAEKRF | RFWIRHTVKT | QWFYWFVIVL | VFLNTVCVAV | EHYGQPSFLT | EFLYYAEFIF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGLFMSEMFI | KMYALGPRIY | FESSFNRFDC | VVISGSIFEV | IWSEVKGGSF | GLSVLRALRL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LRIFKVTKYW | SSLRNLVISL | LNSMRSIISL | LFLLFLFILI | FALLGMQLFG | GQFNLPGGTP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ETNFNTFPIA | LLTVFQILTG | EDWNEVMYQG | IISQGGAQKG | MIYSIYFIVL | VLFGNYTLLN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VFLAIAVDNL | ANAQELTAAE | EEQVEEDKEK | QLQELEKEME | ALQADGVHVE | NGDGAVAPSK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SKGKKKEEEK | KEEEEVTEGP | KPMLPYSSMF | ILSPTNPIRR | GAHWVVNLPY | FDFFIMVVIS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MSSIALAAED | PVRENSRRNK | ILNYFDYAFT | GVFTIEMLLK | IVDLGVILHP | GSYLREFWNI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MDAVVVICAA | VSFGFDMSGS | SAGQNLSTIK | SLRVLRVLRP | LKTIKRVPKL | KAVFDCVVNS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LKNVVNILIV | YILFQFIFSV | IGVQLFNGKF | FYCTDESKHT | SAECQGSYFK | YEEDELLPKQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ELRVWKPRAF | HYDNVAAAML | TLFAVQTGEG | WPQVLQHSMA | ATYEDRGPIQ | NFRIEMSIFY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IVYFIVFPFF | FVNIFVALII | ITFQEQGEAE | LQDGEIDKNQ | KSCIDFTIGA | RPLERYMPKN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RNTFKYKVWR | IVVSTPFEYF | IMMLIVFNTL | LLMMKYHNQG | DMYEKSLKYI | NMGFTGMFSV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| ETVLKIIGFG | VKNFFKDPWN | IFDLITVLGS | IVDALWMEFG | HDDSNSINVG | FLRLFRAARL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| IKLLRQGYTI | RILLWTFVQS | FKALPYVCLL | IAMLFFIYAI | IGMQVFGNIK | LGTVENSITR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| HNNFQSFIQG | VMLLFRCATG | EAWPNIMLAC | LKGKACDDDA | EKAPGEYCGS | TLAYAYFVSF |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| IFFCSFLMLN | LFVAVIMDNF | DYLTRDSSIL | GAHHLDEFVR | IWAEYDPNAT | GKIHYTEMYD |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| MLKNMDPPLG | FGNKCPNRLA | YKKLIRMNMP | LDDELRVQFT | TTLFALIREN | LSIKMRAPEE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| MDQADMELRE | TITNIWPLQA | KKMLNLLVPP | SDQLNKGKLS | VGKIYAGFLI | LESWRSTRFG |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| QLDSGMPMLE | LQDASRHPSQ | ESLTGADAGH | LHPGHSYMNG | HRRSPSLRHN | GSPLARSPSP |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| RRRGHQYIHH | DIGFSDTVSN | VVEMVKETRH | PRHGNSHPRY | PRGSWSASTS | PARSPSPSRY |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| GGHLSRSKRT | QLPYPTYGTT | SLCQRSRSPS | PARLQEMRER | DRLGYGIDMG | VTHVQHSYPT |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| LASRRAGIGR | RLPPTPSKPS | TLQLKPTNIN | FPKLNASPTH | THHSTPHSVH | SLPHHRDLLR |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| DPRDMYYSSR | ERERDRERLR | DRDRDRDRDR | LHEYDLRYEY | RDRERELYER | ERDREREVER |
| 1810 | 1820 | 1830 | 1840 | 1850 | |
| ERLEYIAPLS | FEQALAMGRT | GRVLPSPVLN | GFKPKSGLNP | RHSDSDEEDW | C |