Q94KI8
PR
Gene name |
TPC1 (CCH1, FOU2, At4g03560, F9H3.19, T5L23.5) |
Protein name |
Two pore calcium channel protein 1 |
Names |
Calcium channel protein 1, AtCCH1, Fatty acid oxygenation up-regulated protein 2, Voltage-dependent calcium channel protein TPC1, AtTPC1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G03560 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
16 structures for Q94KI8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5DQQ | X-ray | 287 A | A | 12-733 | PDB |
| 5E1J | X-ray | 331 A | A | 1-733 | PDB |
| 5TUA | X-ray | 330 A | A | 1-733 | PDB |
| 6CX0 | X-ray | 350 A | A | 11-733 | PDB |
| 6E1K | EM | 330 A | A/B | 11-733 | PDB |
| 6E1M | EM | 330 A | A/B | 11-733 | PDB |
| 6E1P | EM | 370 A | A/B | 11-733 | PDB |
| 7FHK | EM | 330 A | A/C | 1-733 | PDB |
| 7FHL | EM | 310 A | A/C | 1-733 | PDB |
| 7FHN | EM | 330 A | A/C | 1-733 | PDB |
| 7FHO | EM | 280 A | A/C | 1-733 | PDB |
| 7TBG | EM | 250 A | A/B | 1-733 | PDB |
| 7TDD | EM | 350 A | A/B | 16-690 | PDB |
| 7TDE | EM | 320 A | A/B | 1-733 | PDB |
| 7TDF | EM | 270 A | A/B | 1-733 | PDB |
| AF-Q94KI8-F1 | Predicted | AlphaFoldDB |
21 variants for Q94KI8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_1580283_C_T | 11 | L>F | No | 1000Genomes | |
| tmp_4_1580286_G_A | 12 | G>S | No | 1000Genomes | |
| ENSVATH06435449 | 14 | G>A | No | 1000Genomes | |
| ENSVATH06435453 | 63 | Y>S | No | 1000Genomes | |
| ENSVATH00458414 | 116 | T>N | No | 1000Genomes | |
| tmp_4_1581579_G_T | 160 | V>L | No | 1000Genomes | |
| tmp_4_1582136_C_T | 249 | T>I | No | 1000Genomes | |
| ENSVATH00458428 | 318 | G>E | No | 1000Genomes | |
| tmp_4_1582754_A_C | 338 | K>T | No | 1000Genomes | |
| ENSVATH06435470 | 371 | I>R | No | 1000Genomes | |
| tmp_4_1583181_C_G | 392 | C>W | No | 1000Genomes | |
| ENSVATH10575706 | 393 | Q>H | No | 1000Genomes | |
| ENSVATH06435478 | 405 | P>L | No | 1000Genomes | |
| ENSVATH00458432 | 410 | H>N | No | 1000Genomes | |
| tmp_4_1583389_A_G | 431 | N>S | No | 1000Genomes | |
| ENSVATH10575709 | 503 | V>I | No | 1000Genomes | |
| tmp_4_1584623_G_A | 594 | G>E | No | 1000Genomes | |
| tmp_4_1584651_G_T | 603 | L>F | No | 1000Genomes | |
| ENSVATH00458442 | 634 | V>A | No | 1000Genomes | |
| tmp_4_1585113_A_T | 648 | S>C | No | 1000Genomes | |
| tmp_4_1585340_A_T | 686 | K>I | No | 1000Genomes |
No associated diseases with Q94KI8
No regional properties for Q94KI8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q94KI8 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| identical protein binding | Binding to an identical protein or proteins. |
| voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| regulation of jasmonic acid biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid. |
| regulation of stomatal movement | Any process that modulates the frequency, rate or extent of stomatal movement. |
| seed germination | The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDPLIGRDS | LGGGGTDRVR | RSEAITHGTP | FQKAAALVDL | AEDGIGLPVE | ILDQSSFGES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARYYFIFTRL | DLIWSLNYFA | LLFLNFFEQP | LWCEKNPKPS | CKDRDYYYLG | ELPYLTNAES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IIYEVITLAI | LLVHTFFPIS | YEGSRIFWTS | RLNLVKVACV | VILFVDVLVD | FLYLSPLAFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLPFRIAPYV | RVIIFILSIR | ELRDTLVLLS | GMLGTYLNIL | ALWMLFLLFA | SWIAFVMFED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQQGLTVFTS | YGATLYQMFI | LFTTSNNPDV | WIPAYKSSRW | SSVFFVLYVL | IGVYFVTNLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAVVYDSFKE | QLAKQVSGMD | QMKRRMLEKA | FGLIDSDKNG | EIDKNQCIKL | FEQLTNYRTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PKISKEEFGL | IFDELDDTRD | FKINKDEFAD | LCQAIALRFQ | KEEVPSLFEH | FPQIYHSALS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QQLRAFVRSP | NFGYAISFIL | IINFIAVVVE | TTLDIEESSA | QKPWQVAEFV | FGWIYVLEMA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKIYTYGFEN | YWREGANRFD | FLVTWVIVIG | ETATFITPDE | NTFFSNGEWI | RYLLLARMLR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LIRLLMNVQR | YRAFIATFIT | LIPSLMPYLG | TIFCVLCIYC | SIGVQVFGGL | VNAGNKKLFE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TELAEDDYLL | FNFNDYPNGM | VTLFNLLVMG | NWQVWMESYK | DLTGTWWSIT | YFVSFYVITI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLLLNLVVAF | VLEAFFTELD | LEEEEKCQGQ | DSQEKRNRRR | SAGSKSRSQR | VDTLLHHMLG |
| 730 | |||||
| DELSKPECST | SDT |